Results 91 to 100 of about 151,900 (300)

Targeting RAS – will GPR31 deliver us a new path forward?

Molecular & Cellular Oncology, 2017
Effective anti-rat sarcoma viral oncogene (RAS) therapies have remained the holy grail of cancer treatment. Mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) sustains tumorigenesis when linked to the plasma membrane (PM).
Nicole Fehrenbacher, Mark R. Philips
doaj   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Targeting mutant KRAS in human colon cancer cells through G-quadruplex ligands

, 2014
Teses de mestrado, Ciências Biofarmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014KRAS mutations occur in 35 to 45% of colon tumors, being an important target for cancer treatment, for which there are no targeted therapeutics available ...
Brito, Hugo Miguel de Sousa e
core  

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

CodeBreaK 200: Sotorasib (AMG510) Has Broken the KRAS G12C+ NSCLC Enigma Code

, 2023
Danielle Brazel,1 Jennifer Kim,1 Sai-Hong Ignatius Ou1,2 1University of California Irvine School of Medicine, Department of Internal Medicine, Division of Hematology-Oncology, Orange, CA, USA; 2Chao Family Comprehensive Cancer Center, Orange, CA ...
Brazel D, Kim J, Ou SI
core  

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Razumevanje okoljskih problemov na dinarskem krasu

Dela, 2003
Na glavnih območjih dinarskega krasa, na Krasu, jadranskih otokih in nizkih ravnikih ob dalmatinski obali prevladujeta tipično sredozemska raba tal, ki povzroča tudi spreminjanje površja, npr.
Jean Nicod
doaj   +1 more source

Internalising radioimmunoconjugates to target KRas cancer cells for simultaneous radio-ligand therapy and radiosensitisation [PDF]

The intracellular environment hosts many cancer-relevant proteins. Among them, Ras plays an important role and is frequently activated in cancers of unmet need, such as pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancers (NSCLC) and ...
Lourenço, João
core   +1 more source

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion [PDF]

, 2013
Background Prevalence of colorectal cancer (CRC) in the British Bangladeshi population (BAN) is low compared to British Caucasians (CAU). Genetic background may influence mutations and disease features.
Sengupta, N, Silver Andrew, Suraweera, Nirosha, Sieber, O, Sakthianandeswaren, A, Oliver Sieber, Suraweera, N, Yau, C, Jean-Baptiste Cazier, Yau, Christopher, Andrew Silver, Sieber Oliver, Lai, Cecilia, Yau Christopher, Guadalupe Polanco-Echeverry, Mouradov, Dmitri, Neel Sengupta, Sieber, Oliver, Suraweera Nirosha, Christopher Yau, Sengupta Neel, Dorudi, Sina, Feakins, R, Cazier, Jean-Baptiste, Feakins Roger, Gibbs, Peter, Sina Dorudi, Cecilia Lai, Cazier, J-B, Silver, Andrew, Peter Gibbs, Ahmed Shafi, Ahmed, Shafi, David Propper, Propper David, Thaha, M, Sakthianandeswaren Anuratha, Silver, A, Anil Ghosh, Roger Feakins, Polanco-Echeverry Guadalupe, Ghosh, Anil, Sengupta, Neel, Mohamed Thaha, Ghosh Anil, Mouradov Dmitri, Cazier Jean-Baptiste, Propper, David, Thaha Mohamed, Nirosha Suraweera, Cazier, Jean-Baptiste; id_orcid, Cazier, JB, Lai Cecilia, Dorudi, S, Anuratha Sakthianandeswaren, Ghosh, A, Shafi Ahmed, Mouradov, D, Ahmed, S, Gibbs Peter, Lai, C, Feakins, Roger, Polanco-Echeverry, G, Thaha, Mohamed, Dorudi Sina, Polanco-Echeverry, Guadalupe, Sakthianandeswaren, Anuratha, Gibbs, P, Propper, D, Dmitri Mouradov   +69 more
core   +1 more source