Results 151 to 160 of about 24,464,352 (186)

Comparative genomic study of bla_KPC-2-carrying multidrug-resistant Klebsiella pneumoniae in the United Arab Emirates. [PDF]

Sci Rep
Ghazawi A, Elbediwi M, Pal T, Sonnevend A, Manzoor A, Habib I, Al-Marzooq F, Senok A, Poirel L, Khan M.   +9 more
europepmc   +1 more source

Genomic and functional characterization of ST11-KL64 hypervirulence-associated carbapenem-resistant <i>Klebsiella pneumoniae</i> co-harboring <i>bla</i> _KPC-2 and <i>bla</i> _NDM-13. [PDF]

Front Microbiol
Chen H, Liu L, Huang L, Huang J, Li T, Huang X, He Q.   +6 more
europepmc   +1 more source

Comprehensive genomic analysis of carbapenem-resistant Citrobacter freundii and characterization of a co-carrying bla_KPC-2 and bla_NDM-1 isolate in Zhejiang Province， China. [PDF]

BMC Microbiol
Luo X, Zheng Y, Ye J, Lan J, Chen H, Jin Y, Zhang J, Duan D.   +7 more
europepmc   +1 more source

Erratum: High Prevalence of KPC-2-Producing Hypervirulent Klebsiella pneumoniae Causing Meningitis in Eastern China [Corrigendum]. [PDF]

Infect Drug Resist
europepmc   +1 more source

Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan [PDF]

Clinical Microbiology and Infection, 2015
We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan.
Hung-Jen Tang, Y -C Chuang, M-C Chang
exaly   +2 more sources

A multidisciplinary approach to the design of novel inhibitors for KPC-2

, 2017
Background. The emergence and dissemination of multi drug resistant (MDR) Gram-negative pathogens resistant to all available antibiotics poses a significant threat in clinical therapy. Among them, Klebsiella Pneumoniae clinical isolates overexpressing KPC-2 carbapenemase are the most worrisome, extending bacterial resistance to last resort carbapenems.
Celenza, Giuseppe, Bellio, Pierangelo, LINCIANO, PASQUALE, Perilli, Mariagrazia, Cendron, Laura, TONDI, Donatella   +5 more
openaire   +2 more sources

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Large hospital outbreak of KPC-2-producing Klebsiella pneumoniae: investigating mortality and the impact of screening for KPC-2 with polymerase chain reaction

Journal of Hospital Infection, 2015
Multi-drug-resistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing K. pneumoniae are an increasing cause of healthcare-associated infections worldwide.To investigate the impact of clinical infection on mortality, and examine the effect of use of KPC-2-specific polymerase chain reaction (PCR) on the time to contact isolation during an outbreak ...
T, Ducomble, S, Faucheux, U, Helbig, U X, Kaisers, B, König, A, Knaust, C, Lübbert, I, Möller, A C, Rodloff, B, Schweickert, T, Eckmanns   +10 more
openaire   +2 more sources

Boronic acid inhibitors of the class A β-lactamase KPC-2

Bioorganic & Medicinal Chemistry, 2018
The rapid rise of antimicrobial resistance is one of the greatest challenges currently facing medical science. The most common cause of resistance to β-lactam antibiotics is the expression of β-lactamase enzymes, such as KPC-2. As such the development of novel inhibitors of KPC-2 and related enzymes is of the upmost importance. We report the design and
Jingyuan Zhou, Paul Stapleton, Shozeb Haider, Jess Healy   +3 more
openaire   +2 more sources

Enterobacteriaceae producing the KPC-2 carbapenemase from hospital sewage

Diagnostic Microbiology and Infectious Disease, 2012
Fifteen isolates with reduced susceptibility to meropenem were obtained from hospital sewage. They contained bla(KPC-2) and belonged to multiple clones of Citrobacter freundii or Enterobacter cloacae. bla(KPC-2) was commonly carried by self-transmissible plasmids with different EcoRI-restricted patterns. Tn2 was identified upstream of bla(KPC-2), while
Xinzhuo, Zhang, Xiaoju, Lü, Zhiyong, Zong   +2 more
openaire   +2 more sources