Results 11 to 20 of about 886,470 (223)

Glucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages. [PDF]

Nat Commun
The mechanisms underlying glucocorticoid (GC)-induced obesity are poorly understood. Macrophages are the primary targets by which GCs exert pharmacological effects and perform critical functions in adipose tissue homeostasis.
Zhang Y, Du C, Wang W, Qiao W, Li Y, Zhang Y, Sheng S, Zhou X, Zhang L, Fan H, Yu Y, Chen Y, Liao Y, Chen S, Chang Y.   +14 more
europepmc   +2 more sources

Deletion of Krüppel-like factor-4 promotes axonal regeneration in mammals

Neural Regeneration Research, 2021
Axonal regeneration plays an important role in functional recovery after nervous system damage. However, after axonal injury in mammals, regeneration is often poor.
Jin-Hui Xu, Xu-Zhen Qin, Hao-Nan Zhang, Yan-Xia Ma, Shi-Bin Qi, Hong-Cheng Zhang, Jin-Jin Ma, Xin-Ya Fu, Ji-Le Xie, Saijilafu   +9 more
doaj   +2 more sources

A Krüppel-like factor establishes cellular heterogeneity during schistosome tegumental maintenance. [PDF]

PLoS Pathogens
Schistosomes are blood dwelling parasitic flatworms that can survive in the circulation of their human hosts for decades. These parasites possess a unique syncytial skin-like surface tissue known as the tegument that is thought to be uniquely adapted for
Lu Zhao, George R Wendt, James J Collins Iii   +2 more
doaj   +2 more sources

Krüppel‐like factor 4 transcription factor in blood–brain barrier endothelial cells: A potential role in Alzheimer's disease [PDF]

Animal Models and Experimental Medicine
Alzheimer's disease is the most prevalent chronic neurodegenerative disorder worldwide, with no sufficient cure. Ongoing research is focused on developing new therapies aimed at preventing or delaying the onset of symptoms, slowing disease progression ...
Ziying Wei, Chunhua Liu, Jianyu Chen, Yuxiao Yao, Dajiang Qin   +4 more
doaj   +2 more sources

Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle [PDF]

Molecular Metabolism
Regular physical activity induces a variety of health benefits, preventing and counteracting diseases caused by a sedentary lifestyle. However, the molecular underpinnings of skeletal muscle plasticity in exercise remain poorly understood.
Konstantin Schneider-Heieck, Joaquín Pérez-Schindler, Jonas Blatter, Laura M. de Smalen, Wandrille Duchemin, Stefan A. Steurer, Bettina Karrer-Cardel, Danilo Ritz, Christoph Handschin   +8 more
doaj   +2 more sources

Krüppel-like factor 2 (KLF2), a potential target for neuroregeneration [PDF]

Neural Regeneration Research
Surajit Hansda, Prateeksha Prateeksha, Hiranmoy Das   +2 more
doaj   +2 more sources

Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis

Annals of the Rheumatic Diseases, 2022
Objectives Analysing expression patterns of Krüppel-like factor (KLF) transcription factors in normal and osteoarthritis (OA) human cartilage, and determining functions and mechanisms of KLF4 and KLF2 in joint homoeostasis and OA pathogenesis.
M. Kawata, Takeshi Teramura, Philip Ordoukhanian, S. Head, P. Natarajan, Aishwarya Sundaresan, M. Olmer, H. Asahara, M. Lotz   +8 more
semanticscholar   +1 more source

Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Krüppel-Like Factor 4)

Arteriosclerosis, Thrombosis and Vascular Biology, 2021
Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to contract and relax, thus modulating blood flow. They also play a crucial role
Carmen Yap, Arnout Mieremet, C. D. de Vries, D. Micha, V. de Waard   +4 more
semanticscholar   +1 more source

Krüppel-like factor 15 integrated autophagy and gluconeogenesis to maintain glucose homeostasis under 20-hydroxyecdysone regulation

PLoS Genetics, 2022
The regulation of glycometabolism homeostasis is vital to maintain health and development of animal and humans; however, the molecular mechanisms by which organisms regulate the glucose metabolism homeostasis from a feeding state switching to a non ...
Xiao-Pei Wang, Zhenhao Huang, Yan-Li Li, Ke-Yan Jin, Du-Juan Dong, Jin-Xing Wang, Xiao-Fan Zhao   +6 more
semanticscholar   +1 more source

Loss of proximal tubular transcription factor Krüppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidation.

Kidney International, 2021
Loss of fatty acid β-oxidation (FAO) in the proximal tubule is a critical mediator of acute kidney injury and eventual fibrosis. However, transcriptional mediators of FAO in proximal tubule injury remain understudied.
S. Piret, Ahmed A Attallah, Xiangchen Gu, Yiqing Guo, Nehaben A. Gujarati, Justina Henein, A. Zollman, T. Hato, Avi Ma’ayan, M. Revelo, K. Dickman, Chung-Hsin Chen, C. Shun, T. Rosenquist, J. He, S. Mallipattu   +15 more
semanticscholar   +1 more source