Results 101 to 110 of about 886,470 (223)

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, EarlyView.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

Secretome analysis of breast cancer-associated adipose tissue to identify paracrine regulators of breast cancer growth [PDF]

, 2017
Adipose tissue secretes a plethora of adipokines as evidenced by characterization of subcutaneous and visceral adipose tissue secretomes. However, adipose tissue composition and secretion pattern is depot and disease dependent, influencing the adipose ...
Bracke, Marc, Braems, Geert, Cocquyt, Veronique, De Wever, Olivier, Denys, Hannelore, Hendrix, An, Lapeire, Lore, Lecoutere, Evelyne, Maynard, Dawn, Müller, Cathérine, Van Bockstal, Mieke, Van den Broecke, Rudy, Vandesompele, Jo   +12 more
core   +2 more sources

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes [PDF]

, 2015
Insect nephrocytes are highly endocytic scavenger cells that represent the only invertebrate model for the study of human kidney podocytes. Despite their importance, nephrocyte development is largely uncharacterised.
A Halme, AC Crossley, Achim Paululat, AD Alvarez, AJ Vilella, AS Tutor, B Wang, BB McConnell, C Burnett, C Lehmacher, D Das, D Das, D Jeyaraj, D Jeyaraj, D Leiss, DA Kimbrell, EJ Ward, F Grahammer, F Zhang, GG Neely, H Weavers, HY Lim, J Sellin, J Sellin, James H. Catterson, Jessica R. Ivy, JH Catterson, JL Brown, Karen Ocorr, KK Sorensen, LJ Zhu, M Helmstadter, M Togel, Maik Drechsler, P Tomancak, Paul S. Hartley, Q He, Rolf Bodmer, Ruben Artero, S Fisch, S Haralalka, S Zaffran, S Zhuang, SE McGuire, SF Soukup, SK Aggarwal, SK Mallipattu, SK Sasse, VB Wigglesworth, VR Chintapalli, VY Arshavsky, X Gao, Z Han, Z Han   +53 more
core   +7 more sources

Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo [PDF]

, 2016
Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of ...
Berek, Jonathan S, Chung, Young Min, Hu, Mickey C-T, Ma, Jessica, Park, See-Hyoung, Yang, Qin   +5 more
core   +2 more sources

Krüppel‐like factor 4 regulates stemness and mesenchymal properties of colorectal cancer stem cells through the TGF‐β1/Smad/snail pathway

Journal of Cellular and Molecular Medicine, 2019
Krüppel‐like factor 4 (KLF4) was closely associated with epithelial‐mesenchymal transition and stemness in colorectal cancer stem cells (CSCs)‐enriched spheroid cells. Nonetheless, the underlying molecular mechanism is unclear.
Zhengwei Leng, Yong Li, Guojun Zhou, X. Lv, W. Ai, Jian-shui Li, Lingmi Hou   +6 more
semanticscholar   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

Differential expression of Krüppel-like factor 4 and 5 in oral carcinomas and involvement in the epithelial-mesenchymal transition [PDF]

, 2014
日本歯科大学201
柴田 征紀
core  

Multimodal transcriptional control of pattern formation in embryonic development [PDF]

, 2020
Predicting how interactions between transcription factors and regulatory DNA sequence dictate rates of transcription and, ultimately, drive developmental outcomes remains an open challenge in physical biology.
Galstyan, Vahe, Garcia, Hernan G., Lammers, Nicholas C., Medin, Sean A., Reimer, Armando, Wiggins, Chris H.   +5 more
core   +1 more source

Untersuchungen zur Rolle des Transkriptionsfaktors "Krueppel-like factor 4" in der Sertoli-Zelle der Maus [PDF]

, 2006
Der Zinkfinger-Transkriptionsfaktor "Krueppel-like factor 4" (Klf4) wird in Epithelzellen vieler Gewebe, wie z.B. des Darms, des Magens und der Haut stark exprimiert.
Godmann, Maren, Renkawitz-Pohl, Renate (Prof. Dr.)   +1 more
core   +1 more source