Results 91 to 100 of about 13,098 (199)

Circulating Tumor DNA and Immune Response Markers for Improved Treatment Outcome Prediction in Diffuse Large B‐Cell Lymphoma: A Scoping Review

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Early identification of refractory disease remains a significant unmet clinical need in patients with diffuse large B‐cell lymphoma (DLBCL). This scoping review was conducted to assess the current knowledge on the use of circulating tumor DNA (ctDNA), either alone or in combination with immune markers, as predictive tools for treatment outcome
Ailin McMahon, Elizabeth J. Ryan, Sarah Dillon, Ruth Clifford   +3 more
wiley   +1 more source

Clinical and Molecular Findings of KMT2D-Related Kabuki Syndrome: A Series of 13 Patients With 3 Novel Variants.

European Journal of Medical Genetics
Kabuki syndrome (KS, #147920) is a rare genetic disorder characterized by postnatal growth deficiency, hypotonia, typical facial features, microcephaly, persistence of fetal fingertip pads, and intellectual disability.
Ayşe Burcu Doğan Arı, A. Türkyılmaz, Busranur Cavdarli, Esra Kılıç   +3 more
semanticscholar   +1 more source

Mechanisms of resistance to macrophage checkpoint inhibitors in B‐cell non‐Hodgkin lymphoma

British Journal of Haematology, EarlyView.
Zachary Hunzeker, Francisco Javier de la Rosa, Andrey Tyshevich, Darya Shavronskaya, Julia Alesse, Noel English, Lizzie Sheehan, Nikita Syzrantsev, Alexander Nesmelov, Hans‐Guido Wendel, Paolo Strati   +10 more
wiley   +1 more source

Comprehensive and integrative analysis of the KMT2D regulome

, 2017
Lysine (K)-specific methyltransferase 2D (KMT2D) is a critical component of epigenetic regulation through its role in mono-methylation of lysine 4 of histone H3 (H3K4me1). KMT2D is among the most frequently mutated genes in many forms of cancer, with particularly high occurrence of mutation in lymphoid malignancies.
openaire   +1 more source

Prognostic Significance of KMT2D Gene Mutation and Its Co-mutated Genes in Patients with Diffuse Large B-Cell Lymphoma

Zhongliu Fangzhi Yanjiu
ObjectiveTo explore the clinical characteristics of patients with diffuse large B-cell lymphoma (DLBCL) accompanied with KMT2D gene mutation and the impact of its co-mutated genes on prognosis.
Mutibaier·MIJITI, Xiaolong QI, Renaguli·ABULAITI, Wenxin TIAN, Sha LIU, Weiyuan MA, Zengsheng WANG, Li AN, Min MAO, Muhebaier·ABUDUER, Yan LI   +10 more
doaj   +1 more source

Identification of novel KMT2D mutations in two Chinese children with Kabuki syndrome: a case report and systematic literature review

BMC Medical Genetics, 2018
Background Kabuki syndrome (KS) is a rare pediatric congenital disorder with multiple congenital anomalies and intellectual disabilities, which is inherited in an autosomal dominant manner.
Chengqi Xin, Chun Wang, Yachen Wang, Jingyuan Zhao, Liang Wang, Runjie Li, Jing Liu   +6 more
doaj   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, Volume 13, Issue 44, 7 August 2026.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Dissecting diffuse large B‐cell lymphoma heterogeneity: New insights from a state‐specific molecular characterisation

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Integrating DNA and RNA sequencing with digital deconvolution, this study identifies five malignant B‐cell states in DLBCL with distinct mutational and microenvironmental profiles. These states predict survival independently of standard indices, revealing a critical dichotomy between favourable TME‐dependent (S1) and aggressive TME‐independent (S5 ...
Robel Papotti, Filippo Vit, Tamara Bittolo, Federico Pozzo, Stefania Bettelli, Samantha Pozzi, Luca Braglia, Elisa Forti, Arianna Di Napoli, M. Christina Cox, Tamar Tadmor, Pellegrino Musto, Leonardo Flenghi, Martina Quintini, Giovanna R. Mansueto, Sara Galimberti, Valentina Donati, Michele Spina, Alberto Zamò, Andreas Rosenwald, Riccardo Bomben, Stefano Sacchi, Valter Gattei   +22 more
wiley   +1 more source

KMT2D mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-induced regulatory T cell trafficking via FBXW7-NOTCH-MYC/TGF-β1 axis

International Journal on Biological Sciences
Histone methyltransferase KMT2D is one of the most frequently mutated genes in diffuse large B-cell lymphoma (DLBCL) and has been identified as an important pathogenic factor and prognostic marker.
Qing-Xiao Liu, Yue Zhu, H. Yi, Yi-Ge Shen, Li Wang, Shu Cheng, P. Xu, Haimin Xu, Lu Zhou, Yao-hui Huang, Chuan-Xin Huang, D. Fu, Meng-Meng Ji, Chao-fu Wang, Weili Zhao   +14 more
semanticscholar   +1 more source

SPP1‐driven spatial niche remodelling defines aggressive progression in the basal subtype of upper tract urothelial carcinoma

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Basal upper tract urothelial carcinoma has a largely stage‐independent immunestromal background that is spatially reorganized with muscle invasion into an SPP1‐associated myeloidstromal boundary program and a more heterogeneous angiogenic program.
Qi Zhang, Zhipeng Wen, Ziyang Yang, Xuezhi Long, Jieshen Xian, Yueting Huang, Yufei Liu, Yubo Wang, Jiahao Cheng, Gengjia Chen, Xuekun Zhang, Tuxiong Huang, Di Gu   +12 more
wiley   +1 more source