Results 81 to 90 of about 151,900 (300)

Flywheel inertial actuator for velocity feedback control: parametric study

, 2016
This paper presents a new proof mass actuator for the implementation of decentralised velocity feedback control loops to reduce the flexural vibration of a thin plate structure at low audio frequencies.
KRAS, Aleksander Stefan, GARDONIO, Paolo
core   +1 more source

A KRAS gén mutáció analízise nem kissejtes tüdőrákban és colorectális carcinómában

, 2016
A daganatos megbetegedések és halálozások igen magas gyakorisága komoly népegészségügyi probléma világszerte, így hazánkban is. A legtöbb áldozatot követelő daganatféleségek közül diplomadolgozatom elkészítése során a nem kissejtes tüdőrák és ...
Gazdag, Annamária
core  

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers [PDF]

Science
How theKRASoncogene drives cancer growth remains poorly understood. Therefore, we established a systemwide portrait of KRAS- and extracellular signal–regulated kinase (ERK)–dependent gene transcription in KRAS-mutant cancer to delineate the molecular mechanisms of growth and of inhibitor resistance.
Jeffrey A, Klomp, Jennifer E, Klomp, Clint A, Stalnecker, Kirsten L, Bryant, A Cole, Edwards, Kristina, Drizyte-Miller, Priya S, Hibshman, J Nathaniel, Diehl, Ye S, Lee, Alexis J, Morales, Khalilah E, Taylor, Sen, Peng, Nhan L, Tran, Laura E, Herring, Alex W, Prevatte, Natalie K, Barker, Laura D, Hover, Jill, Hallin, Alexey, Sorokin, Preeti Marie, Kanikarla, Saikat, Chowdhury, Oluwadara, Coker, Hey Min, Lee, Craig M, Goodwin, Prson, Gautam, Peter, Olson, James G, Christensen, John P, Shen, Scott, Kopetz, Lee M, Graves, Kian-Huat, Lim, Andrea, Wang-Gillam, Krister, Wennerberg, Adrienne D, Cox, Channing J, Der   +34 more
openaire   +3 more sources

New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness. [PDF]

, 2019
In non-small cell lung cancer (NSCLC), the most frequent oncogenic mutation in western countries is KRAS, for which, however, there remains no clinically approved targeted therapies. Recent progress on high biological heterogeneity including diverse KRAS
Peng, Ren-Wang, Shun-Qing, Liang, Schmid, Ralph A., Yang, Haitang   +3 more
core   +2 more sources

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

GEOPARK KRAS [PDF]

, 2022
Knjiga z naslovom »Geopark Kras« je poseben izdelek, saj priča o uspešnem čezmejnem sodelovanju, katerega skupni rezultat bo rojstvo čezmejnega geoparka na matičnem Krasu. Knjigo smo pripravili v projektu GeoKarst, ki je sofinanciran v okviru Programa sodelovanja Interreg V-A Italija - Slovenija 2014–2020.
Bensi S., Novak M., Otoničar B., Calligaris C., Cucchi F., Zini L., Bonini L., Barone V., Škrjanec S., Piano C.   +9 more
openaire  

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer [PDF]

, 2012
BACKGROUND: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies.
Mjøs, Siv, Wik, Elisabeth, Werner, Henrica Maria Johanna, M B Raeder, E Wik, Salvesen, Helga Birgitte, H B Salvesen, E A Hoivik, Høivik, Erling Andre, L A Akslen, J Trovik, Øyan, Anne Margrete, Akslen, Lars A., F Holst, R Simon, C Krakstad, Kalland, Karl-Henning, K Petersen, Krakstad, Camilla, Trovik, Jone, Kusonmano, Kanthida, E Birkeland, K-H Kalland, S Mjøs, Birkeland, Even, Ræder, Maria B., Holst, Frederik, H M J Werner, K Kusonmano, Simon, Ronald, Petersen, Kjell, A M Øyan   +31 more
core   +1 more source

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source