Results 241 to 250 of about 762,231 (296)

Reversing metabolic dysregulation in farnesoid X receptor knockout mice via gut microbiota modulation. [PDF]

PLoS One
Paraiso IL, Alcázar Magaña A, Alexiev A, Sharpton TJ, Maier CS, Kioussi C, Stevens JF.   +6 more
europepmc   +1 more source

Frem2 knockout mice exhibit Fraser syndrome phenotypes and neonatal lethality due to bilateral renal agenesis. [PDF]

Sci Rep
Simikyan RG, Zhang X, Strelkova O, Li N, Zhu M, Eckhard A, Baranov PY, Wu X, Richey L, Indzhykulian AA.   +9 more
europepmc   +1 more source

Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice. [PDF]

Sci Adv
Rocha AL, Schmedt C, Perkins G, Pinto A, Diedrich JK, Shan H, Plucińska K, Vieira de Souza E, Vaughan JM, Foster M, Sampath SC, Sampath SC, Cohen P, Ellisman MH, Saghatelian A.   +14 more
europepmc   +1 more source

Changes in Redox Balance and Mitochondrial Activity in the Retinas of Cystine/Glutamate Antiporter Knockout Mice. [PDF]

Invest Ophthalmol Vis Sci
Knight LJ, Martis RM, Donaldson PJ, Acosta ML, Lim JC.   +4 more
europepmc   +1 more source

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Xpaknockout mice

Seminars in Cancer Biology, 1996
The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studied mechanisms that defends both ...
de Vries, A, van Steeg, H
openaire   +3 more sources

Xenobiotic receptor knockout mice

Toxicology Letters, 1995
Administration of certain foreign chemicals to animals elicits responses that are due to receptor-mediated activation of gene expression. Among the most well studied receptors are the Ah receptor (AHR) that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds and the peroxisome proliferator-activated receptors, PPARs, that mediate gene ...
F J, Gonzalez, P, Fernandez-Salguero, S S, Lee, T, Pineau, J M, Ward   +4 more
openaire   +2 more sources

Insulin Receptor Knockout Mice

Annual Review of Physiology, 2003
▪ Abstract  To examine the role of the insulin receptor in fuel homeostasis, we and others have carried out genetic ablation studies in mice. Mice lacking insulin receptors are born with normal features, but develop early postnatal diabetes and die of ketoacidosis.
Tadahiro, Kitamura, C Ronald, Kahn, Domenico, Accili   +2 more
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Generating Conditional Knockout Mice

2010
Gene targeting in ES cells is extensively used to generate designed mouse mutants and to study gene function in vivo. Knockout mice that harbor a null allele in their germline provide appropriate genetic models of inherited diseases and often exhibit embryonic or early postnatal lethality. To study gene function in adult mice and in selected cell types,
Roland H, Friedel, Wolfgang, Wurst, Benedikt, Wefers, Ralf, Kühn   +3 more
openaire   +2 more sources

Generating Rab6 Conditional Knockout Mice

2021
RAB6 GTPase is the most abundant Golgi-associated RAB protein and regulates several transport steps at the level of this organelle. Homozygous Rab6a knockout (k/o) is embryonic lethal in mouse. To study RAB6 function in cell lineages and tissues, we thus generated various conditional Rab6a knockout (k/o) mice using the Cre/lox system.
Bardin, Sabine, Goud, Bruno
openaire   +2 more sources

Annexins – insights from knockout mice

Biological Chemistry, 2016
Abstract Annexins are a highly conserved protein family that bind to phospholipids in a calcium (Ca2+) – dependent manner. Studies with purified annexins, as well as overexpression and knockdown approaches identified multiple functions predominantly linked to their dynamic and reversible membrane binding behavior.
Thomas, Grewal, Sundeep J, Wason, Carlos, Enrich, Carles, Rentero   +3 more
openaire   +2 more sources