Results 141 to 150 of about 33,787 (326)
Skeletal muscle as a regulator of the longevity protein, Klotho [PDF]
, 2014 Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been ascribed to exercise and physical activity.
Ambrosio, F +8 more
core +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.Dietary protein restriction protects the aging heart in the context of obesity by limiting mitochondrial DNA leakage and suppressing cGAS–STING‐driven inflammation. Through AMPK–ULK1‐dependent mitophagy, protein restriction restores mitochondrial quality control, reduces cardiac remodeling, and preserves metabolic homeostasis during obesity‐associated ...
Wagner S. Dantas +8 more
wiley +1 more source
Soluble alpha-Klotho as a Novel Biomarker in the Early Stage of Nephropathy in Patients with Type 2 Diabetes [PDF]
, 2014 OBJECTIVE: Although α-klotho is known as an anti-aging, antioxidant, and cardio-renal protective protein, the clinical implications of soluble α-klotho levels in patients with diabetes have not been evaluated.
김상수
core
Long non-coding RNA MEG3 regulates the progress of osteoarthritis by regulating the miR-34a/Klotho axis [PDF]
, 2022 Gaoxin Xiong +6 more
openalex +1 more source
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, Volume 600, Issue 2, Page 140-163, January 2026.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
Effects of etelcalcetide on fibroblast growth factor 23 in patients with secondary hyperparathyroidism receiving hemodialysis [PDF]
, 2019 Background: Etelcalcetide is an intravenous calcimimetic approved for treatment of secondary hyperparathyroidism (sHPT) in patients receiving hemodialysis. Besides lowering parathyroid hormone (PTH), etelcalcetide also significantly reduces fibroblast
Block, Geoffrey A. +9 more
core +1 more source
The Protective Role of Klotho in CKD-Associated Cardiovascular Disease
Kidney Diseases, 2020 Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in advanced CKD. The major pathological changes of CKD-associated CVD are severe vascular media calcification, aberrant cardiac remodeling such as hypertrophy and
Xianjin Bi +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu +20 more
wiley +1 more source
Longevity Genes: From Primitive Organisms to Humans [PDF]
, 2002 A variety of lines of evidence indicate that aging and longevity are subject to genetic regulation, but until fairly recently the identity of these genes was unknown. This has changed dramatically over the last ten years.
Huber Warner
core
Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group [PDF]
, 2015 Decline in cognitive abilities is a major concern in aging individuals. A potential important factor for functioning of the central nervous system in late-life stages is the KLOTHO (KL) gene.
Christensen, Kaare +5 more
core +2 more sources