Results 111 to 120 of about 16,602 (265)

Brain‐Derived Neurotrophic Factor (BDNF) and Sex Differences in Metabolic Regulation

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Brain‐derived neurotrophic factor (BDNF) is expressed in the hypothalamus of both female and male mice (left‐hand side of the panel); however, it exerts distinct functions in either sex, explaining some sexually dimorphic phenotypes in mice and humans (right‐hand side of the panel).
Ariane M. Zanesco, Licio A. Velloso
wiley   +1 more source

Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction

eLife, 2019
The brain regulates fertility through gonadotropin-releasing hormone (GnRH) neurons. Estradiol induces negative feedback on pulsatile GnRH/luteinizing hormone (LH) release and positive feedback generating preovulatory GnRH/LH surges.
Luhong Wang, Charlotte Vanacker, Laura L Burger, Tammy Barnes, Yatrik M Shah, Martin G Myers, Suzanne M Moenter   +6 more
doaj   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, Volume 3, Issue 3, September 2025.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice [PDF]

, 2018
Restraint stress is a psychosocial stressor that suppresses reproductive status, including LH pulsatile secretion, but the neuroendocrine mechanisms underlying this inhibition remains unclear.
Hughes, Jessica K, Kauffman, Alexander S, Parra, Ruby A, Volk, Katrina M, Yang, Jennifer A   +4 more
core   +1 more source

Physiologically Based Pharmacokinetic (PBPK) Model to Predict the Magnitude of Drug–Drug Interaction Between Fezolinetant and CYP1A2 Inhibitors

The Journal of Clinical Pharmacology, Volume 65, Issue 9, Page 1096-1105, September 2025.
Abstract Fezolinetant is a non‐hormonal, selective neurokinin 3 receptor antagonist approved in multiple countries including the United States, in Europe, and in Asia for the treatment of moderate to severe vasomotor symptoms in menopausal women. Fezolinetant is primarily metabolized by CYP1A2 and was found to be a sensitive substrate for CYP1A2 ...
Mary P. Choules, Yukio Otsuka, Jace C. Nielsen, Megumi Iwai, Peter L. Bonate   +4 more
wiley   +1 more source

Unravelling the evolutionary history of kisspeptin

eLife, 2020
Experiments in sea cucumbers reveal how the physiological responses regulated by a neuropeptide called kisspeptin have evolved.
Maria I Arnone, Paola Oliveri
openaire   +5 more sources

MicroRNA (miRNA) in Plasma Small Extracellular Vesicles (sEV) as Potential Early Indicators of Dairy Cow Subfertility

Journal of Extracellular Biology, Volume 4, Issue 9, September 2025.
ABSTRACT Pregnancy and live birth rates are commonly used metrics to define fertility in humans and animals. The impact of aberrant microRNA (miRNA) expression on fertility‐related genes represents a significant knowledge gap in understanding post‐transcriptional regulatory mechanisms associated with reproductive dysfunction.
Pevindu Abeysinghe, Natalie Turner, Holly Flay, Susanne Meier, Leila Cuttle, Murray D. Mitchell   +5 more
wiley   +1 more source

Design and synthesis of fluorescent probes for GPR54. [PDF]

, 2014
Kisspeptins are neuropeptides that induce the secretion of gonadotropin-releasing hormone via the activation of the cognate receptor, G-protein coupled receptor 54 (GPR54).
Fujii, Nobutaka, Hirasawa, Akira, Ieda, Nahoko, Kaneda, Masato, Maeda, Kei-ichiro, Misu, Ryosuke, Ohno, Hiroaki, Oishi, Shinya, Tsukamura, Hiroko, Uenoyama, Yoshihisa   +9 more
core   +1 more source

Dynamic changes in Ccn3 expression across the limbic forebrain through the mouse estrous cycle and during lactation

Journal of Neuroendocrinology, Volume 37, Issue 9, September 2025.
Abstract Background. Cellular communication network factor 3 (CCN3), also known as nephroblastoma overexpressed (NOV), is an adipocytokine that has recently been suggested to be secreted selectively by hypothalamic arcuate nucleus kisspeptin (ARNKISS) neurons to protect bone density during lactation. Methods.
Shel‐Hwa Yeo, Zulfiye Gul, Ziyue Zhou, Leila Muresan, Ellen G. Wall, Allan E. Herbison   +5 more
wiley   +1 more source

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain [PDF]

, 2018
The mammalian brain undergoes sexual differentiation by gonadal hormones during the perinatal critical period. However, the machinery at earlier stages has not been well studied.
Fujiyama Tomoyuki, Funato Hiromasa, Hoshino Mikio, Ishikawa Yukiko, Kakizaki Miyo, Kanemaru Kazumasa, Kanno Satomi, Kawaguchi Yoshiya, Magnuson Mark A., Miyashita Satoshi, Muratani Masafumi, Nabeshima Yo-ichi, Nagaoka Mai, Owa Tomoo, Shibuya Akira, Tsuneoka Yousuke, Yamashita Mariko, Yanagawa Yuchio, Yanagisawa Masashi, 村谷 匡史, 金丸 和正   +20 more
core   +2 more sources