Results 161 to 170 of about 13,098 (199)

Adam13 interacts with large protein complexes to regulate histone modification and gene expression. [PDF]

Front Cell Dev Biol
Pandey A, Cousin H, Kumar S, Taylor L, Chander A, Coppenrath K, Shaidani NI, Horb M, Alfandari D.   +8 more
europepmc   +1 more source

Non-Isolated Dandy-Walker Malformation: Exome Sequencing Efficacy and Phenotypic Expansions. [PDF]

Clin Genet
Araji S, Zhao X, Rosenfeld JA, Lalani SR, Scott DA.   +4 more
europepmc   +1 more source

Abexinostat, a histone deacetylases inhibitor, for patients with relapsed or refractory follicular lymphoma: a multi-center, single-arm phase 2 study. [PDF]

Signal Transduct Target Ther
Gui L, Liu H, Wang H, Cao J, Li Y, Yu Y, Gao Y, Li Z, Shen J, Zhang L, Zhang Q, Pan H, Zheng M, Ke X, He H, Guo S, Wang Y, Xu X, Zou L, Wu W, Shi Y.   +20 more
europepmc   +1 more source

Multiple system atrophy is associated with brain somatic mutations in clonal hematopoiesis genes

Thompson B, Horner D, Morley C, Gustavsson E, Jaunmuktane Z, Proukakis C.   +5 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

KMT2D: A key emerging epigenetic regulator in head and neck diseases and tumors

Life Sciences
Histone modifications are critical determinants of chromatin accessibility and gene expression, both of which are intrinsically linked to human development and disease. Lysine methyltransferase 2D (KMT2D), a prominent member of the H3K4 methyltransferase
Kexin Wang, Fang Zhan, Xiaochen Yang, Mengyu Jiao, Peiyan Wang, Hui Zhang, Wei Shang, Jing Deng, Lin Wang   +8 more
exaly   +2 more sources

Deficiency of TET2-mediated KMT2D self-transcription confers a targetable vulnerability in hepatocellular carcinoma

PNAS Nexus
Hepatocellular carcinoma (HCC) has become a leading cause of cancer-related mortality worldwide. Conventional therapies tend to exacerbate comorbidities, liver dysfunction, and relapse, rendering an urgent demand for novel strategy for management of HCC.
Weiguang Yu, Yuting Jin, Jiaojiao Zheng   +2 more
exaly   +2 more sources

Small molecule inhibitors of the prostate cancer target KMT2D

Biochemical and Biophysical Research Communications, 2020
Histone lysine N-methyltransferase 2D (KMT2D), an important methyltransferase that is involved in the methylation of lysine 4 in histone H3 (H3K4) and related to the development of prostate cancer. Hypermethylation of H3K4 is shown in prostate cancer (PCa). However, KMT2D inhibitors have not yet been developed.
Guochao Liao, Zhongqiu Liu, Yu Qi
exaly   +3 more sources

Near complete deletion of KMT2D in a college student

American Journal of Medical Genetics Part A, 2022
AbstractPathogenic variants in KMT2D are typically associated with Kabuki syndrome (KS), a rare multisystem disorder. KS is characterized by facial dysmorphisms, intellectual disability, skeletal and dermatoglyphic differences, and poor growth. Seventy percent of individuals with clinically diagnosed KS have a confirmed pathogenic variant in KMT2D or ...
Catherine Gooch, Jaclyn Paige Souder, Matthew L. Tedder, Jennifer Kerkhof, Jennifer A. Lee, Raymond J. Louie, Bekim Sadikovic, Robin S. Fletcher, Nathaniel H. Robin   +8 more
openaire   +2 more sources

Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A–menin to bivalent promoters

Nature Genetics
Members of the KMT2C/D–KDM6A complex are recurrently mutated in urothelial carcinoma and in histologically normal urothelium. Here, using genetically engineered mouse models, we demonstrate that Kmt2c/d knockout in the urothelium led to impaired ...
Naitao Wang, Mohini R Pachai, Dan Li, Cindy J Lee, Sara Warda, Makhzuna N Khudoynazarova, W. Cho, Guojia Xie, Sagar R Shah, Li Yao, Cheng Qian, Elissa W. P. Wong, Juan Yan, Fanny Tomas, Wenhuo Hu, F. Kuo, S. Gao, Jiaqian Luo, Alison E. Smith, Ming Han, Dong Gao, Kai Ge, Haiyuan Yu, S. Chandarlapaty, Gopakumar V. Iyer, J. Rosenberg, D. Solit, H. Al-Ahmadie, P. Chi, Yu Chen   +29 more
semanticscholar   +1 more source