Results 71 to 80 of about 208,301 (303)

KRAS mutation testing of tumours in adults with metastatic colorectal cancer: a systematic review and cost-effectiveness analysis

Health Technology Assessment, 2014
Background: Bowel cancer is the third most common cancer in the UK. Most bowel cancers are initially treated with surgery, but around 17% spread to the liver. When this happens, sometimes the liver tumour can be treated surgically, or chemotherapy may be
Marie Westwood, Thea van Asselt, Bram Ramaekers, Penny Whiting, Manuela Joore, Nigel Armstrong, Caro Noake, Janine Ross, Johan Severens, Jos Kleijnen   +9 more
doaj   +1 more source

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]

, 2016
mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat, Califano, Joseph A, Callejas-Valera, Juan Luis, Cohen, Ezra E, Gutkind, J Silvio, Iglesias-Bartolomé, Ramiro, Lippman, Scott M, Luo, Ji, Molinolo, Alfredo A, Wang, Zhiyong, Yamaguchi, Kosuke   +10 more
core   +1 more source

KRAS inhibitors: going noncovalent

Molecular Oncology, 2022
KRASG12D is the most frequent KRAS mutation in human cancer with particularly high frequencies in pancreatic and colorectal cancer. Informed by the structure of the KRASG12C inhibitor adagrasib, Hallin et al. have now, through multiple rounds of structure‐based drug design, identified and validated a potent, selective, and noncovalent KRASG12D ...
Matthias Drosten, Mariano Barbacid
openaire   +5 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Comparison of the prevalence of KRAS-LCS6 polymorphism (rs61764370) within different tumour types (colorectal, breast, non-small cell lung cancer and brain tumours). A study of the Czech population

Biomedical Papers, 2015
Aims: A germline SNP (rs61764370) is located in a let-7 complementary site (LCS6) in the 3'UTR of KRAS oncogene, and it was found to alter the binding capability of the mature let-7 microRNA to the KRAS mRNA.
Magdalena Uvirova, Jarmila Simova, Barbora Kubovaª, Nina Dvorackova, Hana Tomaskova, Monika Sedivcova, Petr Dite   +6 more
doaj   +1 more source

Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles [PDF]

, 2019
Over 95% of pancreatic adenocarcinomas (PDACs), as well as a large fraction of other tumor types, such as colorectal adenocarcinoma, are driven by KRAS activation. However, no direct RAS inhibitors exist for cancer therapy.
Bi, Ye, Brooks, Candace, DeNardo, David G, Fields, Ryan C, Fleming, Timothy, Gillanders, William E, Goedegebuure, S Peter, Hawkins, William G, Krasnick, Bradley A, Pan, Hua, Sankpal, Narendra, Strand, Matthew S, Wetzel, Christopher, Wickline, Samuel A, Zhang, Xiuli   +14 more
core   +1 more source

The importance of circulating tumor products as „liquid biopsies” in colorectal cancer [PDF]

, 2018
Liquid biopsies represent an array of plasma analysis tests that are studied to evaluate and identify circulating tumor products, especially circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA).
Calborean, Veronica, Miscoci, Alina, Pirvu, Cristian D., Pădureanu, Vlad, Rogoveanu, Otilia C., Streba, Costin T., Vere, Cristin C.   +6 more
core   +4 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Molecular mechanisms of resistance and new therapeutic approaches in the treatment of colorectal cancer - a review of the literature

Journal of Education, Health and Sport
CRC occupies one of the leading positions among gastrointestinal malignancies and is a significant problem in Europe since it is the third most frequently diagnosed cancer. Recent developments in diagnostic techniques have led to higher chances of early
Maksymilian Janeczek, Julia Plewniok, Maria Partyka, Julia Wójcik, Karolina Kinga Kantor, Marcin Cholewa, Wiktoria Maria Szymańska, Karolina Jaglarz, Maciej Kuca, Kacper Wojciech Pamuła   +9 more
doaj   +1 more source

Lokalna vodooskrba na Krasu

Dela, 2010
Številni kraški izviri predstavljajo pomembne lokalne vire pitne vode, ki pokrivajo skoraj polovico državnih potreb. Prispevek obravnava način vodooskrbe v preteklosti ter današnje stanje, težave in izzive, s katerimi se soočamo.
Nataša Ravbar
doaj   +1 more source