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Seminars in Cancer Biology, 1996
The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studied mechanisms that defends both ...
de Vries, A, van Steeg, H
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The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studied mechanisms that defends both ...
de Vries, A, van Steeg, H
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Knockout Mice in Xenobiotic Metabolism
Drug Metabolism Reviews, 2003Mice in which genes for drug metabolizing enzymes have been deleted or inactivated have great potential to further our understanding of the functions of these enzymes and their role in toxicology a...
Henderson, Colin J. +4 more
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Xenobiotic receptor knockout mice
Toxicology Letters, 1995Administration of certain foreign chemicals to animals elicits responses that are due to receptor-mediated activation of gene expression. Among the most well studied receptors are the Ah receptor (AHR) that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds and the peroxisome proliferator-activated receptors, PPARs, that mediate gene ...
F J, Gonzalez +4 more
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Rescue of Angiotensinogen-Knockout Mice
Biochemical and Biophysical Research Communications, 1998Angiotensinogen, the precursor of angiotensins I and II, is a critical component of the renin-angiotensin system that plays an important role in regulating blood pressure and electrolyte homeostasis. Genetically altered mice lacking angiotensinogen (Agt-KO) showed an expected phenotype, such as marked hypotension, but unexpected ones including abnormal
J, Ishida +9 more
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Generation of dynorphin knockout mice
Molecular Brain Research, 2001The opioid system has important roles in controlling pain, reward and addiction, and is implicated in numerous other processes within and outside the nervous system, such as mood states, immune responses, and prenatal developmental processes. The effects of the opioid system are mediated by at least three ligands, enkephalin, endorphin, and dynorphin ...
N, Sharifi +4 more
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Insulin Receptor Knockout Mice
Annual Review of Physiology, 2003▪ Abstract  To examine the role of the insulin receptor in fuel homeostasis, we and others have carried out genetic ablation studies in mice. Mice lacking insulin receptors are born with normal features, but develop early postnatal diabetes and die of ketoacidosis.
Tadahiro, Kitamura +2 more
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Impact of Knockout Mice in Toxicology
Critical Reviews in Toxicology, 1997Knockout mice obtained by homologous recombination technology may be valuable tools for in vivo investigations in toxicopathogenesis. A short review is given on the phenotype of mice with distinct deletions of cytokines and related genes. The application of these mice in pharmacological and toxicological research is discussed, with emphasis in ...
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Generation of Conditional Knockout Mice
2014Conditional knockout mouse models are powerful tools to examine the biological and molecular function(s) of genes in specific tissues. The general procedure to generate such genetically engineered mouse models consists of three main steps. The first step is to find the appropriate genomic clone of the gene of interest and to design the cloning and ...
Kazuhito, Sakamoto +2 more
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Genetic knockouts in mice: An update
Experientia, 1995Gene disruption technology in mammals, by homologous recombination in embryonic stem cells, is a powerful method to manipulate the mouse germ line. In the past decade it has produced a wealth of knowledge concerning neuronal development, neurodegenerative disorders and the roles of oncogenes, Hox genes and growth factors during development.
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Molecular Medicine Today, 1999
Gene targeting has become an extremely popular method for generating mouse models of human disease. The targeting event is carried out in vitro in pluripotent embryonic stem (ES) cells, which are then used to generate chimeric founder animals by either fusion with early-stage embryos or direct injection into donor blastocysts.
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Gene targeting has become an extremely popular method for generating mouse models of human disease. The targeting event is carried out in vitro in pluripotent embryonic stem (ES) cells, which are then used to generate chimeric founder animals by either fusion with early-stage embryos or direct injection into donor blastocysts.
openaire +1 more source