Modeled Subsidence of Permafrost Terrain 2025–2050: North‐Central Alaska
ABSTRACT A large fraction of the Alaska terrain is underlain by regolith that contains excess ice (ice that in volume exceeds the natural pore space). Possible loss of excess ice would lead to ground subsidence, which in turn would disturb and destabilize the ground surface.
Jaakko Putkonen +8 more
wiley +1 more source
Development and characterization of neutralizing monoclonal antibodies against clinically relevant human adenovirus subgroup B serotypes. [PDF]
Wang Y +13 more
europepmc +1 more source
Strategy for modular assembly of tetravalent, multispecific antibodies
Abstract Multispecific, multivalent antibodies (Abs) are a burgeoning class of drugs that dramatically expand the pharmacological repertoire beyond traditional therapeutic Abs. Here, we present a simple, modular approach to developing multispecific, multivalent Abs based on a Fab‐phage library with a single light chain.
Evan Mallette +12 more
wiley +1 more source
A Novel Chimeric Fiber-C4/D11 Subunit Vaccine Induces Cross-Neutralizing Antibodies and Provides Better Protection Against Fowl Adenovirus (FAdV) Type 4 and Type 11 Than the Fiber-D11/C4 Subunit Vaccine. [PDF]
Wang X +5 more
europepmc +1 more source
Building coiled coils with polar cores
Abstract Coiled coils are formed by α‐helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs‐into‐holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the helices.
Marcus D. Hartmann +3 more
wiley +1 more source
Recombinant adenoviruses application for cancer vaccines: from genetic design to clinical translation. [PDF]
Almarghalani NA +5 more
europepmc +1 more source
Azobenzene materials possess reversible photofluidization, promising for surface patterning. This review summarizes state‐of‐the‐art advances in azo‐material photofluidization, including photoisomerization mechanisms, molecular/polymer structural categories, emerging patterning applications, remaining challenges and future outlooks.
Jian Chen +4 more
wiley +1 more source
High-throughput engineering of bispecific antibodies to enhance macrophage-mediated cytotoxicity of B-cell lymphoma. [PDF]
Pagès-Geli C +13 more
europepmc +1 more source
Abstract The Mars 2020 rover is currently traversing the western rim of Jezero, a Middle to Late Noachian‐aged crater formed by an impactor that struck the northwest edge of Isidis Planitia (hereafter referred to as the Isidis basin) on Mars. Previous studies suggest that pre‐Isidis basin and Noachian outcrops are preserved throughout this region ...
M. C. Deahn +30 more
wiley +1 more source

