Results 81 to 90 of about 30,078 (173)
Krüppel -Like Factor 8 is a Stress-Responsive Transcription Factor that Regulates Expression of HuR
Cellular Physiology and Biochemistry, 2014 Background/Aims: HuR is an RNA-binding protein that regulates the post-transcriptional life of thousands of cellular mRNAs and promotes cell survival. HuR is expressed as two mRNA transcripts that are differentially regulated by cell stress.
Suman Govindaraju, Beth S. Lee
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MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Krüppel-like factor 9 [PDF]
, 2020 Xiaofang Yan +12 more
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Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima +9 more
wiley +1 more source
JCI Insight, 2020 Resident vascular adventitial SCA1+ progenitor (AdvSca1) cells are essential in vascular development and injury. However, the heterogeneity of AdvSca1 cells presents a unique challenge in understanding signaling pathways orchestrating their behavior in ...
Sizhao Lu +8 more
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Advanced Science, Volume 13, Issue 7, 3 February 2026.This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang +15 more
wiley +1 more source
Regulation of Corneal Epithelial Barrier Function by Krüppel-like Transcription Factor 4 [PDF]
, 2010 Sudha Swamynathan +3 more
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Glia, Volume 74, Issue 2, February 2026.CD38 deficiency influences brain NAD/NAM metabolism. Global CD38 deficiency drives changes in astrocyte mitochondrial, metabolic, senescence, and neurodegenerative‐related genes. CD38 deficiency alters glial reactivity and astrocyte bioenergetics. ABSTRACT CD38 is an ectoenzyme that converts NAD+ to NAM to help maintain bioenergetic homeostasis.
S. Basak +15 more
wiley +1 more source
Molecular regulatory mechanism of Krüppel-like factor 9 in tumor development
Zhongguo linchuang yanjiuKrüppel-like factor 9 (KLF9) is a transcription factor containing three Cys2His2 zinc finger structures with a wide range of biological functions, including regulation of embryonic development, cell proliferation, apoptosis, differentiation, metastasis ...
LIU Cunyu, KONG Xia, WANG Shiqi, HE Zhiwei
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The Krüppel-like factor 9 cistrome in mouse hippocampal neurons reveals predominant transcriptional repression via proximal promoter binding [PDF]
, 2017 Joseph R. Knoedler +2 more
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