Results 41 to 50 of about 30,078 (173)

In vivo activation of the human δ-globin gene: the therapeutic potential in β-thalassemic mice

Haematologica, 2014
β-thalassemia and sickle cell disease are widespread fatal genetic diseases. None of the existing clinical treatments provides a solution for all patients.
Maria F. Manchinu, Maria F. Marongiu, Daniela Poddie, Carla Casu, Veronica Latini, Michela Simbula, Renzo Galanello, Paolo Moi, Antonio Cao, Susanna Porcu, Maria S. Ristaldi   +10 more
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Krüppel Expression Levels Are Maintained through Compensatory Evolution of Shadow Enhancers

Cell Reports, 2015
Many developmental genes are controlled by shadow enhancers—pairs of enhancers that drive overlapping expression patterns. We hypothesized that compensatory evolution can maintain the total expression of a gene, while individual shadow enhancers diverge ...
Zeba Wunderlich, Meghan D.J. Bragdon, Ben J. Vincent, Jonathan A. White, Javier Estrada, Angela H. DePace   +5 more
doaj   +1 more source

The Involvement of Krüppel-like Factors in Cardiovascular Diseases

Life, 2023
Krüppel-like factors (KLFs) are a set of DNA-binding proteins belonging to a family of zinc-finger transcription factors, which have been associated with many biological processes related to the activation or repression of genes, inducing cell growth ...
Michelle G. Santoyo-Suarez, Jimena D. Mares-Montemayor, Gerardo R. Padilla-Rivas, Juan Luis Delgado-Gallegos, Adriana G. Quiroz-Reyes, Jorge A. Roacho-Perez, Diego F. Benitez-Chao, Lourdes Garza-Ocañas, Gilberto Arevalo-Martinez, Elsa N. Garza-Treviño, Jose Francisco Islas   +10 more
doaj   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

Roles of Krüppel Homolog 1 and Broad-Complex in the Development of Dendroctonus armandi (Coleoptera: Scolytinae)

Frontiers in Physiology, 2022
In insects, metamorphosis is controlled by juvenile hormone (JH) and 20-hydroxyecdysone (20E). Krüppel homolog 1 (Kr-h1), a key JH-early inducible gene, is responsible for the suppression of metamorphosis and the regulation of the Broad-Complex (Br-C ...
Ya-Ya Sun, Ya-Ya Sun, Dan-Yang Fu, Bin Liu, Lin-Jun Wang, Hui Chen   +5 more
doaj   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

In the I of the beholder: an attempt to capture the implicit self-concept regarding psychopathy

Frontiers in Psychology
This article explores the implicit self-concept pertaining to psychopathy. Two online studies showed inconsistent results, with Study 1 (n = 243) suggesting that psychopathy is linked to an implicit self-concept marked by low empathy and Study 2 (n = 230)
Jonas Krüppel, Dahlnym Yoon, Katharina Zerres, Franziska Brunner, Andreas Mokros   +4 more
doaj   +1 more source

Increased Complement 3 With Suppression of miR‐145 Induces the Synthetic Phenotype in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We previously reported that vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHRs) show the increased expression of complement 3 (C3) and the synthetic phenotype.
Lan Chen, Noboru Fukuda, Tomoyasu Otsuki, Sho Tanaka, Yoshihiro Nakamura, Hiroki Kobayashi, Taro Matsumoto, Masanori Abe   +7 more
doaj   +1 more source

KLF15 suppresses tumor growth and metastasis in Triple-Negative Breast Cancer by downregulating CCL2 and CCL7

Scientific Reports, 2022
Kruppel like factor 15 (KLF15), a transcriptional factor belonging to the Kruppel-like factor (KLF) family of genes, has recently been reported as a tumor suppressor gene in breast cancer.
Quist Kanyomse, Xin Le, Jun Tang, Fengsheng Dai, Youchaou Mobet, Chang Chen, Zhaobo Cheng, Chaoqun Deng, Yijiao Ning, Renjie Yu, Xiaohua Zeng, Tingxiu Xiang   +11 more
doaj   +1 more source