Results 101 to 110 of about 169,530 (195)

Elevated CO2 and Temperature Alter Grass Pollen's Ability to Modify Transcriptome and Function of the Nasal Epithelium

Allergy, EarlyView.
We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen, Tanja Turunen, Maria‐Viola Martikainen, Miisa Kankaanpää, Marjo Malinen, Marjut Roponen   +5 more
wiley   +1 more source

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, EarlyView.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

MircoRNA-145 promotes activation of hepatic stellate cells via targeting krüppel-like factor 4

Scientific Reports, 2017
Krüppel-like Factor 4 (KLF4), a target gene of miR-145, can negatively regulate lung fibrosis. However, the potential role of KLF4 and miR-145 in hepatic stellate cells (HSCs) activation or in hepatic fibrosis keeps unclear.
Ruoting Men, Maoyao Wen, Mingyue Zhao, Xuelian Dan, Zongze Yang, Wenchao Wu, Maggie Haitian Wang, Xiaojing Liu, Li Yang   +8 more
doaj   +1 more source

Differential expression of Krüppel-like factor 4 and 5 in oral carcinomas and involvement in the epithelial-mesenchymal transition [PDF]

, 2014
日本歯科大学201
柴田 征紀
core  

Kruppel-like factor 6 regulates transforming growth factor-beta gene expression during human respiratory syncytial virus infection [PDF]

, 2011
Background Human respiratory syncytial virus (RSV) infection is associated with airway remodeling and subsequent asthma development. Transforming growth factor-beta (TGF) plays a crucial role in asthma development.
Victoria Mgbemena, Jesus A Segovia, Te-Hung Chang, Santanu Bose   +3 more
core   +1 more source

Regulation of Krüppel-Like Factor 4 (KLF4) expression through the transcription factor Yin-Yang 1 (YY1) in non-Hodgkin B-cell lymphoma

OncoTarget, 2019
Krüppel-Like Factor 4 (KLF4) is a member of the KLF transcription factor family, and evidence suggests that KLF4 is either an oncogene or a tumor suppressor.
M. Morales-Martínez, Alberto Valencia-Hipólito, Gabriel G. Vega, N. Neri, M. Nambo, I. Alvarado, I. Cuadra, M. A. Durán-Padilla, O. Martínez-Maza, S. Huerta-Yepez, M. Vega   +10 more
semanticscholar   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Krüppel-like Factor 4 Inhibits Tumorigenic Progression and Metastasis in a Mouse Model of Breast Cancer

Neoplasia: An International Journal for Oncology Research, 2011
Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that functions as an oncogene or tumor suppressor in a highly tissue-specific cell-dependent manner. However, its precise role in breast cancer and metastasis remains unclear.
Jennifer L Yori, Darcie D Seachrist, Emhonta Johnson, Kristen L Lozada, Fadi W Abdul-Karim, Lewis A Chodosh, William P Schiemann, Ruth A Keri   +7 more
doaj   +1 more source

Untersuchungen zur Rolle des Transkriptionsfaktors "Krueppel-like factor 4" in der Sertoli-Zelle der Maus [PDF]

, 2006
Der Zinkfinger-Transkriptionsfaktor "Krueppel-like factor 4" (Klf4) wird in Epithelzellen vieler Gewebe, wie z.B. des Darms, des Magens und der Haut stark exprimiert.
Godmann, Maren, Renkawitz-Pohl, Renate (Prof. Dr.)   +1 more
core   +1 more source

Interplay among p21Waf1/Cip1, MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-CreER reserve intestinal stem cells after gamma radiation-induced injury

Scientific Reports, 2020
Gamma radiation is a commonly used adjuvant treatment for abdominally localized cancer. Since its therapeutic potential is limited due to gastrointestinal (GI) syndrome, elucidation of the regenerative response following radiation-induced gut injury is ...
E. Orzechowska, T. Katano, A. Bialkowska, V. Yang   +3 more
semanticscholar   +1 more source