Krüppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA-Mediated, p53-Independent Apoptosis in Triple-Negative Breast Cancer Cells. [PDF]
Genes (Basel), 2021 Inducing apoptosis is an effective treatment for cancer. Conventional cytotoxic anticancer agents induce apoptosis primarily through activation of tumor suppressor p53 by causing DNA damage and the resulting regulation of B-cell leukemia/lymphoma-2 (BCL ...
Nakajima W +4 more
europepmc +2 more sources
Intestinal epithelial Krüppel-like factor 4 alleviates endotoxemia and atherosclerosis through improving NF-κB/miR-34a-mediated intestinal permeability. [PDF]
Acta Pharmacol SinNie HZ +7 more
europepmc +2 more sources
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types. [PDF]
Int J Mol Sci, 2020 Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays many roles in cancer.
Taracha-Wisniewska A +3 more
europepmc +2 more sources
Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease [PDF]
, 2016 BACKGROUND: Small airway remodeling is an important cause of the airflow limitation in chronic obstructive pulmonary disease (COPD). A large population of patients with COPD also have pulmonary hypertension.
Abe, K +14 more
core +4 more sources
Translational Oncology, 2022 Background: Non-small cell lung cancer (NSCLC) remains an aggresive tumor with poor survival rates. Krüppel-like factor 4 (KLF4) is known to be involved in progression of NSCLC; however, the detailed mechanism by which KLF4 regulates the progression of ...
Di-Di Luo, Feng Zhao
doaj +1 more source
Endothelial-specific loss of Krüppel-Like Factor 4 triggers complement-mediated endothelial injury.
Kidney International, 2022 Thrombotic microangiopathy (TMA) in the kidney represents the most severe manifestation of kidney microvascular endothelial injury. Despite the source of the inciting event, the diverse clinical forms of kidney TMA share dysregulation of endothelial cell
Chelsea C. Estrada +9 more
semanticscholar +1 more source
Acta Biochimica Polonica, 2022 OBJECTIVES Human bone marrow mesenchymal stem cells (BMSCs) have multi-lineage differentiation potential and have been widely researched in regenerative medicine.
Z. Fei +4 more
semanticscholar +1 more source
Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. [PDF]
PLoS ONE, 2012 Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine.
Tianxin Yu +7 more
doaj +1 more source
Gynecological Endocrinology, 2022 Objectives This study aims to determine serum levels of human Krüppel-like factors (KLFs), sP-selectin and sE-selectin and establish correlations between them in patients with gestational diabetes mellitus (GDM).Methods Twenty-six GDM patients aged ...
Hongmei Zhang# +2 more
doaj +1 more source