Results 41 to 50 of about 38,499 (231)
Role of Klf4 in the Regulation of Apoptosis and Cell Cycle in Rat Granulosa Cells during the Periovulatory Period [PDF]
, 2019 In the ovary, the luteinizing hormone (LH) surge suppresses the proliferation and induces the luteinization of preovulatory granulosa cells (GCs), which is crucial for the survival of terminally-differentiated GCs.
���������
core +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background We previously reported that vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHRs) show the increased expression of complement 3 (C3) and the synthetic phenotype.
Lan Chen +7 more
doaj +1 more source
Molecular function of Krüppel-like factor 7 in biology
Acta Biochimica et Biophysica Sinica, 2023 Krüppel-like factor 7 ( KLF7), also named ubiquitous KLF ( UKLF) based on its ubiquitous expression in adult human tissues, is a conserved gene in animals.
Mao Yi, Chen Yuechan, Zhang Zhiwei
doaj +1 more source
Bicoid gradient formation and function in the Drosophila pre-syncytial blastoderm
eLife, 2016 Bicoid (Bcd) protein distributes in a concentration gradient that organizes the anterior/posterior axis of the Drosophila embryo. It has been understood that bcd RNA is sequestered at the anterior pole during oogenesis, is not translated until ...
Zehra Ali-Murthy, Thomas B Kornberg
doaj +1 more source
A requirement for Krüppel Like Factor‐4 in the maintenance of endothelial cell quiescence
Frontiers in Cell and Developmental Biology, 2022 Rationale and Goal: Endothelial cells (ECs) are quiescent and critical for maintaining homeostatic functions of the mature vascular system, while disruption of quiescence is at the heart of endothelial to mesenchymal transition (EndMT) and tumor ...
Victoria Mastej +4 more
doaj +1 more source
Frontiers in Physiology, 2022 In insects, metamorphosis is controlled by juvenile hormone (JH) and 20-hydroxyecdysone (20E). Krüppel homolog 1 (Kr-h1), a key JH-early inducible gene, is responsible for the suppression of metamorphosis and the regulation of the Broad-Complex (Br-C ...
Ya-Ya Sun +5 more
doaj +1 more source
Advanced Science, EarlyView.XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue +15 more
wiley +1 more source
Krüppel Expression Levels Are Maintained through Compensatory Evolution of Shadow Enhancers
Cell Reports, 2015 Many developmental genes are controlled by shadow enhancers—pairs of enhancers that drive overlapping expression patterns. We hypothesized that compensatory evolution can maintain the total expression of a gene, while individual shadow enhancers diverge ...
Zeba Wunderlich +5 more
doaj +1 more source
Advanced Science, EarlyView.The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park +9 more
wiley +1 more source
Control of germ-band retraction in Drosophila by the zinc-finger protein HINDSIGHT [PDF]
, 1997 Drosophila embryos lacking hindsight gene function have a normal body plan and undergo normal germ-band extension. However, they fail to retract their germ bands.
Lamka, Michele L. +2 more
core