Results 61 to 70 of about 169,530 (195)

The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo [PDF]

, 2012
The CACCC-box binding protein erythroid Kruppel-like factor (EKLF/KLF1) is a master regulator that directs the expression of many important erythroid genes.
Borg J, Coghill E, Eaton SA, Enomoto T, Feng WC, Hancock D, Henderson NC, Hodge D, Nuez B, Paulson RF, Pearson R, Pearson RC, Perkins AC, Sears DA, Shi Y, Socolovsky M, Tallack MR, Tallack MR, Turner J, Turner J, Vu TT, Zhang J, Zhang W   +22 more
core   +1 more source

Upregulation of the microRNA rno-miR-146b-5p may be involved in the development of intestinal injury through inhibition of Kruppel-like factor 4 in intestinal sepsis

Bioengineered, 2020
Regulatory mechanisms of microRNAs (miRNAs) in the development of intestinal sepsis are unclear. This study investigated the role of rno-miR-146b-5p in sepsis-induced intestinal injury. A rat sepsis model was created using the cecal ligation and puncture
L. Tong, Chaoxi Tang, C. Cai, X. Guan
semanticscholar   +1 more source

Genregulatorische und funktionelle Analysen des differentiell exprimierten rolling pebbles Transkriptes rols6 zeigen, dass das Rols6 Protein für die vollständige Differenzierung der Malpighischen Gefäße in Drosophila melanogaster notwendig ist. [PDF]

, 2004
Die Kommunikation zwischen zwei Zellpopulationen, Zell-Migration und -Adhäsion sind in der Entwicklung der Malpighischen Gefäße (MpG) wie auch in der Muskelentwicklung von Drosophila melanogaster während der Myoblastenfusion essentielle biologische ...
Pütz, Michael, Renkawitz-Pohl, Renate (Prof. Dr.)   +1 more
core   +1 more source

Association of serum KLF5 and actinin-4 levels with prognosis of TACE treatment for hepatocellular carcinoma [PDF]

Jichu yixue yu linchuang
Objective To explore the relationship between serum Krüppel-like factor 5(KLF5) and actinin-4 with prognosis of hepatocellular carcinoma (HCC) treated with transcatheter arterial chemoembolization (TACE).
LI Shunle, LI Rong, TIAN Yaya, RAN Xiaoli, ZHAO Yanpei, XU Meng
doaj   +1 more source

Role of Klf4 in the Regulation of Apoptosis and Cell Cycle in Rat Granulosa Cells during the Periovulatory Period [PDF]

, 2019
In the ovary, the luteinizing hormone (LH) surge suppresses the proliferation and induces the luteinization of preovulatory granulosa cells (GCs), which is crucial for the survival of terminally-differentiated GCs.
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core   +1 more source

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

Advanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli, Andrea Pianetti, Elena Mancinelli, Anthea Villano, Matteo Vailati, Paola Lagonegro, Miryam Criado‐Gonzalez, Montserrat Climent, Hansel Comas‐Rojas, Leonardo Elia, Francesco Moccia, Gabriele Tullii, Maria Rosa Antognazza   +12 more
wiley   +1 more source

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML [PDF]

, 2012
A unique characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSCs and potentially also in leukemia stem cells. Recently,
Armstrong, Scott A., Arreba-Tutusaus, Patricia, Bullinger, Lars, Döhner, Konstanze, Fischer, Thomas, Gaebel, Julia, Heidel, Florian H., Hirt, Carsten, Lane, Steven W., Niederwieser, Dietger, Vasioukhin, Valera, Wang, Zhu   +11 more
core   +3 more sources

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Bioinformatic Prediction of Novel microRNAs Encoded in Krüppel-like Factor 4 Gene [PDF]

Journal of Genetic Resources
MicroRNAs are small non-coding RNAs that can regulate gene expression that affects various cellular processes. Krüppel-like factor 4 (KLF4) is a transcription factor that has different regulatory functions, and it plays a role in various cellular ...
Mina Zahiri, Maryam Hassanlou, Amir-Reza Javanmard, Nooshin Bijari   +3 more
doaj   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source