Results 131 to 140 of about 116,020 (268)

The Case for the KRA [PDF]

, 2021
openaire   +1 more source

Variant‐Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs

International Journal of Cancer, EarlyView.
Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens, Jan‐Patrick Hetzel, Khaldoon Abdullah, Carolien Eggermont, Catharina Olsen, Marco Mernberger, Ken Maes, Jelle Vlaeminck, Rainer Claus, Dries Vanisterbecq, Frederik Hes, Martin Pichler, Philippe Giron, Oleg Timofeev, Maxim Noeparast   +14 more
wiley   +1 more source

Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population‐Based Study in Taiwan, 1994–2018

International Journal of Cancer, EarlyView.
Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai, Chih‐Yi Wu, Tsung‐I Hung, Hung‐Yi Chiou   +3 more
wiley   +1 more source

Frequent Detection of <i>KRAS</i>-G12C and <i>PIK3CA</i>-Q546K Mutations in MAP Tumors Highlights their Role in <i>MUTYH</i> Variants of Uncertain Significance Reclassification. [PDF]

Hum Mutat
Medeiros ABD, Kozak VN, Picanço-Albuquerque CG, Neto FGKV, Dos Santos GO, Junior SA, Casali-da-Rocha JC, Carraro DM, Torrezan GT.   +8 more
europepmc   +1 more source

Closing the Loop in Precision Oncology: A Digital Twin‐Driven Paradigm for Dynamic Decision‐Making

iMetaMed, EarlyView.
This review introduces the Closed‐Loop Intelligent Oncology System (CIOS), a five‐layer framework integrating digital twins and AI to enable adaptive, data‐driven cancer treatment. By synthesizing advances in multimodal perception, mechanistic simulation, and safe reinforcement learning, CIOS charts a roadmap toward dynamic, personalized oncology ...
Junye Zhu, Mengqi Yang, Chenxi Ouyang, Lin Zhang   +3 more
wiley   +1 more source

The role of inflammation in the immune evasion of KRas. [PDF]

Front Immunol
Homan EJ, Bremel RD.
europepmc   +1 more source

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

Neural cues differentially modulate colorectal cancer cell behavior depending on patients' genomic background. [PDF]

iScience
Thijssen MS, Chilà R, Crisafulli G, Smits KM, Bardelli A, Boesmans W, Melotte V.   +6 more
europepmc   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Ultra-sensitive detection of mutant <i>KRAS</i> in circulating tumor DNA predicts survival in resectable pancreatic adenocarcinoma. [PDF]

Front Oncol
Cox M, Wells A, Vitello D, Masnyk L, Janczewski LM, Rengaraju V, Peng C, Abad J, Zhang Q, Jia S, Du P, Chawla A.   +11 more
europepmc   +1 more source