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Seminars in Reproductive Medicine, 2019
AbstractThe relationship between elevated prolactin and infertility has been known for a long time, but the specific mechanism by which prolactin inhibited reproduction had been uncertain. The discovery of kisspeptin has provided novel insights into how prolactin might cause infertility, with extensive evidence that elevated prolactin inhibits ...
David R, Grattan, Raphael E, Szawka
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AbstractThe relationship between elevated prolactin and infertility has been known for a long time, but the specific mechanism by which prolactin inhibited reproduction had been uncertain. The discovery of kisspeptin has provided novel insights into how prolactin might cause infertility, with extensive evidence that elevated prolactin inhibits ...
David R, Grattan, Raphael E, Szawka
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Immunocytochemical localization of kisspeptin and kisspeptin receptor in the primate testis
Journal of Medical Primatology, 2016AbstractBackgroundHypothalamic kisspeptin–kisspeptin receptor signalling in primates ensures the successful progression into puberty during development and maintenance of reproductive capacity during adulthood. Human testis has been shown to express high‐to‐moderate levels of kisspeptin and kisspeptin receptor gene expression.
Joachim Wistuba +2 more
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Distribution of Kisspeptin Neurones in the Adult Female Mouse Brain
Journal of Neuroendocrinology, 2009 International audienceKisspeptin-GPR54 signalling is essential for normal reproductive functioning. However, the distribution of kisspeptin neuronal cell bodies and their projections is not well established.
Jenny Clarkson +2 more
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British Journal of Clinical Pharmacology, 2010 Aims: To investigate (i) if kisspeptin administration alters heart rate (HR) or blood pressure (BP) in healthy male and female volunteers, (ii) whether circulating plasma kisspeptin concentrations in healthy pregnant women and women with hypertensive ...
Waljit S Dhillo +2 more
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2010
In recent years, a substantial body of evidence has accumulated suggesting that the hypothalamic peptide hormone kisspeptin and its cognate receptor, G-protein-coupled receptor 54, play a fundamental role both as gatekeepers for the initiation of puberty and in the regulation of the hypothalamic-pituitary-gonadal axis.
Saira, Hameed, Waljit S, Dhillo
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In recent years, a substantial body of evidence has accumulated suggesting that the hypothalamic peptide hormone kisspeptin and its cognate receptor, G-protein-coupled receptor 54, play a fundamental role both as gatekeepers for the initiation of puberty and in the regulation of the hypothalamic-pituitary-gonadal axis.
Saira, Hameed, Waljit S, Dhillo
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Seminars in Reproductive Medicine, 2007
Although the functions of kisspeptin originally were believed to be restricted to metastasis suppression, a novel role for this protein was discovered in 2003. Loss-of-function mutations in its receptor, GPR54, were found to cause absence of puberty and hypogonadotropic hypogonadism in humans.
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Although the functions of kisspeptin originally were believed to be restricted to metastasis suppression, a novel role for this protein was discovered in 2003. Loss-of-function mutations in its receptor, GPR54, were found to cause absence of puberty and hypogonadotropic hypogonadism in humans.
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Kisspeptin as a Behavioral Hormone
Seminars in Reproductive Medicine, 2019AbstractSuccessful reproduction is dependent not only on hormonal endocrine responses but also on suitable partner selection, copulatory acts, as well as associated emotional, behavioral, and cognitive processes many of which are supported by the limbic system.
Mills, EGA, O'Byrne, KT, Comninos, AN
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Kisspeptin and Seasonality of Reproduction
2013Wild and domesticated species display seasonality in reproductive function, controlled predominantly by photoperiod. Seasonal alterations in breeding status are caused by changes in the secretion of gonadotropin-releasing hormone (GnRH) that are mediated by upstream neuronal afferents that regulate the GnRH cells.
Clarke, Iain J, Caraty, Alain
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Kisspeptin and Gynecological Cancer
Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering, 2020Background: Kisspeptin was identified in 1996 and it was known as a suppressor of metastatic malignant tumors. Kisspeptin and its receptor KISS1R have been identified as potential prognostic or therapeutic markers in cancers. Recent study suggested that kisspeptin plays an important role in gynecological cancer, including breast cancer, ovarian cancer,
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2008
The G-protein coupled receptor GPR54 has an essential role in the initiation and maintenance of mammalian fertility. Humans and mice with mutations in GPR54 have hypogonadotropic hypogonadism characterized by absence of sexual maturation and low levels of gonadotropic hormones (LH and FSH).
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The G-protein coupled receptor GPR54 has an essential role in the initiation and maintenance of mammalian fertility. Humans and mice with mutations in GPR54 have hypogonadotropic hypogonadism characterized by absence of sexual maturation and low levels of gonadotropic hormones (LH and FSH).
openaire +2 more sources