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Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis. [PDF]

Cancers (Basel), 2023
Simple Summary Krüppel-like Factor-9 (KLF9) and Krüppel-like Factor-13 (KLF13) are highly related proteins that function as inducers and/or repressors of specific target gene repertoires in a variety of tissues and in diverse pathophysiological states ...
Simmen FA, Alhallak I, Simmen RCM.
europepmc   +2 more sources

Krüppel-like Factor 2 (KLF2) in Immune Cell Migration

Vaccines, 2021
Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell
Jens Wittner, Wolfgang Schuh
doaj   +2 more sources

Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors

Frontiers in Cell and Developmental Biology, 2021
Krüppel-like factor 6 (KLF6) is one of the most studied members of the specificity protein/Krüppel-like factor (SP/KLF) transcription factor family. It has a typical zinc finger structure and plays a pivotal role in regulating the biological processes of
Kang Hu, Qing-Kang Zheng, Rui-Jie Ma, Chao Ma, Zhi-Gang Sun, Nan Zhang   +5 more
doaj   +2 more sources

Krüppel-Like Factor 1: A Pivotal Gene Regulator in Erythropoiesis

Cells, 2022
Krüppel-like factor 1 (KLF1) plays a crucial role in erythropoiesis. In-depth studies conducted on mice and humans have highlighted its importance in erythroid lineage commitment, terminal erythropoiesis progression and the switching of globin genes from
Cristian Antonio Caria, Valeria Faà, Maria Serafina Ristaldi   +2 more
doaj   +2 more sources

Overexpression of Krüppel-Like Factor 4 Suppresses Migration and Invasion of Non-Small Cell Lung Cancer Through c-Jun-NH2-Terminal Kinase/Epithelial-Mesenchymal Transition Signaling Pathway

Frontiers in Pharmacology, 2020
Krüppel-like factor 4 (KLF4) is a transcription factor and plays a vital role in cancer initiation and development. However, the role of Krüppel-like factor 4 in the metastasis of non-small cell lung cancer (NSCLC) is not clear.
Yanping Wu, Lianjun Lin, Xiang Wang, Yong Li, Zhonghui Liu, Wei Ye, Weiming Huang, Gang Lin, Haibo Liu, Jixin Zhang, Ting Li, Beilei Zhao, Liping Lv, Jian Li, Nanping Wang, Xinmin Liu   +15 more
doaj   +2 more sources

Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment [PDF]

Cancer Medicine
Objective Krüppel‐like factor 4 (KLF4) is a zinc finger transcription factor that plays context‐dependent roles in cancer. It functions as either a tumor suppressor or an oncogene depending on tumor type and cellular context.
Min Tang, Binle Tian, Jingyi Zhou, Di Ma, Rongze Sun, Qi Li   +5 more
doaj   +2 more sources

Krüppel-like factor 4 control of immune cell function [PDF]

Frontiers in Immunology
Krüppel-like factor 4 (KLF4) belongs to a family of transcription factors that contain conserved zinc finger DNA binding domains, including specificity proteins (SPs) and Krüppel-like factors (KLFs).
Tapatee Das, Elaine Wang, Yitian Xu, Harrison Yang, Xudong Liao, Mukesh K. Jain, Mukesh K. Jain   +6 more
doaj   +2 more sources

Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury

Journal of Neuroinflammation, 2022
Background The long-term functional recovery of traumatic brain injury (TBI) is hampered by pathological events, such as parenchymal neuroinflammation, neuronal death, and white matter injury.
Chao Zhou, Ping Sun, Milton H. Hamblin, Ke-Jie Yin   +3 more
doaj   +2 more sources

Krüppel like factor 7 regulates mitochondrial dynamics balance in myocardial infarction [PDF]

Communications Biology
Targeting the balance of mitochondrial fission and fusion can effectively alleviate the cardiac energy supply efficiency, to restore cardiac systolic dysfunction and reduce mortality.
Cao Wang, Fuxing Zhu, Lan Zhou, Situo Zhang, Ruiqi Wang, Hui Tian, Bosong Zhang, Jiahui Wu, Xiang Xu, Ruixian Jiang, Xiaolu Hou, Jian Liu, Weiming Tian   +12 more
doaj   +2 more sources

Molecular function of Krüppel-like factor 7 in biology [PDF]

Acta Biochimica et Biophysica Sinica, 2023
Krüppel-like factor 7 ( KLF7), also named ubiquitous KLF ( UKLF) based on its ubiquitous expression in adult human tissues, is a conserved gene in animals.
Mao Yi, Chen Yuechan, Zhang Zhiwei
doaj   +2 more sources