Results 91 to 100 of about 739,130 (263)
Frontiers in PharmacologyBackgroundThe cannabinoid receptor 2 (CB2) is involved in regulating immune responses, yet its specific function in microglia remains poorly defined.
Kathryn J. Laloli +6 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 2018 Ascl1 knockout embryo analyzed at embryonic day E16.
Kazunori Sunadome (5396135) +25 more
core +1 more source
Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. [PDF]
, 2013 The p21-activated kinases are effector proteins for Rho-family GTPases. PAK4, PAK5, and PAK6 are the group II PAKs associated with neurite outgrowth, filopodia formation, and cell survival.
Audrey Minden +4 more
core +1 more source
Animal Cells and SystemsThe additional sex combs-like 1 (Asxl1) gene is a chromatin regulator involved in transcriptional activation and repression. While Asxl1 plays a crucial role in various organ development, its role in ocular development remains unclear.
Seungtae Moon +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Effect of knockout on OA disease model.
, 2016 The first and second column contain the effect of a knockout in the attractor basin. We check whether a knockout (either through the use of a small molecule inhibitor or by a genetic KO) indeed confers protection to OA, indicated as ‘protective ...
Jeroen Leijten (2835695) +5 more
core +1 more source
Exploring the Biocontrol Capability of Non-Mycotoxigenic Strains of Penicillium expansum
ToxinsPenicillium expansum is one the major postharvest pathogens of pome fruit during postharvest handling and storage. This fungus also produces patulin, which is a highly toxic mycotoxin that can contaminate infected fruits and their derived products and ...
Belén Llobregat +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
NOX4 knockout inhibits cell proliferation.
, 2017 (A) Proliferation of three NOX4 knockout cell lines was quantitated by MTT assay. HeLa control and knockout clones were seeded into 24 well plate and the MTT assay were performed in quadruplicate.
Minsu Jang (2817730) +7 more
core +1 more source