Results 51 to 60 of about 1,788,745 (325)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot

Biology, 2020
Autophagy is a highly conserved degradation mechanism that is essential for maintaining cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and there is immense interest in targeting autophagy for therapeutic approaches.
Magali Humbert, María Morán, Patricia de la Cruz-Ojeda, Jordi Muntané, Tabea Wiedmer, Nadezda Apostolova, Sharon L. McKenna, Guillermo Velasco, Walter Balduini, Leopold Eckhart, Bassam Janji, Belém Sampaio-Marques, Paula Ludovico, Eva Žerovnik, Rupert Langer, Aurel Perren, Nikolai Engedal, Mario P. Tschan   +17 more
doaj   +1 more source

Robust language pair-independent sub-tree alignment [PDF]

, 2007
Data-driven approaches to machine translation (MT) achieve state-of-the-art results. Many syntax-aware approaches, such as Example-Based MT and Data-Oriented Translation, make use of tree pairs aligned at sub-sentential level.
Hearne, Mary, Tinsley, John, Way, Andy, Zhechev, Ventsislav   +3 more
core  

The Contribution of Conceptual Frameworks to Knowledge Translation Interventions in Physical Therapy [PDF]

, 2014
Context: There is growing recognition of the importance of knowledge translation activities in physical therapy to ensure that research findings are integrated in clinical practice, and increasing numbers of knowledge translation interventions are ...
Gervais, Mathieu-Joël, Hudon, Anne, Hunt, Matthew   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Perceptions of Pediatric Nephrologists regarding Timing of Dialysis Initiation in Children in Canada

Canadian Journal of Kidney Health and Disease, 2016
Background: Significant practice variation exists in Canada with respect to timing of dialysis initiation in children. In the absence of evidence to guide practice, physicians' perceptions may significantly influence decision-making.
Jeremy A. Saban, Michael Zappitelli, Susan M. Samuel, Manish M. Sood, R. Todd Alexander, Steven Arora, Robin L. Erickson, Kristine Kroeker, Braden J. Manns, Allison B. Dart   +9 more
doaj   +1 more source

Pregnant women’s views on how to promote the use of a decision aid for Down syndrome prenatal screening: a theory-informed qualitative study

BMC Health Services Research, 2018
Background For pregnant women and their partners, the decision to undergo Down syndrome prenatal screening is difficult. Patient decision aids (PtDA) can help them make an informed decision.
Titilayo Tatiana Agbadjé, Matthew Menear, Michèle Dugas, Marie-Pierre Gagnon, Samira Abbasgholizadeh Rahimi, Hubert Robitaille, Anik M. C. Giguère, François Rousseau, Brenda J. Wilson, France Légaré   +9 more
doaj   +1 more source

Implemented machine learning tools to inform decision-making for patient care in hospital settings: a scoping review

BMJ Open, 2023
Objectives To identify ML tools in hospital settings and how they were implemented to inform decision-making for patient care through a scoping review.
Sharon E Straus, Andrea C Tricco, Sonia M Thomas, P Alison Paprica, Vera Nincic, Marco Ghassemi, Amanda Parker, Areej Hezam, Charmalee Harris, Orna Fennelly, Jessie McGowan   +10 more
doaj   +1 more source

Knowledge, lost in translation [PDF]

Journal of the Royal Society of Medicine, 2011
The pursuit of knowledge is no longer enough for clinicians. We have to absorb it, communicate it and, most importantly, translate it. Typically, like other core skills that clinicians have never been taught properly, knowledge translation is something of a mystery.
openaire   +2 more sources