Results 251 to 260 of about 18,442 (279)

Neutrophil KLF2 regulates inflammasome-dependent neonatal mortality from endotoxemia

Journal of Leukocyte Biology
Preterm neonates die at a significantly higher rate from sepsis than full-term neonates, attributable to their dysregulated immune response. In addition to tissue destruction caused directly by bacterial invasion, an overwhelming cytokine response by the
Devashis Mukherjee, Sriram Satyavolu, Asha Thomas, Sarah Cioffi, Yuexin Li, E. R. Chan, Katherine Wen, Alex Y. Huang, Mukesh K. Jain, George R. Dubyak, Lalitha Nayak   +10 more
semanticscholar   +5 more sources

Regulation of KLF2 in the Thymus

The FASEB Journal, 2008
Our laboratory has identified the transcription factor Krüppel‐like factor 2 (KLF2) as an important regulator of T cell migration. KLF2 deficient T cells mature normally but are retained in thymus. KLF2 controls the expression of receptors such as S1P 1 and CD62L in T cells. The regulation of
Michael Alexander Weinreich, Stephen C. Jameson, Kristin A. Hogquist   +2 more
openaire   +1 more source

KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection.

Science
Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress differentiation toward alternative fates remains ...
Eric Fagerberg, John Attanasio, Christine Dien, Jaiveer Singh, Emily A Kessler, Leena Abdullah, Jian Shen, Brian G Hunt, Kelli A. Connolly, Edward De Brouwer, Jiaming He, Nivedita R Iyer, Jessica Buck, Emily R Borr, M. Damo, Gena G. Foster, Josephine R. Giles, Yina H. Huang, J. Tsang, Smita Krishnaswamy, Weiguo Cui, Nikhil S. Joshi   +21 more
semanticscholar   +1 more source

Curcumin Regulates Microglia Polarization to Alleviate Ischemic Stroke by Targeting microRNA‐205‐5p/Kruppel‐Like Factor 2 (KLF2)/Activating Transcription Factor 2 (ATF2) Axis

Chemical Biology and Drug Design
Ischemic stroke (IS) often causes fearful sequela, even death. Curcumin was beneficial to IS, but its underlying molecular mechanism is unclear. Mice were subjected to middle cerebral artery occlusion (MCAO) surgery, and BV‐2 cells were treated with ...
Xiangyu Cao, Yingzi Pu
semanticscholar   +1 more source

KLF2 expression in IgG plasma cells at their induction site regulates the migration program.

Journal of Experimental Medicine
Newly generated plasma cells in secondary lymphoid organs migrate to niches in the bone marrow, wherein they survive as long-lived plasma cells (LLPCs).
W. Ise, Takuya Koike, Nozomi Shimada, Hiromi Yamamoto, Yuki Tai, Taiichiro Shirai, Ryoji Kawakami, Mana Kuwabara, Chie Kawai, Kyoko Shida, Takeshi Inoue, Nozomi Hojo, Kenji Ichiyama, S. Sakaguchi, Katsuyuki Shiroguchi, Kazuhiro Suzuki, Tomohiro Kurosaki   +16 more
semanticscholar   +1 more source

Role of KLF2: New insight in inflammatory acne pathogenesis

Journal of Cosmetic Dermatology, 2020
AbstractBackgroundAcne is an inflammatory skin condition of pilosebaceous unit. Its pathogenesis is multifactorial with a central role of inflammatory and pro‐inflammatory cytokines mediators. Downregulated Kruppel‐like factor 2 (KLF2) leads to rapid secretion of many cytokines that are involved in acne pathogenesis.AimsThis study aimed at evaluating ...
Menha A. Ibrahim, Shuzan Ali Mohammed, Doaa M. Elhabak   +2 more
openaire   +2 more sources

Chronic NK cell activation results in a dysfunctional, tissue resident-like state mediated by KLF2 deficiency.

Blood
Adoptive transfer of NK cells can induce complete remissions in 30-50% of patients with refractory acute myeloid leukemia and lymphoma. While blood chimerism occurs, attaining functional homing to the site of tumor without exhaustion has been elusive ...
Jacob A Myers, Rih-Sheng Huang, S. Phung, Jeremey M. Chacón, L. Bendzick, A. Weis, Mihir Shetty, Taylor A. DePauw, M. Khaw, Juan E Abrahante Llorens, Stephen D. O’Flanagan, K. M. Ashby, John R Lozada, Stephen C. Jameson, Justin H. Hwang, Frank Cichocki, M. Felices, Jeffrey S Miller   +17 more
semanticscholar   +1 more source

Puerarin Inhibits the Development of Thyroid Cancer Through KLF2/NOTCH1 Signaling.

Discover medicine
BACKGROUND Puerarin is the major bioactive ingredient extracted from Pueraria lobata. Puerarin has an antitumor effect on many kinds of cancer. Accordingly, the aim of this study was to investigate the effect and mechanism of puerarin on thyroid cancer ...
Yanghong Zhou, Wei Li, Hong Huang
semanticscholar   +1 more source

HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells

Circulation, 2023
BACKGROUND: Atherosclerosis preferentially occurs in arterial regions of disturbed blood flow, and stable flow (s-flow) protects against atherosclerosis by incompletely understood mechanisms.
Ian A. Tamargo, K. Baek, Chenbo Xu, D. Kang, Yerin Kim, Aitor Andueza, Darian Williams, Catherine J. Demos, Nicolas Villa-Roel, Sandeep Kumar, Christian Park, Rachel Choi, Janie Johnson, Seowon Chang, Paul Kim, Sheryl Tan, Kiyoung Jeong, Shoutaro Tsuji, Hanjoong Jo   +18 more
semanticscholar   +1 more source