Results 71 to 80 of about 224,412 (257)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Determinants of Preschool Teachers' Knowledge-Sharing Behavior from a Thinking Style Perspective. [PDF]

Behav Sci (Basel), 2023
Cheng L, Wu D, Cao J.
europepmc   +1 more source

Assessing the relationship between supervisor knowledge sharing and innovative behaviors among clinical nurses: the mediating role of organizational learning

BMC Nursing
Background In today’s rapidly evolving healthcare environment, nurses’ innovative behaviors are crucial for improving patient care quality and organizational effectiveness.
Nima Gharajeh-Alamdari, Alireza Mirzaei, Saeid Mehri, Aghil Habibi Soola   +3 more
doaj   +1 more source

Explore Knowledge-Sharing Strategy and Evolutionary Mechanism for Integrated Project Team Based on Evolutionary Game Model

Advances in Civil Engineering, 2019
Integrated Project Delivery (IPD) has become increasingly popular in the architecture, engineering, and construction industries. However, the current practice status by the construction industry fails to deliver the desired results. In that backdrop, how
Yanchao Du, Hengyu Zhou, Yongbo Yuan, Xiaoxue Liu   +3 more
doaj   +1 more source

A study on the effects of college students' knowledge-sharing behavior on group performance and individual social status. [PDF]

Front Psychol, 2023
Jia L, Liang Z, Lei C, Huang L.
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Knowledge sharing among medical teachers: the interplay between personality and the theory of planned behavior

BMC Medical Education
Introduction Knowledge sharing is critical to the quality of medical education and healthcare services. However, medical teachers encounter multiple barriers, such as content dispersion and a lack of shared knowledge management. Using structural equation
Hatam Faraji Dehsorkhi, Ali Asghar Hayat
doaj   +1 more source

THE ROLE OF MOTIVATIONAL LANGUAGE AS A MODERATION BETWEEN VARIOUS BEHAVIOR KNOWLEDGE OF WORK BEHAVIOR INNOVATIVE AND JOB SATISFACTION

Jurnal Ilmiah Bisnis dan Ekonomi Asia
The purpose of this study was to explore the extent to which the influence of knowledge sharing behavior on innovative work behavior and employee job satisfaction with motivational language as a moderating variable.
Mai Yuliza, Elfitra Azliyanti, Ferry Siswadhi   +2 more
doaj   +1 more source