Results 51 to 60 of about 886,470 (223)

High expression of Krüppel‐like factor 5 is associated with poor prognosis in patients with colorectal cancer

Cancer Science, 2020
Krüppel‐like factor 5 (KLF5) plays an oncogenic role and has diverse functions in cancer cells. However, correlation between KLF5 and clinical outcome has not been determined in patients with colorectal cancer and colorectal liver metastasis.
Y. Takagi, N. Sakai, H. Yoshitomi, K. Furukawa, T. Takayashiki, S. Kuboki, S. Takano, D. Suzuki, S. Kagawa, T. Mishima, Eri Nakadai, H. Miyauchi, H. Matsubara, M. Ohtsuka   +13 more
semanticscholar   +1 more source

Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. [PDF]

PLoS ONE, 2012
Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine.
Tianxin Yu, Xi Chen, Wen Zhang, Juan Li, Ren Xu, Timothy C Wang, Walden Ai, Chunming Liu   +7 more
doaj   +1 more source

Kruppel‐like factor 6 promotes macrophage inflammatory and hypoxia response

The FASEB Journal, 2020
Macrophages are the professional phagocytes that protect the host from infection or injury. Tissue microenvironment at the site of injury and inflammation is characterized by low oxygen concentration and poor supply of nutrients.
Gun-Dong Kim, H. Ng, E. Chan, Ganapati H. Mahabeleshwar   +3 more
semanticscholar   +1 more source

The Involvement of Krüppel-like Factors in Cardiovascular Diseases

Life, 2023
Krüppel-like factors (KLFs) are a set of DNA-binding proteins belonging to a family of zinc-finger transcription factors, which have been associated with many biological processes related to the activation or repression of genes, inducing cell growth ...
Michelle G. Santoyo-Suarez, Jimena D. Mares-Montemayor, Gerardo R. Padilla-Rivas, Juan Luis Delgado-Gallegos, Adriana G. Quiroz-Reyes, Jorge A. Roacho-Perez, Diego F. Benitez-Chao, Lourdes Garza-Ocañas, Gilberto Arevalo-Martinez, Elsa N. Garza-Treviño, Jose Francisco Islas   +10 more
doaj   +1 more source

Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]

, 2019
BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda, Farias-Eisner, Robin, Nava, Miguel, Vadgama, Jaydutt V, Wu, Yanyuan, Zemke, Nathan R   +5 more
core   +5 more sources

Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation

Nature Communications, 2020
Substantial evidence implicates crosstalk between metabolic tissues and the immune system in the inception and progression of obesity. However, molecular regulators that orchestrate metaflammation both centrally and peripherally remains incompletely ...
David R. Sweet, Neelakantan T. Vasudevan, Liyan Fan, Chloe E. Booth, K. Keerthy, Xudong Liao, Vinesh Vinayachandran, Y. Takami, Derin Tugal, N. Sharma, E. Chan, Lilei Zhang, Yulan Qing, S. Gerson, Chen Fu, A. Wynshaw-Boris, Panjamaporn Sangwung, Lalitha Nayak, P. Holvoet, Keiichiro Matoba, Yuan Lu, Guangjin Zhou, M. Jain   +22 more
semanticscholar   +1 more source

KLF4 suppresses the proliferation and metastasis of NSCLC cells via inhibition of MSI2 and regulation of the JAK/STAT3 signaling pathway

Translational Oncology, 2022
Background: Non-small cell lung cancer (NSCLC) remains an aggresive tumor with poor survival rates. Krüppel-like factor 4 (KLF4) is known to be involved in progression of NSCLC; however, the detailed mechanism by which KLF4 regulates the progression of ...
Di-Di Luo, Feng Zhao
doaj   +1 more source

Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance In pregnancy, blood vessels in the uterus increase in size, providing more blood supply and nutrients to the growing fetus. Corin is an enzyme that boosts this process.
Can Wang, Zhiting Wang, Meiling He, Tiantian Zhou, Yayan Niu, Shengxuan Sun, Hui Li, Ce Zhang, Shengnan Zhang, Meng Liu, Ying Xu, Ningzheng Dong, Qingyu Wu   +12 more
semanticscholar   +1 more source

Regulation of delta-aminolevulinic acid dehydratase by krüppel-like factor 1. [PDF]

PLoS ONE, 2012
Krüppel-like factor 1(KLF1) is a hematopoietic-specific zinc finger transcription factor essential for erythroid gene expression. In concert with the transacting factor GATA1, KLF1 modulates the coordinate expression of the genes encoding the multi ...
Aurelie D Desgardin, Tatiana Abramova, Tolulope O Rosanwo, Sreedharan Kartha, Eun-Hee Shim, Stephen M Jane, John M Cunningham   +6 more
doaj   +1 more source

The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo [PDF]

, 2012
The CACCC-box binding protein erythroid Kruppel-like factor (EKLF/KLF1) is a master regulator that directs the expression of many important erythroid genes.
Borg J, Coghill E, Eaton SA, Enomoto T, Feng WC, Hancock D, Henderson NC, Hodge D, Nuez B, Paulson RF, Pearson R, Pearson RC, Perkins AC, Sears DA, Shi Y, Socolovsky M, Tallack MR, Tallack MR, Turner J, Turner J, Vu TT, Zhang J, Zhang W   +22 more
core   +1 more source