Results 101 to 110 of about 739,130 (263)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
[Knockout Tricentennial Medal]
Medal commemorating San Antonio's Tricentennial from Knockout, a sports bar. The obverse resembles an yellow lotería card, named "Catina De Deportes". Details include three multicolored beer bottles, a soccer ball, basketball, football, boxing glove, and
core
Piezo1 Knockout Improves Post-Stroke Cognitive Dysfunction by Inhibiting the Interleukin-6 (IL-6)/Glutathione Peroxidase 4 (GPX4) Pathway [PDF]
Lujia Tang,* Di Xie,* Shangyuan Wang, Chengjin Gao, Shuming Pan Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, People’s Republic of China*These authors contributed equally to this
Xie D, Tang L, Pan S, Wang S, Gao C
core
CRISPR/Cas9-mediated inactivation of the soybean agglutinin Le1 gene to improve grain quality
Frontiers in Plant ScienceIntroductionSoybean agglutinin (SBA) is a major antinutritional factor in soybean seeds, reducing digestibility in monogastric animals. The Le1 gene encodes the primary lectin accumulated in seeds.
João Matheus Kafer +14 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Medal commemorating Fiesta 2019 from Knockout Sports Bar in San Antonio. The obverse is shaped in the form of a sugar skull. Details on the skull include the skyline of San Antonio, two soccer balls, a football, boxing gloves, and text reading "Knockout
core
, 2019 Zhong-Jie Lu,1 Qi Yu,2 Shui-Hong Zhou,2 Jun Fan,3 Li-Fang Shen,2 Yang-Yang Bao,2 Ting-Ting Wu,2 Min-Li Zhou,2 Ya-Ping Huang3 1Department of Radiotherapy, 2Department of Otolaryngology, 3State Key Laboratory for Diagnosis and Treatment of Infectious ...
Zhou ML +8 more
core
Generation of iNOS/dystrophin double knockout mice.
, 2013 A, Outline of the breeding scheme. Dystrophin and iNOS heterozygous male (Dys, Y/4cv; iNOS, +/−) and female (Dys, wt/4cv; iNOS, +/−) mice were generated by crossing iNOS knockout mice with mdx4cv mice.
Jin-Hong Shin (309178) +2 more
core +1 more source
IFNβ absence compensates for LAT functions in latency reactivation and T cell exhaustion
Journal of VirologyType I interferons (IFNs) generate strong antiviral immunity following viral infection in mice and humans. These type I IFNs are encoded by at least 14 IFNα genes and a single IFNβ gene.
Shaohui Wang +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source