Results 21 to 30 of about 886,470 (223)

Krüppel-like factor 6–mediated loss of BCAA catabolism contributes to kidney injury in mice and humans

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The kidney proximal tubule is particularly susceptible to acute injury, which results in loss of fatty acid oxidation (FAO), their primary energy source.
S. Piret, Yiqing Guo, Ahmed A Attallah, Sylvia J Horne, A. Zollman, Daniel Owusu, Justina Henein, Viktoriya S. Sidorenko, M. Revelo, T. Hato, Avi Ma’ayan, J. He, S. Mallipattu   +12 more
semanticscholar   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease [PDF]

, 2016
BACKGROUND: Small airway remodeling is an important cause of the airflow limitation in chronic obstructive pulmonary disease (COPD). A large population of patients with COPD also have pulmonary hypertension.
Abe, K, Hashimoto, Y, Ichikawa, T, Ichinose, M, Kikuchi, T, Koarai, A, Numakura, T, Okazaki, T, Onodera, K, Sato, K, Sugiura, H, Tamada, T, Tanaka, R, Yamada, M, Yanagisawa, S   +14 more
core   +4 more sources

Cardiomyocyte Krüppel-like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy.

Circulation, 2021
Background: We previously showed that cardiomyocyte Krüppel-like factor (KLF)-5 regulates cardiac fatty acid oxidation. As heart failure has been associated with altered fatty acid oxidation, we investigated the role of cardiomyocyte KLF5 in lipid ...
Matthew Hoffman, D. Palioura, I. Kyriazis, Maria E. Cimini, R. Badolia, S. Rajan, E. Gao, N. Nikolaidis, P. Schulze, I. Goldberg, R. Kishore, V. Yang, T. Bannister, A. Bialkowska, C. Selzman, S. Drakos, Konstantinos Drosatos   +16 more
semanticscholar   +1 more source

Krüppel‐Like Factor 15/Interleukin 11 Axis‐Mediated Adventitial Remodeling Depends on Extracellular Signal‐Regulated Kinases 1 and 2 Activation in Angiotensin II–Induced Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Adventitial remodeling is a pathological hallmark of hypertension that results in target organ damage. Activated adventitial fibroblasts have emerged as critical regulators in this process, but the precise mechanism remains unclear.
Yue‐Tong Guo, Yuan‐Yuan Lu, Xiao Lu, Shun He, Shi‐Jin Li, Shuai Shao, Han‐Dan Zhou, Rui‐Qi Wang, Xiao‐Dong Li, Ping‐Jin Gao   +9 more
doaj   +1 more source

A requirement for Krüppel Like Factor‐4 in the maintenance of endothelial cell quiescence

Frontiers in Cell and Developmental Biology, 2022
Rationale and Goal: Endothelial cells (ECs) are quiescent and critical for maintaining homeostatic functions of the mature vascular system, while disruption of quiescence is at the heart of endothelial to mesenchymal transition (EndMT) and tumor ...
Victoria Mastej, Cassondra Axen, Anita Wary, Richard D. Minshall, Kishore K. Wary   +4 more
doaj   +1 more source

Krüppel-like factor (KLF)5: An emerging foe of cardiovascular health.

Journal of Molecular and Cellular Cardiology, 2021
Krüppel-like factors (KLFs) are DNA-binding transcriptional factors, which regulate various pathways that pertain to development, metabolism and other cellular mechanisms.
D. Palioura, A. Lazou, Konstantinos Drosatos   +2 more
semanticscholar   +1 more source

Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 Regulates fkbp5 and Metabolism

Frontiers in Cell and Developmental Biology, 2021
Krüppel-like factor 9 (Klf9) is a feedforward regulator of glucocorticoid receptor (GR) signaling. Here we show that in zebrafish klf9 is expressed with GR-dependent oscillatory dynamics in synchrony with fkbp5, a GR target that encodes a negative ...
Ian M. Gans, Ian M. Gans, Janelle Grendler, Remy Babich, Nishad Jayasundara, James A. Coffman, James A. Coffman   +6 more
doaj   +1 more source

Roles of Krüppel‐like factor 5 in kidney disease

Journal of Cellular and Molecular Medicine, 2021
Transcription factor Krüppel‐like factor 5 (KLF5) is a member of the Krüppel‐like factors’ (KLFs) family. KLF5 regulates a number of cellular functions, such as apoptosis, proliferation and differentiation.
Jia Li, Liang Liu, Wenqian Zhou, L. Cai, Zhong-Gao Xu, M. Rane   +5 more
semanticscholar   +1 more source

Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]

, 2013
Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op, De Wever, Olivier, Lardon, Filip, LIMAME, RIDHA, Pauwels, Patrick   +4 more
core   +3 more sources