Results 11 to 20 of about 190 (147)

Effect of difelikefalin, a selective kappa opioid receptor agonist, on respiratory depression: A randomized, double-blind, placebo-controlled trial. [PDF]

Clin Transl Sci, 2021
Abstract Difelikefalin, a selective kappa opioid receptor agonist designed to limit central nervous system (CNS) penetration, is under development for the treatment of pruritus. Its hydrophilic, small‐peptidic structure limits CNS entry, minimizing potential CNS‐mediated adverse events (AEs).
Viscusi ER, Torjman MC, Munera CL, Stauffer JW, Setnik BS, Bagal SN.   +5 more
europepmc   +2 more sources

In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions. [PDF]

Pharmacol Res Perspect, 2022
Mechanistic static pharmacokinetic models predict that CYP450 inhibition and induction are unlikely for fenfluramine or its major metabolite norfenfluramine at doses used for seizure reduction (0.2−0.7 mg/kg/day). These results suggest minimal drug‐drug interaction perpetrator potential for either fenfluramine or norfenfluramine.
Martin P, Czerwiński M, Limaye PB, Ogilvie BW, Smith S, Boyd B.   +5 more
europepmc   +2 more sources

In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions. [PDF]

Pharmacol Res Perspect, 2022
Reaction phenotyping showed metabolism of the antiseizure medication fenfluramine by recombinant human cytochrome P450 (rCYP) enzymes rCYP2B6, rCYP1A2, rCYP2C19, and rCYP2D6. Fenfluramine dose may need to be adjusted when co‐administered with strong inhibitors or inducers of these enzymes (e.g., stiripentol).
Martin P, Czerwiński M, Limaye PB, Muranjan S, Ogilvie BW, Smith S, Boyd B.   +6 more
europepmc   +2 more sources

Nie tylko Bulla gnieźnieńska. O znaczeniu dokumentu fundacyjnego Zbyluta (1153) dla polskich badań historycznojęzykowych

LingVaria, 2023
NOT ONLY BULL OF GNIEZNO: ON THE IMPORTANCE OF ZBYLUT’S FOUNDATION DOCUMENT (1153) FOR POLISH HISTORICAL AND LINGUISTIC RESEARCH. PART 3: TOWARDS TRANSCRIPTION This article is the third part of a series dedicated to the documents sharing the name of ...
Marcin Kuźmicki, Tomasz Mika
doaj   +1 more source

Nie tylko Bulla gnieźnieńska

LingVaria, 2021
Not Only Bulla Gnieźnieńska. On the Importance of Zbylut’s Foundation Document (Issued in 1153) for Polish Historical and Linguistic Research. Part 1: Research Object The list of sources used in the research of the oldest period of development of the ...
Tomasz Mika
doaj   +1 more source

Nie tylko Bulla gnieźnieńska. O znaczeniu dokumentu fundacyjnego Zbyluta (1153) dla polskich badań historycznojęzykowych

LingVaria, 2022
NOT ONLY BULLA GNIEŹNIEŃSKA: ON THE IMPORTANCE OF ZBYLUT’S FOUNDATION DOCUMENT (ISSUED IN 1153) FOR POLISH HISTORICAL AND LINGUISTIC RESEARCH: PART 2: THE RELATIONSHIP BETWEEN VERSIONS OF THE DOCUMENT This article is the second part of a series.
Marcin Kuźmicki, Tomasz Mika
doaj   +1 more source

DEA, balanced scorecard and intellectual capital including the gender dimension: A comprehensive list of indicators

International Transactions in Operational Research, Volume 30, Issue 6, Page 2972-3012, November 2023., 2023
Abstract One of the most significant problems in the development of quantitative models to assess the performance of decision‐making units (DMUs) is the availability of information coded into variables and indicators that are proxies for the relevant dimensions of the models: resources or inputs, products or services or outputs, and heterogeneous ...
Cinzia Daraio, Simone Di Leo, Gianpaolo Iazzolino, Domenico Laise   +3 more
wiley   +1 more source

Overseas imports on the Blue Nile: Chemical compositional analysis of glass beads from Soba, Nubia

Archaeometry, Volume 65, Issue 5, Page 1018-1031, October 2023., 2023
Abstract Archaeological evidence as well as textual sources leave no doubt about Alwa's (Alodia's) intense transcultural connections, further corroborated by understudied overseas glass bead imports found there. This paper presents results of an analysis of 23 glass beads from Soba, the most prosperous capital of medieval Nubia.
Joanna Then‐Obłuska, Laure Dussubieux
wiley   +1 more source

Agro‐morphological characterization and diversity analysis of Coffea arabica germplasm collection from INIA, Peru

Crop Science, Volume 63, Issue 5, Page 2877-2893, September/October 2023., 2023
Abstract Coffee (Coffea arabica L.) plays a major role in the economy of Peru and the world. The present study aims to elucidate the agro‐morphological variability of coffee genotypes maintained in the National Institute of Agrarian Innovation (INIA) germplasm collection.
Richard Paredes‐Espinosa, Dina L. Gutiérrez‐Reynoso, Diego Atoche‐Garay, Pedro Javier Mansilla‐Córdova, Yudi Abad‐Romaní, Carolina Girón‐Aguilar, Itala Flores‐Torres, Ana Gabriela Montañez‐Artica, Carlos I. Arbizu, Carlos A. Amasifuen Guerra, Jorge L. Maicelo Quintana, Carlos Poemape, Juan Carlos Guerrero‐Abad   +12 more
wiley   +1 more source

Beads for the nomads of late antiquity: Chemical characterization of glass from the Blemmyan tumuli at Kalabsha, Nubia, of the mid‐fourth century CE

Archaeometry, Volume 63, Issue 6, Page 1255-1271, December 2021., 2021
The mobility of the Blemmyes between the Nile Valley and the Red Sea coast, and their skill in trading, are well attested in the literary sources and in the archaeological record. While they operated mainly in the Eastern Desert, their cemeteries, dated to the mid‐fourth century ce, were located in the strategic region of the Dodekaschoinos of Lower ...
J. Then‐Obłuska, L. Dussubieux
wiley   +1 more source