Tumor Biology, 2017 Purpose: The aim of this study was to explore the associations of Kruppel-like factor 4 expression with sensitivity to radiation therapy in locally advanced cervical squamous cell carcinoma patients.
Hai-Xia Liu +10 more
doaj +1 more source
Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation
Journal of Neuroinflammation, 2012 Background Neuroinflammation occurs as a result of microglial activation in response to invading micro-organisms or other inflammatory stimuli within the central nervous system.
Kaushik Deepak +4 more
doaj +1 more source
Key signalling nodes in mammary gland development and cancer: the snail1-twist1 conspiracy in malignant breast cancer progression [PDF]
, 2010 Breast cancer is the most common cancer among women, and despite significant advances in diagnosing and treating it, metastatic spread of cancer cells results in a high mortality rate. Epithelial-to-mesenchymal transition (EMT) is an embryonic program in
Foubert, Ellen +2 more
core +2 more sources
Krüppel-like factor 4 transcriptionally regulates TGF-β1 and contributes to cardiac myofibroblast differentiation. [PDF]
PLoS ONE, 2013 Angiotensin II (Ang II) plays a major role in the pathogenesis of cardiac fibrosis in hypertension. It is known that Ang II induces TGF-β1 expression.
Yi Zhang +5 more
doaj +1 more source
Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma
Neoplasia: An International Journal for Oncology Research, 2010 Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown. We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in medulloblastoma using high-resolution
Yukiko Nakahara +14 more
doaj +1 more source
コッカクケイ サイボウ ニ オケル テンシャ インシ Krüppel-Like Factor 4 ノ サヨウ カイセキ [PDF]
Material from: 'Fujikawa, J., Tanaka, M., Itoh, S., et al., Kruppel-like factor 4 expression in osteoblasts represses osteoblast-dependent osteoclast maturation, Cell and Tissue Research, published 2014, Springer ...
フジカワ, ジュンジ +1 more
core +1 more source
Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]
, 2019 BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda +5 more
core +5 more sources
Journal of Neuroinflammation, 2010 Background Activation of microglia, the resident macrophages of the central nervous system (CNS), is the hallmark of neuroinflammation in neurodegenerative diseases and other pathological conditions associated with CNS infection.
Das Sulagna +3 more
doaj +1 more source
An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death. [PDF]
, 2016 Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, which encodes the extracellular matrix protein fibrillin-1.
Bernard, William George +6 more
core +1 more source
A novel role of Krüppel-like factor 4 in Zhikong scallop Chlamys farreri during spermatogenesis. [PDF]
PLoS ONE, 2017 Krüppel-like factor 4 (KLF4) is a kind of zinc finger transcription factor, which is involved in terminal differentiation of epithelial cells and reprogramming of somatic cells to induced pluripotent stem (iPS) cells in mammals.
Dandan Yang +5 more
doaj +1 more source