Results 141 to 150 of about 151,900 (300)

Adagrasib in the Treatment of KRAS p.G12C Positive Advanced NSCLC: Design, Development and Place in Therapy [PDF]

Brian Warnecke,1 Misako Nagasaka1,2 1Department of Medicine, University of California Irvine School of Medicine, Chao Family Comprehensive Cancer Center, Orange, CA, USA; 2Department of Medicine, St.
Nagasaka M, Warnecke B
core  

The impact of KRAS mutations on the tumour microenvironment and treatment response in non-small cell lung cancer

Mutations in the KRAS gene in non-small cell lung cancer (NSCLC) are common drivers. Gene expression and mutation data of NSCLC were collected from the TCGA dataset.
Chunling Liu, Yan Zhao, Xiaodan Zhu, Yan Yang, Guomin Gu, Gang Sun   +5 more
core   +1 more source

A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin

Chemistry – A European Journal, EarlyView.
The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You, Monica Ching Suen, Haitao Miao, Yanyan Geng, Rahman Ud Din, Mu Yuan, Qiang Xue, Xiaoting Li, Naining Xu, Zhihong Guo, Hon‐Ming Lam, Kwok‐Wai Lo, Changdong Liu, Guang Zhu   +13 more
wiley   +1 more source

KRAS Gene Mutation Associated with Grade of Tumor Budding and Peripheral Immunoinflammatory Indices in Patients with Colorectal Cancer [PDF]

Liu Liang,1 Xuemin Guo,1 Wei Ye,1 Yuxiang Liu2 1Department of Laboratory Medicine, Meizhou People’s Hospital, Meizhou, People’s Republic of China; 2Department of Medical Oncology, Meizhou People’s Hospital, Meizhou, People’s Republic of ...
Liu Y, Guo X, Liang L, Ye W
core  

Synthesis of Chiral‐at‐Sulfur(VI) Sulfonimidamide Brønsted Acids

Chemistry – A European Journal, EarlyView.
A simple, modular route to chiral‐at‐sulfur(VI) Brønsted acids is described, delivering S‐chiral sulfonimidamides, C2‐symmetric acids, and BINOL‐based hybrid systems through stereospecific reactions of sulfonimidoyl fluorides and chlorides. ABSTRACT Herein, we report an efficient and simple strategy to access diverse chiral‐at‐sulfur(VI) Brønsted acids.
Yu Han, Natassa Lional, Dieuwertje E. Streefkerk, Jesse M. S. Goed, Bo Chen, Han Zuilhof, Fedor M. Miloserdov   +6 more
wiley   +1 more source

Undifferentiated carcinomas in a large animal model of liver cancer

Animal Models and Experimental Medicine, EarlyView.
F. Edward Boas, Olca Basturk, Zhirong Yin, Hooman Yarmohammadi, Lobna Elkhadragy, Jason Chiang, Imran Shair Mohammad, Stephen B. Solomon   +7 more
wiley   +1 more source

Trends and Future Directions in Organic Chemistry for Drug Discovery

Chemistry – A European Journal, EarlyView.
Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley   +1 more source

Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, EarlyView.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source

Long‐Term Prognosis, Residual Recurrence Risk, and Postoperative Management After Pathological Complete Response in Rectal Cancer

Cancer Nexus, EarlyView.
This graphical abstract summarizes the post‐pCR clinical pathway in locally advanced rectal cancer. After neoadjuvant radiotherapy and systemic therapy followed by surgery, patients achieving pCR (ypT0N0) generally have durable disease control, although residual risks of local and distant recurrence remain. Risk assessment, guideline‐based surveillance,
Jia‐ang Wang, Yingjiang Ye, Zhidong Gao, Sen Hou   +3 more
wiley   +1 more source

Contemporary Pastoral Activities For the Sake of Humanity, And Peace. Report of the Chaplain of the President of the Republic of Poland

The Person and the Challenges
Zbigniew Kras
doaj   +1 more source