Results 91 to 100 of about 130,425 (315)

Robinson and Chasen's 'Birds of the Malay Peninsula' The Birds of the Malay Peninsula a General Account of the Birds Inhabiting the Region from the Isthmus of Kra to Singapore with the Adjacent Islands Volume IV Frederick N. Chasen [PDF]

, 1939
Glover M. Allen
openalex   +1 more source

KRAS mutation as a predictor of insufficient trastuzumab efficacy and poor prognosis in HER2-positive advanced gastric cancer

, 2022
Keitaro Shimozaki, Eiji Shinozaki, Noriko Yamamoto, Yu Imamura, Hiroki Osumi, Izuma Nakayama, Takeru Wakatsuki, Akira Ooki, Daisuke Takahari, Mariko Ogura, Keisho Chin, Masayuki Watanabe, Kensei Yamaguchi   +12 more
openalex   +2 more sources

KRAS NM_004985.3:c.182A>G [PDF]

, 2020
National Cancer Institute
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Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

KRAS-mutated non-small cell lung cancer: new therapy strategies

Сибирский онкологический журнал
Lung cancer remains one of the most dangerous and most common cancers, requiring constant improvement of diagnostic and treatment methods. The genetic heterogeneity of lung cancer forces us to search for new therapeutic targets in an attempt to achieve ...
K. K. Laktionov, K. A. Sarantseva, L. A. Nelyubina, S. V. Gamayunov, E. A. Kolesnikova, M. G. Gordiev   +5 more
doaj   +1 more source

Izbira lokacije za postavitev geomagnetnega observatorija v Sloveniji : Site selection for a permanent geomagnetic observation station in Slovenia [PDF]

Geodetski Vestnik, 2010
Raziskave na področju geomagnetizma lahko označimo kot prve raziskave na področju geofizike. Opazovanje geomagnetnega polja je bistvenegapomena za razumevanje temeljnih postopkov v središču Zemlje, njeni skorji in bližnji okolici planeta Zemlja.
Dejan Paliska, Rudi Čop, Daša Fabjan, Samo Drobne   +3 more
doaj  

466 Combined inhibition of KRAS G12C and PD-1 boosts the therapeutic efficacy via conditioning of tumor microenvironment in pre-clinical humanized NSCLC mouse models [PDF]

, 2023
Ting Ni, Tongxin Huo, Yawen Zhang, Panpan Wang, Huacheng He, Jingjing Wang, Wenting Shi, Xiangnan Qiang, Qingyang Gu   +8 more
openalex   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source