Results 61 to 70 of about 886,470 (223)

The Clinical Relevance and Function of Krüppel-Like Factor 16 in Breast Cancer

Cancer Management and Research, 2020
Background Krüppel-like factor 16 (KLF16), a member of the KLF family, is involved in metabolism and regulation of the endocrine system and has emerging roles in tumor progression.
S. Bang, Junhong Li, Meiqin Zhang, Renjie Cui, Xingwen Wu, Zhaochen Xin, Duan Ma, Jin Zhang, Hongwei Zhang   +8 more
semanticscholar   +1 more source

Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia.

Journal of Clinical Investigation, 2019
Chronic glucocorticoid therapy has serious side effects, including diabetes and fatty liver. However, the molecular mechanisms responsible for steroid-induced diabetes remain largely enigmatic. Here, we show that hepatic Krüppel-like factor 9 (Klf9) gene
An-fang Cui, H. Fan, Yinliang Zhang, Yu-jie Zhang, D. Niu, Shuainan Liu, Quan Liu, Wei Ma, Z. Shen, Lian Shen, Yanling Liu, Huabing Zhang, Yuan Xue, Ying Cui, Qinghua Wang, Xinhua Xiao, Fude Fang, Jichun Yang, Qinghua Cui, Yongsheng Chang   +19 more
semanticscholar   +1 more source

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

Advanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli, Andrea Pianetti, Elena Mancinelli, Anthea Villano, Matteo Vailati, Paola Lagonegro, Miryam Criado‐Gonzalez, Montserrat Climent, Hansel Comas‐Rojas, Leonardo Elia, Francesco Moccia, Gabriele Tullii, Maria Rosa Antognazza   +12 more
wiley   +1 more source

Role of Klf4 in the Regulation of Apoptosis and Cell Cycle in Rat Granulosa Cells during the Periovulatory Period [PDF]

, 2019
In the ovary, the luteinizing hormone (LH) surge suppresses the proliferation and induces the luteinization of preovulatory granulosa cells (GCs), which is crucial for the survival of terminally-differentiated GCs.
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core   +1 more source

KLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy

Autophagy, 2019
Macroautophagy/autophagy is involved in myeloid cellular repair, destruction, and osteoclast differentiation; conversely, KLF2 (kruppel-like factor 2 [lung]) regulates myeloid cell activation and differentiation.
Dipranjan Laha, Moonmoon Deb, H. Das
semanticscholar   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Glucosamine impedes transforming growth factor β1-mediated corneal fibroblast differentiation by targeting Krüppel-like factor 4

Journal of Biomedical Science, 2019
Background Transforming growth factor (TGF) family members play important roles in the regulation of corneal integrity, and the pathogenesis of corneal fibrosis.
Ying-Jen Chen, Shih-Ming Huang, Ming-Cheng Tai, Jiann-Torng Chen, Chang-Min Liang   +4 more
doaj   +1 more source

Genregulatorische und funktionelle Analysen des differentiell exprimierten rolling pebbles Transkriptes rols6 zeigen, dass das Rols6 Protein für die vollständige Differenzierung der Malpighischen Gefäße in Drosophila melanogaster notwendig ist. [PDF]

, 2004
Die Kommunikation zwischen zwei Zellpopulationen, Zell-Migration und -Adhäsion sind in der Entwicklung der Malpighischen Gefäße (MpG) wie auch in der Muskelentwicklung von Drosophila melanogaster während der Myoblastenfusion essentielle biologische ...
Pütz, Michael, Renkawitz-Pohl, Renate (Prof. Dr.)   +1 more
core   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation

Journal of Neuroinflammation, 2012
Background Neuroinflammation occurs as a result of microglial activation in response to invading micro-organisms or other inflammatory stimuli within the central nervous system.
Kaushik Deepak, Mukhopadhyay Rupanjan, Kumawat Kanhaiya, Gupta Malvika, Basu Anirban   +4 more
doaj   +1 more source