Results 21 to 30 of about 38,499 (231)
Induction of T-Cell Differentiation by KLF4 in T-Cell Acute Lymphoblastic Leukemia Cells Harboring Activating Mutation in NOTCH3. [PDF]
FASEB JKLF4‐induced T‐cell differentiation and apoptosis in TALL‐1 cells harboring an activating mutation in NOTCH3. KLF4 directly downregulated NOTCH3 expression by binding to its promoter, thereby promoting the differentiation of CD4/CD8 double‐positive cells into CD4 single‐positive cells, with the differentiated cells subsequently undergoing apoptosis ...
Noura M, Yasuda T, Kiyoi H, Hayakawa F.
europepmc +2 more sources
Technology in Cancer Research & Treatment, 2020 Cancer stem cells, a special subgroup of cancer cells, have self-renewal capabilities and multidirectional potential, which may be reprogrammed from the dedifferentiation of cancer cells, contributing to the failure of clinical treatments.
Mei Chen BSc +4 more
doaj +1 more source
JACC: Basic to Translational Science, 2018 Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms.
Nina M. Pollak, PhD +3 more
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Participation of Krüppel-like Factors in Atherogenesis
Metabolites, 2023 Atherosclerosis is an important problem in modern medicine, the keys to understanding many aspects of which are still not available to clinicians. Atherosclerosis develops as a result of a complex chain of events in which many cells of the vascular wall ...
Stanislav Kotlyarov, Anna Kotlyarova
doaj +1 more source
Mediators of Inflammation, 2016 Human fibroblast-like synoviocytes play a vital role in joint synovial inflammation in rheumatoid arthritis (RA). Proinflammatory cytokines induce fibroblast-like synoviocyte activation and dysfunction.
Xinjing Luo +6 more
doaj +1 more source
A mutation in mouse Krüppel-like factor 15 alters the gut microbiome and response to obesogenic diet
PLOS ONE, 2019 We identified a mouse strain, HLB444, carrying an N-ethyl-N-nitrosourea (ENU)-induced mutation in a highly conserved C2H2 zinc-finger DNA binding motif of the transcriptional regulator KLF15 that exhibits resistance to diet-induced obesity. Characterization of the HLB444 mutant model on high-fat and chow diets revealed a number of phenotypic ...
Karen L. Svenson +3 more
openaire +6 more sources
Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway. [PDF]
, 2017 Recent studies have linked branched-chain amino acid (BCAA) with numerous metabolic diseases. However, the molecular basis of BCAA's roles in metabolic regulation remains to be established.
Dong, Weibing +5 more
core +2 more sources
PLOS ONE, 2016 In human adult erythroid cells, lower than normal levels of Krüppel-like transcription factor 1 (KLF1) are generally associated with decreased adult β- and increased fetal γ-globin gene expression. KLF1 also regulates BCL11A, a known repressor of adult γ-globin expression.
Vinjamur, Divya +5 more
openaire +6 more sources
Re-utilization of a transcription factor
eLife, 2016 The temporal transcription factor Krüppel has a dual role in the development of neurons.
Filipe Pinto-Teixeira, Claude Desplan
doaj +1 more source
Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
Nature Communications, 2020 Immune cells are important regulators of adipose tissue function, including adaptive thermogenesis. Here the authors show that mice with Krüppel-like factor 3 (KLF3) deficiency in bone marrow-derived cells have increased adipose tissue beiging which may ...
Alexander J. Knights +13 more
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