Results 91 to 100 of about 169,530 (195)

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Loss of the Krüppel-like factor 4 tumor suppressor is associated with epithelial-mesenchymal transition in colorectal cancer. [PDF]

J Cancer Metastasis Treat, 2019
Colorectal cancer (CRC) is the third leading cancer-related cause of death due to its propensity to metastasize. Epithelial-mesenchymal transition (EMT) is a multistep process important for invasion and metastasis of CRC.
Agbo KC, Huang JZ, Ghaleb AM, Williams JL, Shroyer KR, Bialkowska AB, Yang VW.   +6 more
europepmc   +2 more sources

Secretome analysis of breast cancer-associated adipose tissue to identify paracrine regulators of breast cancer growth [PDF]

, 2017
Adipose tissue secretes a plethora of adipokines as evidenced by characterization of subcutaneous and visceral adipose tissue secretomes. However, adipose tissue composition and secretion pattern is depot and disease dependent, influencing the adipose ...
Bracke, Marc, Braems, Geert, Cocquyt, Veronique, De Wever, Olivier, Denys, Hannelore, Hendrix, An, Lapeire, Lore, Lecoutere, Evelyne, Maynard, Dawn, Müller, Cathérine, Van Bockstal, Mieke, Van den Broecke, Rudy, Vandesompele, Jo   +12 more
core   +2 more sources

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Occurrence and Significance of the Nuclear Transcription Factor Krüppel-Like Factor 4 (KLF4) in the Vessel Wall

Acta Medica, 2009
Practically all mammalian cells including human can switch, according to micro- or macroenvironmental conditions, from states of cellular quiescence to inflammatory activation and vice versa.
Pavel Kuneš, Zdeňka Holubcová, Jan Krejsek   +2 more
doaj   +1 more source

Polycystic Ovary Syndrome in Overweight and Normal Weight Women: The Relationships with Inflammatory Markers

Bagcilar Medical Bulletin, 2020
Objective:The etiology and pathophysiology of Polycystic Ovary syndrome (PCOS) are not yet clearly explained as the disease has a heterogeneous clinical presentation. Several cytokines produced by the ovary and other tissues contribute to the maintenance
Tolga Atakul, Özgür Deniz Turan, Çiğdem Yenisey   +2 more
doaj   +1 more source

Downregulation of KLF8 expression by shRNA induces inhibition of cell proliferation in CAL27 human oral cancer cells [PDF]

, 2013
Objectives: KLF8 is a member of KLF transcription factors which play an important tolr in oncogenesis. It is barely expressed in normal human epithelial cells but highly overexpressed in several types of human cancer cell lines.
Bin, Zhang, Chun-Peng, Xia, Dao-Ying, Yuan, Ke-Yi, Li, Li-Cheng, Jiang, Shu-Wei, Liu, Wei-Feng, Zhang, Xian-Bin, Liu   +7 more
core   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Doxycycline inducible Krüppel-like factor 4 lentiviral vector mediates mesenchymal to epithelial transition in ovarian cancer cells. [PDF]

PLoS ONE, 2014
Ovarian cancer presents therapeutic challenges due to its typically late detection, aggressive metastasis, and therapeutic resistance. The transcription factor Krüppel-like factor 4 (KLF4) has been implicated in human cancers as a tumor suppressor or ...
Zixuan Chen, Yinan Wang, Wen Liu, Guannan Zhao, Suechin Lee, Andrea Balogh, Yanan Zou, Yuqi Guo, Zhan Zhang, Weiwang Gu, Chengyao Li, Gabor Tigyi, Junming Yue   +12 more
doaj   +1 more source

Global gene expression profiling of brown to white adipose tissue transformation in sheep reveals novel transcriptional components linked to adipose remodeling [PDF]

, 2015
BACKGROUND: Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT).
Basse, Astrid L., Dixen, Karen, Gupta, Ramneek, Hansen, Jacob B., Kristiansen, Karsten, Quistorff, Bjorn, Qvortrup, Klaus, Tygesen, Malin P., Wang, Jun, Yadav, Rachita   +9 more
core   +3 more sources