Results 81 to 90 of about 2,344,694 (261)
Frontiers in Bioengineering and Biotechnology, 2016 Computational models of cardiac electrophysiology provided insights into arrhythmogenesis and paved the way towards tailored therapies in the last years.
Axel eLoewe +8 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Laboratory Animal Research, 2016 Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pathology parameters in cynomolgus monkeys, and ...
Hyun-Kyu Park +10 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
INCATools/ontology-access-kit: v0.2.4
, 2023 What's Changed xaf parsing enhancements by @cmungall in https://github.com/INCATools/ontology-access-kit/pull/473 add a subset of OAK logos to this repo by @nlharris in https://github.com/INCATools/ontology-access-kit/pull/478 delete from main folder ...
Sierra Moxon +18 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
, 2021 The Phoenix Outrigger Kits provides dynamic MCP extension with active flexion allowing complete available range of motion. The slotted pulleys can be aligned for a 90 degree angle of pull.
core
INCATools/ontology-access-kit: v0.1.62
, 2022 What's Changed Updating docs for building sqlite by @cmungall in https://github.com/INCATools/ontology-access-kit/pull/401 FHIR updates by @joeflack4 in https://github.com/INCATools/ontology-access-kit/pull/374 Docstring fix for diff-via-mappings by ...
Sierra Moxon +16 more
core +1 more source
Advances in Oceanography and Limnology, 2016 The increasing number of reservoirs around the world today reaches a surface area of around 500,000 km², equaling one third of that of non-artificial surface water bodies.
Stephan Hilgert +3 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source