Results 71 to 80 of about 169,530 (195)

Krüppel‐like factor 4 induces apoptosis and inhibits tumorigenic progression in SK‐BR‐3 breast cancer cells

FEBS Open Bio, 2015
Krüppel‐like factor 4 (KLF4) functions as either a tumor suppressor or an oncogene in different tissues by regulating the expression of various genes.
Bing Wang, Ming-zhi Zhao, Nai-peng Cui, Dan-dan Lin, An-yi Zhang, Yan Qin, Cai-yun Liu, Wei-tao Yan, Jian-hong Shi, Bao-ping Chen   +9 more
doaj   +1 more source

Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0 [PDF]

, 2011
Background The rat hybridoma cell line YB2/0 appears a good candidate for the large-scale production of low fucose recombinant mAbs due to its lower expression of fut8 gene than other commonly used rodent cell lines.
Béatrice Teylaert, Edwige Meurice, Marie Bobowski, Anne Harduin-Lepers, Christine Gaucher, Alexandre Fontayne, Sylvie Jorieux, Philippe Delannoy   +7 more
core   +2 more sources

Krüppel‐like factor 4 regulates stemness and mesenchymal properties of colorectal cancer stem cells through the TGF‐β1/Smad/snail pathway

Journal of Cellular and Molecular Medicine, 2019
Krüppel‐like factor 4 (KLF4) was closely associated with epithelial‐mesenchymal transition and stemness in colorectal cancer stem cells (CSCs)‐enriched spheroid cells. Nonetheless, the underlying molecular mechanism is unclear.
Zhengwei Leng, Yong Li, Guojun Zhou, X. Lv, W. Ai, Jian-shui Li, Lingmi Hou   +6 more
semanticscholar   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Single‐cell sequencing reveals potential novel insights into appendage‐patterning and joint‐development in a spider

Developmental Dynamics, EarlyView.
Abstract Background Jointed appendages represent one of the key innovations of arthropods, and thus understanding the development and evolution of these structures is important for the understanding of the evolutionary success of Arthropoda. In this paper, we analyze a cell cluster that was identified in a previous single‐cell sequencing (SCS ...
Brenda I. Medina‐Jiménez, Graham E. Budd, Ralf Janssen   +2 more
wiley   +1 more source

Control of germ-band retraction in Drosophila by the zinc-finger protein HINDSIGHT [PDF]

, 1997
Drosophila embryos lacking hindsight gene function have a normal body plan and undergo normal germ-band extension. However, they fail to retract their germ bands.
Lamka, Michele L., Lipshitz, Howard D., Yip, M. L. Richard   +2 more
core  

PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury. [PDF]

, 2020
Organ ischemia reperfusion injury (IRI), associated with acute hepatocyte death, remains an unresolved problem in clinical orthotopic liver transplantation (OLT).
Busuttil, Ronald W, Gao, Feng, Ji, Haofeng, Kupiec-Weglinski, Jerzy W, Liu, Yuanxing, Shen, Xiu-da, Xue, Zhengze, Zhang, Cheng, Zhang, Yu, Zheng, Shusen   +9 more
core  

Identifizierung potentieller Zielgene des Transkriptionsfaktors Sp3 in vitro und in vivo [PDF]

, 2004
Der ubiquitär vorkommende Transkriptionsfaktor Sp3 (Specificity protein) sowie Sp1, Sp2 und Sp4 gehören zu einer Protein-Familie, die an Sequenzen auf der DNA wie die GC-Box oder die GT-Box binden.
Schmidt, Gabriele, Suske, Guntram (Prof. Dr.)   +1 more
core   +1 more source

miR-7-5p regulates the proliferation and migration of colorectal cancer cells by negatively regulating the expression of Krüppel-like factor 4

Oncology Letters, 2019
Previous studies have demonstrated that microRNA-7-5p (miR-7-5p) functions as a tumor suppressor in certain types of human cancer. However, the role of miR-7-5p in colorectal cancer (CRC) remains to be investigated.
Mingjun Dong, Yangyang Xie, Yidong Xu
semanticscholar   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source