Results 141 to 150 of about 85,174 (277)

In Vitro Activity of Meropenem-Vaborbactam against Clinical Isolates of KPC-Positive Enterobacteriaceae

Antimicrobial Agents and Chemotherapy, 2017
Vaborbactam (formerly RPX7009) is a novel inhibitor of serine β-lactamases, including Ambler class A carbapenemases, such as KPCs. The current study evaluated the in vitro activity of the combination agent meropenem-vaborbactam against a global ...
M. Hackel, O. Lomovskaya, M. Dudley, J. Karlowsky, D. Sahm   +4 more
semanticscholar   +1 more source

Gut Microbiota as a Key Modulator in the Pathophysiology of Sepsis: SURVEIL Project

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Longitudinal profiling of 132 hospitalized patients reveals that age, colonization status, and sepsis interact to shape gut microbiota diversity and composition. Sepsis is associated with reduced alpha diversity, beta‐diversity shifts, functional predictions (methanogenesis, nitrate/sulfate respiration), and partial MDR overlap with bloodstream ...
Chiara Bazzano, Alice Caramaschi, Nadia Massa, Silvio Collani, Marta Mellai, Nadia Barizzone, Andrea Rocchetti, Paolo Bottino, Maria Simona Caroppo, Valeria Bonato, Rosanna Vaschetto, Sara Scaglione, Alessia Francese, Narges Gholami, Claudio Caria, Paola Bianchi, Cristiano Lauritano, Luigi Castello, Annalisa Roveta, Antonio Maconi, Stefano Andreoni, Sandra Dalfonso, Elisa Bona   +22 more
wiley   +1 more source

Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque, Aymeric Jacquemin, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet   +4 more
wiley   +1 more source

Wastewater‐Based Assessment of Antimicrobial Resistance and Bacterial Communities in Urban and Rural Areas in the Province of Trento (Italy)

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Wastewater from urban and rural areas was analyzed to investigate antimicrobial‐resistant bacteria and resistance genes. ESBL‐Escherichia coli and genes coding for clinically relevant resistances, namely, those to macrolides, carbapenems, and vancomycin, were higher in urban than in rural areas.
Maya Petricciuolo, Agnese Carnevali, Alessia Torboli, Mattia Postinghel, Alessia Guasticchi, Paola Foladori, Maria Cadonna, Ermanno Federici   +7 more
wiley   +1 more source

Minimum Evolution tree of amino acid sequences for KPC-2 to KPC-17.

, 2014
KPC-15 carbapenemase was our newly discovered and appeared to be homogenous with KPC-4 closely. The amino acid sequences of KPCs based on the data of Figure 1. This comparison was designed and analysed using MEGA 5.05 software.
Linjun Yang (652707), Dongguo Wang (652706), Jiayu Chen (106469), Yonghua Mou (652708), Yijun Yang (187046)   +4 more
core   +1 more source

Acute mastoiditis caused by Klebsiella pneumoniae carbapenemase (KPC) producing bacteria – an atypical cause

GMS Hygiene and Infection Control
Aim: The aim of this report is to present a rare case of acute mastoiditis caused by Klebsiella (K.) pneumoniae carbapenemase (KPC) producing bacteria. Methods: The following report describes a 78-year-old immunosuppressed female who was hospitalized ...
Aristos Aristodimou, Zacharias Raptopoulos, Georgios Georgiou, Elena Xenofontos, Loukia Dramiotou   +4 more
doaj   +1 more source

Gut Microbiota Alterations Associated With Colonization by Multidrug‐Resistant Organisms in ICU Patients: First Systematic Review and Meta‐Analysis

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Microbiota profiling showed colonized critically ill patients had lower values of dominance/evenness (Simpson's index) and richness (Observed), reaching significantly lower values of information (mean difference in Shannon index = –1.18; 95% CI, –1.84 to –0.52; p < 0.001).
Andra‐Elena Goicea, Daniel‐Corneliu Leucuța, Constantin Bodolea   +2 more
wiley   +1 more source

Jet Feedback on kpc Scales: A Review

Galaxies
Relativistic jets from AGN are an important driver of feedback in galaxies. They interact with their environments over a wide range of physical scales during their lifetime, and an understanding of these interactions is crucial for unraveling the role of supermassive black holes in shaping galaxy evolution.
openaire   +2 more sources

Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae

Antimicrobial Agents and Chemotherapy, 2017
Vaborbactam (formerly RPX7009) is a new β-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Klebsiella pneumoniaecarbapenemases (KPC). It has been developed in combination with meropenem.
Dongxu Sun, Debora Rubio-Aparicio, Kirk J. Nelson, M. Dudley, O. Lomovskaya   +4 more
semanticscholar   +1 more source

Detection and Characterization of ESBL‐Producing and Carbapenem‐Resistant Klebsiella pneumoniae in Ornamental Birds and Their Surrounding Environments

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Multidrug‐resistant ESBL‐ and carbapenem‐resistant Klebsiella pneumoniae were identified from ornamental birds, their handlers and surrounding environments, carrying key virulence and resistant genes, highlighting potential One Health transmission risks between animals, humans and the associated environments.
Md Abdullah Evna Hasan, Md. Liton Rana, Md Saiful Islam, Sadia Afrin Punom, Md. Tabeer Hossain Antor, Diruba Akter Jany, Naeem Ahammed Ibrahim Fahim, S M Abu Sama Al Faruquee, Md. Raisul Islam, Zuhayr Bakhtiyar, Anindita Ash Prome, Md. Monirul Islam, Saifur Rahman, Mohammad Ferdousur Rahman Khan, Md. Tanvir Rahman   +14 more
wiley   +1 more source