Results 21 to 30 of about 169,530 (195)

Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis

Nature Communications, 2018
While being known as a transcription factor, Kruppel-like factor 4 (Klf4) may have other molecular functions. This study shows that Klf4 in neural progenitor cells regulate neurogenesis and self-renewal by interacting with RNA-binding protein Staufen1 ...
Byoung-San Moon, Jinlun Bai, Mingyang Cai, Chunming Liu, Jiandang Shi, Wange Lu   +5 more
doaj   +2 more sources

Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis. [PDF]

Burns Trauma, 2023
Background Non-healing wounds are an intractable problem of major clinical relevance. Evidence has shown that dermal papilla cells (DPCs) may regulate the wound-healing process by secreting extracellular vesicles (EVs).
Wang Y, Shen K, Sun Y, Cao P, Zhang J, Zhang W, Liu Y, Zhang H, Chen Y, Li S, Xu C, Han C, Qiao Y, Zhang Q, Wang B, Luo L, Yang Y, Guan H.   +17 more
europepmc   +2 more sources

Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Krüppel-Like Factor 4). [PDF]

Arterioscler Thromb Vasc Biol, 2021
Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to contract and relax, thus modulating blood flow. They also play a crucial role
Yap C, Mieremet A, de Vries CJM, Micha D, de Waard V.   +4 more
europepmc   +2 more sources

Author Correction: MircoRNA-145 promotes activation of hepatic stellate cells via targeting krüppel-like factor 4 [PDF]

Scientific Reports, 2023
Ruoting Men, Maoyao Wen, Mingyue Zhao, Xuelian Dan, Zongze Yang, Wenchao Wu, Maggie Haitian Wang, Xiaojing Liu, Li Yang   +8 more
doaj   +2 more sources

Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis. [PDF]

Ann Rheum Dis, 2022
Objectives Analysing expression patterns of Krüppel-like factor (KLF) transcription factors in normal and osteoarthritis (OA) human cartilage, and determining functions and mechanisms of KLF4 and KLF2 in joint homoeostasis and OA pathogenesis.
Kawata M, Teramura T, Ordoukhanian P, Head SR, Natarajan P, Sundaresan A, Olmer M, Asahara H, Lotz MK.   +8 more
europepmc   +2 more sources

<i>Fusobacterium nucleatum</i> Promotes the Growth and Metastasis of Colorectal Cancer by Activating E-Cadherin/Krüppel-Like Factor 4/Integrin α5 Signaling in a Calcium-Dependent Manner. [PDF]

MedComm (2020)
Gut microbiota and integrins are known to contribute to colorectal cancer (CRC), but whether they interact has been unclear. Here, we provided evidence that Fusobacterium nucleatum upregulated integrin α5 (ITGA5) in CRC in both human patients and murine ...
Yan X, Qu X, Wang J, Lu L, Wu W, Mao J, Li D, Wang Y, Wei Q, Liu J.   +9 more
europepmc   +2 more sources

Therapeutic Targeting of Krüppel-Like Factor 4 and Its Pharmacological Potential in Parkinson's Disease: a Comprehensive Review. [PDF]

Mol Neurobiol, 2023
Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, is found in different human tissues and shows diverse regulatory activities in a cell-dependent manner.
Zamanian MY, Golmohammadi M, Amin RS, Bustani GS, Romero-Parra RM, Zabibah RS, Oz T, Jalil AT, Soltani A, Kujawska M.   +9 more
europepmc   +2 more sources

Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial-mesenchymal transition. [PDF]

Ren Fail
Acute kidney injury (AKI) can progress to renal fibrosis and chronic kidney disease (CKD), which reduces quality of life and increases the economic burden on patients.
Zhao J, Wang X, Wu Y, Zhao C.
europepmc   +2 more sources

Decreased Krüppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells. [PDF]

BMC Mol Cell Biol, 2022
Poor decidualization and abnormal autophagy conditions in the endometria of adenomyosis patients have been reported previously. However, the specific regulatory mechanism of decidualization in adenomyosis and its relationship with autophagy levels have ...
Mei J, Sheng X, Yan Y, Cai X, Zhang C, Tian J, Zhang M, Zhou J, Shan H, Huang C.   +9 more
europepmc   +2 more sources

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner. [PDF]

Mol Cell Proteomics, 2021
Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the third cause of cancer mortality. PCa initiation and growth are driven by the androgen receptor (AR). The AR is activated by androgens such as testosterone and controls prostatic
Vélot L, Lessard F, Bérubé-Simard FA, Tav C, Neveu B, Teyssier V, Boudaoud I, Dionne U, Lavoie N, Bilodeau S, Pouliot F, Bisson N.   +11 more
europepmc   +2 more sources