Results 131 to 140 of about 886,470 (223)

Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential

Frontiers in Cardiovascular Medicine, 2018
The role of inflammation in vascular disease is well recognized, involving dysregulation of both circulating immune cells as well as the cells of the vessel wall itself.
David R. Sweet, David R. Sweet, Liyan Fan, Liyan Fan, Paishiun N. Hsieh, Paishiun N. Hsieh, Mukesh K. Jain   +6 more
doaj   +1 more source

The Role of sptf-3 in C. elegans Growth and Development [PDF]

, 2011
The Sp family of transcription factors has important functions during development in animals. In the nematode Caenorhabditis elegans there are three Sp-related transcription factors (Sptf) which perform similarly important roles in development.
Ulm, Elizabeth
core  

Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS.

European Heart Journal, 2019
AIMS To assess the functional relevance and therapeutic potential of the pro-angiogenic long non-coding RNA MANTIS in vascular disease development. METHODS AND RESULTS RNA sequencing, CRISPR activation, overexpression, and RNAi demonstrated that MANTIS,
M. Leisegang, Sofia-Iris Bibli, S. Günther, Beatrice Pflüger-Müller, James A. Oo, Cindy Höper, S. Seredinski, Michail Yekelchyk, T. Schmitz-Rixen, C. Schürmann, Jiong Hu, M. Looso, F. Sigala, R. Boon, I. Fleming, R. Brandes   +15 more
semanticscholar   +1 more source

An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death. [PDF]

, 2016
Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, which encodes the extracellular matrix protein fibrillin-1.
Bernard, William George, Granata, Alessandra, Low, Lucinda, McNamara, Madeline, Sastry, Priya, Serrano, Felipe, Sinha, Sanjay   +6 more
core   +1 more source

Hyperhomocysteinemia induces vascular calcification by activating the transcription factor RUNX2 via Krüppel-like factor 4 up-regulation in mice

Journal of Biological Chemistry, 2019
One of the main characteristics of atherosclerosis is vascular calcification, which is linked to adverse cardiovascular events. Increased homocysteine (Hcy), a feature of hyperhomocysteinemia, is correlated with advanced vascular calcification and ...
Lili Zhu, N. Zhang, Ru Yan, Wenjuan Yang, Guangzhi Cong, Ning Yan, Wanrui Ma, Jianjun Hou, Libo Yang, S. Jia   +9 more
semanticscholar   +1 more source

Occurrence and Significance of the Nuclear Transcription Factor Krüppel-Like Factor 4 (KLF4) in the Vessel Wall

Acta Medica, 2009
Practically all mammalian cells including human can switch, according to micro- or macroenvironmental conditions, from states of cellular quiescence to inflammatory activation and vice versa.
Pavel Kuneš, Zdeňka Holubcová, Jan Krejsek   +2 more
doaj   +1 more source

Role of Krüppel-like Factor 4-p21CIP1 Axis in Breast Cancer Stem-like Cell Inhibition by Benzyl Isothiocyanate

Cancer Prevention Research, 2019
Cancer chemoprevention by benzyl isothiocyanate (BITC), which is derived from cruciferous vegetables like garden cress, in a transgenic mouse model of breast cancer is associated with inhibition of breast cancer stem-like cells (bCSC), but the molecular ...
Su-Hyeong Kim, Shivendra V. Singh
semanticscholar   +1 more source

Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis

Nature Communications, 2018
While being known as a transcription factor, Kruppel-like factor 4 (Klf4) may have other molecular functions. This study shows that Klf4 in neural progenitor cells regulate neurogenesis and self-renewal by interacting with RNA-binding protein Staufen1 ...
Byoung-San Moon, Jinlun Bai, Mingyang Cai, Chunming Liu, Jiandang Shi, Wange Lu   +5 more
doaj   +1 more source

Hydroa Vacciniforme Lymphoproliferative Disorder With a Truncating KLF2 Variant Presenting as Benign Photodermatoses

Photodermatology, Photoimmunology &Photomedicine, Volume 42, Issue 3, May 2026.
John Warner‐Levy, Angelia Ong, Nina Farquharson, Jean Ayer   +3 more
wiley   +1 more source

KLF5 aggravates osteoarthritis progression by inhibiting chondrocyte autophagy via transcriptional activation of PLK2

Scientific Reports
This study aims to investigate the regulatory role of the Krüppel-like factor 5 (KLF5)/Polo-like kinase 2 (PLK2) axis in osteoarthritis (OA) and its effects on chondrocyte function. An OA mouse model was established.
Bin Wang, Hongliang Zhang, Zhiyong Fan, Haoye Shi, Feiyang Huang, Hua Zhang   +5 more
doaj   +1 more source