Results 31 to 40 of about 886,470 (223)

Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway. [PDF]

, 2017
Recent studies have linked branched-chain amino acid (BCAA) with numerous metabolic diseases. However, the molecular basis of BCAA's roles in metabolic regulation remains to be established.
Dong, Weibing, Liu, Yunxia, Shao, Jing, Sun, Haipeng, Wang, Yibin, Zhou, Meiyi   +5 more
core   +2 more sources

Expression profiling of migrated and invaded breast cancer cells predicts early metastatic relapse and reveals Krüppel-like factor 9 as a potential suppressor of invasive growth in breast cancer [PDF]

, 2013
Cell motility and invasion initiate metastasis. However, only a subpopulation of cancer cells within a tumor will ultimately become invasive. Due to this stochastic and transient nature, in an experimental setting, migrating and invading cells need to be
Croes, Lieselot, De Wever, Olivier, De Wilde, Annemieke, Dirix, Luc, Lardon, Filip, LIMAME, RIDHA, Op de Beeck, Ken, Pauwels, Patrick, Peeters, Marc, Van Camp, Guy, Van Laere, Steven   +10 more
core   +3 more sources

Krüppel like factor 4 promoter undergoes active demethylation during monocyte/macrophage differentiation.

PLoS ONE, 2014
The role of different lineage specific transcription factors in directing hematopoietic cell fate towards myeloid lineage is well established but the status of epigenetic modifications has not been defined during this important developmental process.
Manjula Karpurapu, Ravi Ranjan, Jing Deng, Sangwoon Chung, Yong Gyu Lee, Lei Xiao, Teja Srinivas Nirujogi, Jeffrey R Jacobson, Gye Young Park, John W Christman   +9 more
doaj   +1 more source

Kruppel-like factor 8 regulates triple negative breast cancer stem cell-like activity

Frontiers in Oncology, 2023
IntroductionBreast tumor development is regulated by a sub-population of breast cancer cells, termed cancer stem-like cells (CSC), which are capable of self-renewing and differentiating, and are involved in promoting breast cancer invasion, metastasis ...
Giang Le Minh, Emily M. Esquea, Tejsi T. Dhameliya, Jessica Merzy, Mi-Hye Lee, Lauren E. Ball, Mauricio J. Reginato, Mauricio J. Reginato   +7 more
doaj   +1 more source

Hepatic Krüppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance

Gut, 2020
Objective Impaired hepatic fatty acids oxidation results in lipid accumulation and redox imbalance, promoting the development of fatty liver diseases and insulin resistance. However, the underlying pathogenic mechanism is poorly understood.
Nannan Sun, Chuangpeng Shen, Lei Zhang, Xiaojie Wu, Yuanyuan Yu, Xiaoying Yang, Chen Yang, Chong Zhong, Zhao Gao, Wei Miao, Zehong Yang, Weihang Gao, Lingjiao Hu, Kevin W. Williams, Changhui Liu, Yongsheng Chang, Yong Gao   +16 more
semanticscholar   +1 more source

Krüppel-Like Factor 4 Is a Regulator of Proinflammatory Signaling in Fibroblast-Like Synoviocytes through Increased IL-6 Expression

Mediators of Inflammation, 2016
Human fibroblast-like synoviocytes play a vital role in joint synovial inflammation in rheumatoid arthritis (RA). Proinflammatory cytokines induce fibroblast-like synoviocyte activation and dysfunction.
Xinjing Luo, Jie Chen, Jianwei Ruan, Yongfeng Chen, Xuanrong Mo, Jiangwen Xie, Guoju Lv   +6 more
doaj   +1 more source

Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus

Gynecological Endocrinology, 2022
Objectives This study aims to determine serum levels of human Krüppel-like factors (KLFs), sP-selectin and sE-selectin and establish correlations between them in patients with gestational diabetes mellitus (GDM).Methods Twenty-six GDM patients aged ...
Hongmei Zhang#, Zhigao Chen#, Xiaoling Wang   +2 more
doaj   +1 more source

Hypoxic Cancer-Secreted Exosomal miR-182-5p Promotes Glioblastoma Angiogenesis by Targeting Kruppel-like Factor 2 and 4

Molecular Cancer Research, 2020
Glioblastoma (GBM) is the most lethal primary brain tumor and has a complex molecular profile. Hypoxia plays a critical role during tumor progression and in the tumor microenvironment (TME).
Junjun Li, Hongliang Yuan, Hao Xu, Hongyang Zhao, N. Xiong   +4 more
semanticscholar   +1 more source

Kruppel-like factor 4 inhibits non–small cell lung cancer cell growth and aggressiveness by stimulating transforming growth factor-β1-meidated ERK/JNK/NF-κB signaling pathways

Tumor Biology, 2017
Non–small cell lung cancer is one of the most common epithelial tumors that cause the most common cancer-related mortality due to invasive ability. Research has found that Kruppel-like factor 4, a zinc-finger transcription factor, plays a critical role ...
Renzhi Yu, Lei Han, Xin Ni, Minghuan Wang, Ping Xue, Li Zhang, Mei Yuan   +6 more
doaj   +1 more source

Krüppel -Like Factor 8 is a Stress-Responsive Transcription Factor that Regulates Expression of HuR

Cellular Physiology and Biochemistry, 2014
Background/Aims: HuR is an RNA-binding protein that regulates the post-transcriptional life of thousands of cellular mRNAs and promotes cell survival. HuR is expressed as two mRNA transcripts that are differentially regulated by cell stress.
Suman Govindaraju, Beth S. Lee
doaj   +1 more source