Results 111 to 120 of about 21,456 (303)

Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?

Cellular Physiology and Biochemistry, 2018
Kisspeptin is involved in the control of human reproduction bridging the gap between the sex steroid levels and feedback mechanisms that control the gonadotropin releasing hormone (GnRH) secretion; however, studies considering this peptide and ...
Camila M. Trevisan, Erik Montagna, Renato de Oliveira, Denise M. Christofolini, Caio P. Barbosa, Keith A. Crandall, Bianca  Bianco   +6 more
doaj   +1 more source

Positive correlation of oestradiol level on trigger day with the secretion level of endometrial kisspeptin and leukaemia Inhibitory Factor in the Mid-Luteal Stimulated Cycle

Journal of Human Reproductive Sciences, 2022
Background: Kisspeptin plays a role in the oestradiol negative-feedback regulation of GnRH as well as gonadotropin. In addition, kisspeptin has been postulated to induce the production of an important cytokine called leukaemia inhibitory factor (LIF ...
Arie Adrianus Polim, Nusratuddin Abdullah, Mochammad Hatta, Rosdiana Natzir, Soegiharto Soebijanto, Caroline Hutomo, Aryando Pradana, Reino Rambei   +7 more
doaj   +1 more source

The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent. [PDF]

, 2011
BACKGROUND: Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin do not progress through puberty, caused by a failure to release GnRH.
Allard, Pat, Aparicio, Samuel AJ, Burleigh, Angela, Colledge, William H, d'Anglemont de Tassigny, Xavier, Fee, John, Huntsman, David G, McKinney, Steven, Poon, Steven, Prentice, Leah M, Ruiz de Algara, Teresa, Sutcliffe, Margaret, Turashvili, Gulisa, Yap, Damian   +13 more
core   +2 more sources

Hyperactive LH pulses and elevated kisspeptin and NKB gene expression in the arcuate nucleus of a PCOS mouse model.

Endocrinology, 2020
Polycystic ovary syndrome (PCOS), a common reproductive disorder in women, is characterized by hyperandrogenemia, chronic anovulation, cystic ovarian follicles, and LH hyper-pulsatility, but the pathophysiology is incompletely understood.
L. Esparza, Danielle Schafer, Bryan S. Ho, V. Thackray, A. Kauffman   +4 more
semanticscholar   +1 more source

Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep

Biology, 2021
Simple Summary Mistiming of puberty onset has negative consequences for humans and livestock. Puberty depends on increased brain secretion of gonadotrophin-releasing hormone (GnRH), which causes pituitary luteinizing hormone (LH) release.
Eliana G Aerts, K. Harlow, Max J Griesgraber, E. Bowdridge, S. Hardy, Casey C Nestor, S. Hileman   +6 more
semanticscholar   +1 more source

The gatekeepers of growth: The neural roles and regulation of growth hormone‐releasing hormone neurons

Journal of Neuroendocrinology, EarlyView.
Abstract The neuroendocrine control of growth is mediated by the hypothalamic–pituitary–somatic (HPS) axis. This involves the hypothalamic release of growth hormone‐releasing hormone (GHRH), which stimulates the pituitary secretion of growth hormone (GH).
Bradley B. Jamieson
wiley   +1 more source

Kisspeptin and Clinical Disorders [PDF]

, 2013
The hypothalamic hormone GnRH has traditionally been viewed as a central driver of the hypothalamic-pituitary-gonadal axis. Pulsatile GnRH release is required for pulsatile gonadotropin secretion, which then modulates gonadal steroid feedback and brings about full fertility in the adult.
Letícia Gontijo, Silveira, Ana Claudia, Latronico, Stephanie Beth, Seminara   +2 more
openaire   +2 more sources

Kisspeptin Activates Ankrd 26 Gene Expression in Migrating Embryonic GnRH Neurons

Frontiers in Endocrinology, 2016
Kisspeptin, a newly discovered neuropeptide regulates gonadotropin-releasing hormone (GnRH). Kisspeptins are a large RF-amide family of peptides. The kisspeptin coded by kiss1 gene is a 145-amino acid- protein that is cleaved to C-terminal peptide ...
Tomoko eSoga, Lim Wei Ling, Alan Soo-Beng Khoo, Ishwar S Parhar   +3 more
doaj   +1 more source

Xenoestrogens Ethinyl Estradiol and Zearalenone Cause Precocious Puberty in Female Rats via Central Kisspeptin Signaling [PDF]

, 2015
Xenoestrogens from synthetic or natural origin represent an increasing risk of disrupted endocrine functions including the physiological activity of the hypothalamo-pituitary-gonad axis.
Csilla Molnár, Dániel Kuti, Erik Hrabovszky, Imre Kalló, Krisztina J. Kovács, Rókus Kriszt, Szilamér Ferenczi, Zsuzsanna Szőke, Zsuzsanna Winkler, Ágnes Polyák   +9 more
core   +1 more source

Reproductive Deficits Induced by Prenatal Anti-Mullerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells.

Endocrinology, 2021
Polycystic ovary syndrome (PCOS) is a common reproductive disorder characterized by elevated androgens and anti-Mullerian hormone (AMH). These hormones remain elevated throughout pregnancy, and potential effects of hormone exposure on offspring from ...
Emily V. Ho, Chengxian Shi, Jessica Cassin, Michelle Y He, Ryan D Nguyen, Genevieve E. Ryan, Karen J. Tonsfeldt, P. Mellon   +7 more
semanticscholar   +1 more source