Results 61 to 70 of about 9,113,182 (295)
, 2019 In this short paper we introduce two main elements of a general methodology, called iTelos, for the management of knowledge diversity. The first is Knowledge Lotuses, a general purpose tool for the representation of knowledge diversity, while the second is a set of metrics which allow to quantify it, as it occurs within and across knowledge resources.
Giunchiglia, Fausto, Fumagalli, Mattia
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Biocultural diversity: a Mongolian case study
Ecology and Society, 2019 Although conceptual frameworks describing biodiversity and cultural keystone species have been widely accepted over the past 15 years, there remains a need for an overarching framework that covers the various components of biocultural diversity.
Barbara C. Seele +2 more
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Knowledge Graph Embedding with Diversity of Structures
Proceedings of the 26th International Conference on World Wide Web Companion - WWW '17 Companion, 2017 In recent years, different web knowledge graphs, both free and commercial, have been created. Knowledge graphs use relations between entities to describe facts in the world. We engage in embedding a large scale knowledge graph into a continuous vector space.
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Journal of Ethnobiology and EthnomedicineBackground Hybrid knowledge systems are central to community negotiations of environmental, social, and epistemic pressures. In multilingual borderland areas, interactions between local ecological knowledge (LEK), formal, and popular knowledge systems ...
Julia Prakofjewa +6 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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