Results 11 to 20 of about 30,078 (173)

Krüppel-like factor 4 control of immune cell function [PDF]

Frontiers in Immunology
Krüppel-like factor 4 (KLF4) belongs to a family of transcription factors that contain conserved zinc finger DNA binding domains, including specificity proteins (SPs) and Krüppel-like factors (KLFs).
Tapatee Das, Elaine Wang, Yitian Xu, Harrison Yang, Xudong Liao, Mukesh K. Jain, Mukesh K. Jain   +6 more
doaj   +2 more sources

Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment [PDF]

Cancer Medicine
Objective Krüppel‐like factor 4 (KLF4) is a zinc finger transcription factor that plays context‐dependent roles in cancer. It functions as either a tumor suppressor or an oncogene depending on tumor type and cellular context.
Min Tang, Binle Tian, Jingyi Zhou, Di Ma, Rongze Sun, Qi Li   +5 more
doaj   +2 more sources

Gene expression profiling of KLF4 and KLF5 in visceral adipose tissue of obese women: insights into adipogenic and metabolic regulation [PDF]

Lipids in Health and Disease
Background As global obesity rates rise, women are disproportionately affected, placing them at elevated risk for both metabolic dysfunction and cardiovascular complications.
Dalya Jamal Muhi, Maher Mohammed Murad, Ghodratollah Panahi, Hossein Zabihi-Mahmoudabadi, Solaleh Emamgholipour, Azin Nowrouzi   +5 more
doaj   +2 more sources

Krüppel-like factors in mitochondrial quality control [PDF]

Frontiers in Physiology
Krüppel-like factors (KLFs) are a group of transcription factors characterized by conserved zinc finger domains in the C-terminus, which are critically involved in basic cellular processes, including growth, differentiation, apoptosis, and angiogenesis ...
M. Y. Zhang, H. Zhang, Y. M. Yao, D. W. Yang   +3 more
doaj   +2 more sources

Krüppel-like Factors in the Gastrointestinal Tract [PDF]

Cells
The Krüppel-like factors (KLFs) are a family of transcriptional regulators that play crucial roles in regulating diverse cellular processes including development, proliferation, differentiation, metabolism, and carcinogenesis across various tissues. KLFs
Dharmendra Bhargava, Anchal Neha Bhargava, Jonathan P. Katz   +2 more
doaj   +2 more sources

Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors

Frontiers in Cell and Developmental Biology, 2021
Krüppel-like factor 6 (KLF6) is one of the most studied members of the specificity protein/Krüppel-like factor (SP/KLF) transcription factor family. It has a typical zinc finger structure and plays a pivotal role in regulating the biological processes of
Kang Hu, Qing-Kang Zheng, Rui-Jie Ma, Chao Ma, Zhi-Gang Sun, Nan Zhang   +5 more
doaj   +1 more source

Krüppel-like Factor 2 (KLF2) in Immune Cell Migration

Vaccines, 2021
Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell
Jens Wittner, Wolfgang Schuh
doaj   +1 more source

The self-organized learning of noisy environmental stimuli requires distinct phases of plasticity

Network Neuroscience, 2020
Along sensory pathways, representations of environmental stimuli become increasingly sparse and expanded. If additionally the feed-forward synaptic weights are structured according to the inherent organization of stimuli, the increase in sparseness and ...
Krüppel, Steffen, Tetzlaff, Christian
doaj   +1 more source

Krüppel‐Like Factor 15/Interleukin 11 Axis‐Mediated Adventitial Remodeling Depends on Extracellular Signal‐Regulated Kinases 1 and 2 Activation in Angiotensin II–Induced Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Adventitial remodeling is a pathological hallmark of hypertension that results in target organ damage. Activated adventitial fibroblasts have emerged as critical regulators in this process, but the precise mechanism remains unclear.
Yue‐Tong Guo, Yuan‐Yuan Lu, Xiao Lu, Shun He, Shi‐Jin Li, Shuai Shao, Han‐Dan Zhou, Rui‐Qi Wang, Xiao‐Dong Li, Ping‐Jin Gao   +9 more
doaj   +1 more source

Overexpression of Krüppel-Like Factor 4 Suppresses Migration and Invasion of Non-Small Cell Lung Cancer Through c-Jun-NH2-Terminal Kinase/Epithelial-Mesenchymal Transition Signaling Pathway

Frontiers in Pharmacology, 2020
Krüppel-like factor 4 (KLF4) is a transcription factor and plays a vital role in cancer initiation and development. However, the role of Krüppel-like factor 4 in the metastasis of non-small cell lung cancer (NSCLC) is not clear.
Yanping Wu, Lianjun Lin, Xiang Wang, Yong Li, Zhonghui Liu, Wei Ye, Weiming Huang, Gang Lin, Haibo Liu, Jixin Zhang, Ting Li, Beilei Zhao, Liping Lv, Jian Li, Nanping Wang, Xinmin Liu   +15 more
doaj   +1 more source