Results 81 to 90 of about 886,470 (223)

コッカクケイ　サイボウ　ニ　オケル　テンシャ　インシ　Krüppel-Like　Factor　4　ノ　サヨウ　カイセキ [PDF]

Material from: 'Fujikawa, J., Tanaka, M., Itoh, S., et al., Kruppel-like factor 4 expression in osteoblasts represses osteoblast-dependent osteoclast maturation, Cell and Tissue Research, published 2014, Springer ...
フジカワ, ジュンジ, 藤川, 順司   +1 more
core   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Krüppel-Like Factor 5 Promotes Lung Tumorigenesis through Upregulation of Sox4

Cellular Physiology and Biochemistry, 2014
Background: Krüppel-like factor 5 (KLF5), a member of zinc finger class of DNA-binding transcriptional regulators, has attracted attention because of its important regulatory activities linked to diverse functions such as cell growth, proliferation ...
Qi Li, Zhao Dong, Fei Zhou, Xun Cai, Yong Gao, Li-Wei Wang   +5 more
doaj   +1 more source

Role of the 3' untranslated region in the post-transcriptionnal regulation of KLF6 gene expression in hepatocellular carcinoma [PDF]

, 2013
Krüppel-like factor 6 (KLF6) a été identifié comme gène suppresseur de tumeur impliqué dans le contrôle de la croissance, de la différentiation cellulaire et dans la mort par apoptose.
Diab, Thoria
core  

β‐Aminoisobutyric Acid Alleviates Cisplatin‐Induced Muscle Atrophy by Regulating E3 Ubiquitin Ligases, Apoptosis, Amino Acid Metabolism, Autophagy, and Ferroptosis

Medicine Bulletin, EarlyView.
ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang, Wen‐Bi He, Huan Wang, Hao Wang, Wen‐Jun Fang, Meng‐Qian Li, Jiong‐Xing Huang, Fei‐Peng Chen, Hui‐Guo Wang, Lin Zhu, Xiao‐Guang Liu   +10 more
wiley   +1 more source

Shear stress regulation of miR-93 and miR-484 maturation through nucleolin. [PDF]

, 2019
Pulsatile shear (PS) and oscillatory shear (OS) elicit distinct mechanotransduction signals that maintain endothelial homeostasis or induce endothelial dysfunction, respectively.
Chen, Lili, Chen, Shanshan, Chien, Shu, Gongol, Brendan, Han, Yue, He, Ming, Huang, Po-Hsun, Johnson, David A, Kang, Jian, Li, Jie, Li, Yi-Shuan, Liu, Jun-Hui, Lytle, Christian, Marin, Traci, Martin, Marcy, Shyy, John Y-J, Sun, Wei, Wang, Shen-Chih, Zhang, Jiao   +18 more
core  

Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients [PDF]

, 2017
Background: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still ...
Ali, Bassam R., Chondrou, Vasiliki, John, Anne, Kastrinou, Vlasia, Katsila, Theodora, Kolovos, Petros, Kourakli, Alexandra, Papachatzopoulou, Adamantia, Patrinos, George P., Pavlidaki, Alexia, Sgourou, Argyro, Symeonidis, Argiris   +11 more
core   +5 more sources

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma

Neoplasia: An International Journal for Oncology Research, 2010
Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown. We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in medulloblastoma using high-resolution
Yukiko Nakahara, Paul A. Northcott, Meihua Li, Paul N. Kongkham, Christian Smith, Hai Yan, Sidney Croul, Young-Shin Ra, Charles Eberhart, Annie Huang, Darell Bigner, Wesia Grajkowska, Timothy Van Meter, James T. Rutka, Michael D. Taylor   +14 more
doaj   +1 more source

Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice [PDF]

, 2011
F-box and WD repeat domain-containing 7α (Fbw7α) is the substrate recognition component of a ubiquitin ligase that controls the degradation of factors involved in cellular growth, including c-Myc, cyclin E, and c-Jun.
Ema Masatsugu, Iwasaki Hitoshi, Karasawa Tadayoshi, Kobayashi Kazuto, Kumadaki Shin, Matsuzaka Takashi, Nakagawa Yoshimi, Nakakuki Masanori, Saito Ryo, Shimano Hitoshi, Sone Hirohito, Suzuki Hiroaki, Takahashi Akimitsu, Takahashi Satoru, Takekoshi Kazuhiro, Yahagi Naoya, Yamada Nobuhiro, Yatoh Shigeru, 中川 嘉, 依馬 正次, 小林 和人, 山田 信博, 岩﨑 仁, 島野 仁, 曽根 博仁, 松坂 賢, 矢作 直也, 矢藤 繁, 竹越 一博, 鈴木 浩明, 高橋 昭光, 高橋 智   +31 more
core   +1 more source