Results 101 to 110 of about 38,499 (231)

Double the Double: Revisiting BCL11B's Multimerization

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 7, Page 1205-1211, July 2025.
ABSTRACT The transcription factor B Cell Lymphoma/Leukemia 11B (BCL11B) exerts a bi‐directional function in cancer, with its role as an emerging therapeutic target in cancer treatment being particularly intriguing. BCL11B knockouts in cultured T cells revealed the acquisition of properties characteristic of natural killer cells, hinting at its ...
Anne Susemihl, Norman Geist, Piotr Grabarczyk, Christian A. Schmidt, Mihaela Delcea, Lukas Schulig   +5 more
wiley   +1 more source

Multimodal transcriptional control of pattern formation in embryonic development [PDF]

, 2020
Predicting how interactions between transcription factors and regulatory DNA sequence dictate rates of transcription and, ultimately, drive developmental outcomes remains an open challenge in physical biology.
Galstyan, Vahe, Garcia, Hernan G., Lammers, Nicholas C., Medin, Sean A., Reimer, Armando, Wiggins, Chris H.   +5 more
core   +1 more source

Transcriptional profiling of fetal hypothalamic TRH neurons [PDF]

, 2011
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Castillo-Ramirez, Santiago, Charli, Jean-Louis, Guerra-Crespo, Magdalena, Gutierrez-Rios, Rosa M, Janga, Sarath Chandra, Joseph-Bravo, Patricia, Perez-Martinez, Leonor, Perez-Monter, Carlos   +7 more
core   +4 more sources

C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum-Infected Mice

Journal of Immunology Research, 2019
CCAAT/enhancer-binding homologous protein (CHOP), a transcriptional regulator induced by endoplasmic reticulum stress (ER stress) is a pivotal factor in the ER stress-mediated apoptosis pathway.
Mengyun Duan, Yuan Yang, Shuang Peng, Xiaoqin Liu, Jixin Zhong, Yurong Guo, Min Lu, Hao Nie, Boxu Ren, Xiangzhi Zhang, Lian Liu   +10 more
doaj   +1 more source

Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential

Frontiers in Cardiovascular Medicine, 2018
The role of inflammation in vascular disease is well recognized, involving dysregulation of both circulating immune cells as well as the cells of the vessel wall itself.
David R. Sweet, David R. Sweet, Liyan Fan, Liyan Fan, Paishiun N. Hsieh, Paishiun N. Hsieh, Mukesh K. Jain   +6 more
doaj   +1 more source

A Novel Function of NaV Channel β3 Subunit in Endothelial Cell Alignment Through Autophagy Modulation

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
NaVβ3 expression is increased by laminar shear stress (LSS) through KLF4 induction (1). NaVβ3 is retained within the cell and interacts with mTOR protein and colocalizes partially with LAMP1 and LC3B, lysosome and autophagosome markers, respectively (2). Since SiRNA SCN3B induces the decrease of LC3B expression and cell alignment in response to LSS (3),
Léa Réthoré, Anne‐Laure Guihot, Linda Grimaud, Coralyne Proux, Benjamin Barré, François Guillonneau, Catherine Guette, Alice Boissard, Cécile Henry, Jérôme Cayon, Rodolphe Perrot, Daniel Henrion, Christian Legros, Claire Legendre   +13 more
wiley   +1 more source

The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling [PDF]

, 2016
Aims/hypothesis: Pw1 or paternally-expressed gene 3 (Peg3) encodes a zinc finger transcription factor that is widely expressed during mouse embryonic development and later restricted to multiple somatic stem cell lineages in the adult.
Besson, Vanessa, Bonfanti, Paola, Heimberg, Harry, Heremans, Yves, Leuckx, Gunter, Marazzi, Giovanna, Sassoon, David, Sojoodi, Mozhdeh, Staels, Willem, Stradiot, Leslie, Tanaka, Karo, Van de Casteele, Mark   +11 more
core   +3 more sources

The Role of KLF4 in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2018
Krüppel-like factor 4 (KLF4), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions.
Ziqian Cheng, Xiaohan Zou, Yang Jin, Shuohui Gao, Jiayin Lv, Bingjin Li, Ranji Cui   +6 more
doaj   +1 more source

KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through Regulation of Wnt/β‐Catenin Signaling Pathway

Advanced Science, Volume 12, Issue 21, June 5, 2025.
In KLF1‐on (neonatal and Klf1 overexpression hearts) models, KLF1 regulates Wnt/β‐catenin signaling pathway and the expression of cell proliferation‐related genes via transcriptional and epigenetic mechanisms, which induces cardiomyocyte proliferation and cardiac regeneration in mice after myocardial infarction.
Yanglin Hao, Xi Zhang, Shuan Ran, Yuan Li, Weicong Ye, Song Wang, Xiaohan Li, Zilong Luo, Jiulu Zhao, Junjie Zong, Kexiao Zheng, Ran Li, Han Zhang, Longyong Lai, Pinyan Huang, Zifeng Zou, Wang Zhan, Zhang Yue, Jie Wu, Jiahong Xia   +19 more
wiley   +1 more source

KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS [PDF]

, 2017
Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs regulate axon growth in CNS neurons including retinal ganglion cells (RGCs). Here,
Apara, Akintomide, Ashouri, Masoumeh, Blackmore, Murray G., Brown, Dale P., Jr., Fernandes, Kimberly A., Galvao, Joana, Goldberg, Jeffrey L., Huang, Abigail, Iwao, Keiichiro, Kunzevitzky, Noelia J., Libby, Richard T., Moore, Darcie L., Nguyen, Tu, Shaw, Peter S., Trillo, Allison, Wang, Yan, Zhang, Ziong   +16 more
core   +2 more sources