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Knockout Mouse Models of Iron Homeostasis
Annual Review of Nutrition, 2011Murine models have made valuable contributions to our understanding of iron metabolism. Investigation of mice with inherited forms of anemia has led to the discovery of novel proteins involved in iron homeostasis. A growing number of murine models are being developed to investigate mitochondrial iron metabolism.
Qi Feng +2 more
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Canavan Disease: Studies on the Knockout Mouse
2006Canavan disease (CD) is an autosomal recessive disorder, characterized by spongy degeneration of the brain. Patients with CD have aspartoacylase (ASPA) deficiency, which results accumulation of N-acetylaspartic acid (NAA) in the brain and elevated excretion of urinary NAA. Clinically, patients with CD have macrocephaly, mental retardation and hypotonia.
Stephen K. Tyring +4 more
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Movement disorders in the Hfe knockout mouse
Nutritional Neuroscience, 2005The Hfe(- /-) mouse is a model for human hereditary hemochromatosis (HHH). The accumulation of tissue iron in this condition has led to the suggestion that HHH patients may be at higher risk for neurodegenerative diseases. In this study, adult male Hfe(-/-) mice and wildtype controls (n = 12/group) were evaluated for impairment with motor tests (stride
Kevin C K Lloyd +5 more
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2001
Publisher Summary Telomeres are the ends of eukaryotic chromosomes and consist of tandem repeats of a G-rich DNA sequence, which in all the vertebrates is TTAGGG. Telomeres protect chromosome ends from degradation, recombination, and DNA repair activities.
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Publisher Summary Telomeres are the ends of eukaryotic chromosomes and consist of tandem repeats of a G-rich DNA sequence, which in all the vertebrates is TTAGGG. Telomeres protect chromosome ends from degradation, recombination, and DNA repair activities.
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Respiratory survival mechanisms in acetylcholinesterase knockout mouse
European Journal of Neuroscience, 2003AbstractCholinergic neurotransmission ensures muscle contraction and plays a role in the regulation of respiratory pattern in the brainstem. Inactivation of acetylcholinesterase (AChE) by organophosphates produces respiratory failure but AChE knockout mice survive to adulthood.
Chatonnet, Fabrice +6 more
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Fucosyltransferase-9 Knockout Mouse
2009Stage-specific embryonic antigen-1 (SSEA-1), an antigenic epitope of which was defined as a Lewis x [Lex: Galβ1–4(Fucα1–3)GlcNAc-] carbohydrate structure, is widely expressed on the surface of mammalian cells, and is considered to be involved in cell-cell interactions during embryogenesis, differentiation, and neurodevelopmental processes.
Hisashi Narimatsu, Takashi Kudo
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Mouse Models: Knockouts/Knockins
2010There is an enormous initiative to establish the genetic basis for addictive disorders. While forward genetic studies focus on identification of risk factors and protective genes impacting on addictive behaviors of humans and animal models, much effort is devoted to functions of these genes and polymorphisms relevant to substance abuse in reverse ...
Wenhao Xu, Weihua Huang, Ming D. Li
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Conditional Knockout Mouse Models of Cancer
Cold Spring Harbor Protocols, 2014In 2007, three scientists, Drs. Mario R. Capecchi, Martin J. Evans, and Oliver Smithies, received the Nobel Prize in Physiology or Medicine for their contributions of introducing specific gene modifications into mice. This technology, commonly referred to as gene targeting or knockout, has proven to be a powerful means for precisely manipulating the ...
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Immunosenescence phenotypes in the telomerase knockout mouse
Springer Seminars in Immunopathology, 2002Increasing generations of the telomerase knockout mouse, Terc-/-, show severe telomere dysfunction characterized by critically short telomeres and end-to-end chromosomal fusions. These mice also suffer from various age-related diseases affecting highly proliferative tissues. Among these pathologies are a reduced proliferative capacity of B and T cells,
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CRISPR/Cas9 genome editing technology has revolutionized the way to create animal disease models. Scientists have used this technique numerous times to study the effects of certain genes on the mouse genome. And knockout mice provide impressive insights into the internal workings of the human genome because of the similarity between mouse and human and
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