Results 111 to 120 of about 886,470 (223)

miR-7-5p regulates the proliferation and migration of colorectal cancer cells by negatively regulating the expression of Krüppel-like factor 4

Oncology Letters, 2019
Previous studies have demonstrated that microRNA-7-5p (miR-7-5p) functions as a tumor suppressor in certain types of human cancer. However, the role of miR-7-5p in colorectal cancer (CRC) remains to be investigated.
Mingjun Dong, Yangyang Xie, Yidong Xu
semanticscholar   +1 more source

Circular RNAs: Unlocking new avenues in cardiometabolic disease management

The Journal of Physiology, EarlyView.
Abstract figure legend In the heart circular RNAs (circRNAs) function as microRNA sponges, interact with proteins and can even undergo translation. Advances in bioinformatics now enable their identification through high‐throughput RNA sequencing, whereas computational analyses reveal differential expression in cardiac disease settings.
Kimberley M. Mellor, Thomas D. Donelly, Gerald L.M. Naepi, Glenn D. Wadley, Bianca C. Bernardo   +4 more
wiley   +1 more source

Gene expression profiling of KLF4 and KLF5 in visceral adipose tissue of obese women: insights into adipogenic and metabolic regulation

Lipids in Health and Disease
Background As global obesity rates rise, women are disproportionately affected, placing them at elevated risk for both metabolic dysfunction and cardiovascular complications.
Dalya Jamal Muhi, Maher Mohammed Murad, Ghodratollah Panahi, Hossein Zabihi-Mahmoudabadi, Solaleh Emamgholipour, Azin Nowrouzi   +5 more
doaj   +1 more source

Kruppel-like factor 6 regulates transforming growth factor-beta gene expression during human respiratory syncytial virus infection [PDF]

, 2011
Background Human respiratory syncytial virus (RSV) infection is associated with airway remodeling and subsequent asthma development. Transforming growth factor-beta (TGF) plays a crucial role in asthma development.
Victoria Mgbemena, Jesus A Segovia, Te-Hung Chang, Santanu Bose   +3 more
core   +1 more source

Concise Review: Regulation of Self‐Renewal in Normal and Malignant Hematopoietic Stem Cells by Krüppel‐Like Factor 4

Stem Cells Translational Medicine, 2019
Pluripotent and tissue‐specific stem cells, such as blood‐forming stem cells, are maintained through a balance of quiescence, self‐renewal, and differentiation.
C. Park, A. Lewis, Taylor J. Chen, Daniel Lacorazza   +3 more
semanticscholar   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation

Journal of Neuroinflammation, 2010
Background Activation of microglia, the resident macrophages of the central nervous system (CNS), is the hallmark of neuroinflammation in neurodegenerative diseases and other pathological conditions associated with CNS infection.
Das Sulagna, Gupta Malvika, Kaushik Deepak K, Basu Anirban   +3 more
doaj   +1 more source

Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome. [PDF]

, 2018
Background:Acute kidney injury (AKI) commonly occurs in patients with sepsis and acute respiratory distress syndrome (ARDS). Objective:To investigate whether statin treatment is protective against AKI in sepsis-associated ARDS.
Hsu, Raymond K, Levitt, Joseph E, Liu, Kathleen D, Matthay, Michael A, Thompson, Boyd Taylor, Truwit, Jonathon D   +5 more
core   +3 more sources

Kruppel‐like factor 6 and miR‐223 signaling axis regulates macrophage‐mediated inflammation

The FASEB Journal, 2019
Macrophage‐mediated inflammation is an explicitly robust biologic response that plays a critical role in maintaining tissue homeostasis by eliminating deleterious agents.
Gun-Dong Kim, H. Ng, Nibedita Patel, Ganapati H. Mahabeleshwar   +3 more
semanticscholar   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source