Results 121 to 130 of about 1,946 (137)

Knobs-into-Holes Packing of α-helices: Coiled Coils and Beyond

Biochemical Society Transactions, 2000
J. Walshaw, D. N. Woolfson
openaire   +1 more source

‘Knobs-into-holes’ provides a rational design strategy for engineering antibody CH3 domains for heavy chain heterodimerization

Immunotechnology, 1996
P. Carter, J.B.B. Ridgway, L.G. Presta
openaire   +1 more source

Optimization of an Automated Phage Display Workflow and Isolation of Fc Knob-into-Hole specific binders

Antibodies are one of the most important entities on the therapeutics market, where modified formats such as Fabs (fragment antigen binding), the bispecifics (bsAb), or VHHs (Nanobodies) gain more and more relevance in comparison to their parental IgG formats. This is due to their various advantageous traits. In particular, bsAbs provide an opportunity
openaire   +1 more source

Glycosylated, disulfide-linked Knob-into-Hole Fc fragment

, 2016
A. Kuglstatter, M. Stihle, J. Benz
openalex   +1 more source

Building better fibrin knob mimics: an investigation of synthetic fibrin knob peptide structures in solution and their dynamic binding with fibrinogen/fibrin holes

, 2010
Sarah E. Stabenfeldt, J. Jared Gossett, Thomas H. Barker   +2 more
openalex   +1 more source

Complexity of “A−a” Knob−Hole Fibrin Interaction Revealed by Atomic Force Spectroscopy

, 2008
Laurel E. Averett, Carri B. Geer, Ryan R. Fuierer, Boris B. Akhremitchev, Oleg V. Gorkun, Mark H. Schoenfisch   +5 more
openalex   +1 more source

Fc Knob-Hole Heterodimer T366W + T366S/L368A/Y407V

, 2015
S. Atwell, A. Leaver-Fay, K.J. Froning, H. Aldaz, A. Pustilnik, F. Lu, F. Huang, R. Yuan, S.H. Dhanani, A.K. Chamberlain, J.R. Fitchett, B. Gutierrez, J. Hendle, E. Secrist, S.J. Demarest, B. Kuhlman   +15 more
openalex   +1 more source

Bispecific antibody process development: Assembly and purification of knob and hole bispecific antibodies

, 2017
Glen Giese, Ambrose J. Williams, Maricel Rodriguez, Josefine Persson   +3 more
openalex   +1 more source

Antiparallel Conformation of Knob and Hole Aglycosylated Half-Antibody Homodimers Is Mediated by a CH2–CH3 Hydrophobic Interaction

, 2014
J. Michael Elliott, Mark Ultsch, Joshua Lee, Raymond Kai‐Yu Tong, Kentaro Takeda, Christoph Spiess, Charles Eigenbrot, Justin M. Scheer   +7 more
openalex   +1 more source

Crystal structure of knob-in-hole immunoglobulin G1 Fc heterodimer with P374A

W.S. Choi, C. Tilegenova, M. Are, A. Zwolak, P. Shaffer, S. Sharma   +5 more
openalex   +1 more source