Results 231 to 240 of about 260,030 (390)

Impact of <i>SERPINA3</i> on the Prognostic Role of KRAS G12R-Mutated Pancreatic Ductal Adenocarcinoma Patients Receiving Gemcitabine-Based Treatment: A Cross-Sectional Study. [PDF]

Health Sci Rep
He X, Ren L, Dong S, Liu W.
europepmc   +1 more source

KRAS Mutations As an Independent Prognostic Factor in Patients With Advanced Colorectal Cancer Treated With Cetuximab [PDF]

, 2008
Astrid Lièvre, Jean‐Baptiste Bachet, Valérie Boige, Anne Cayre, Delphine Le Corre, Emmanuel Buc, Marc Ychou, Olivier Bouché, Bruno Landi, Christophe Louvet, Thierry André, Frédéric Bibeau, Marie-Danièle Diébold, Philippe Rougier, Michel Ducreux, Gorana Tomasic, Jean-François Émile, Frédérique Penault–Llorca, Pierre Laurent–Puig   +18 more
openalex   +1 more source

Advances in biomarkers of resistance to KRAS mutation-targeted inhibitors. [PDF]

Discov Oncol
Wang L, Wei D, Li S, Jiang S.
europepmc   +1 more source

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice [PDF]

, 2008
Nils Habbe, Guanglu Shi, Robert A. Meguid, Volker Fendrich, Farzad Esni, Huiping Chen, Georg Feldmann, Doris A. Stoffers, Stephen F. Konieczny, Steven D. Leach, Anirban Maitra   +10 more
openalex   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

Thiazole peptidomimetics as chemical modulators of <i>KRAS</i> gene expression <i>via</i> G-quadruplex stabilization. [PDF]

RSC Chem Biol
Biswas D, Gorai A, Maiti S, Chaudhuri R, Pradhan S, Dash J.   +5 more
europepmc   +1 more source

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia [PDF]

, 2008
Jean-Paul De La O, Lyska L. Emerson, Jessica L. Goodman, Scott C. Froebe, Benjamin E. Illum, Andrew Curtis, L. Charles Murtaugh   +6 more
openalex   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

RAS Pathway Inhibitors Combined with Targeted Agents Are Active in Patient-Derived Spheroids with Oncogenic KRAS Variants from Multiple Cancer Types. [PDF]

Cancer Res Commun
Davoudi Z, Dexheimer TS, Coussens NP, Silvers T, Fox RG, Kemp SB, Juneja P, Morris J, Hollingshead MG, Takebe N, Doroshow JH, Teicher BA.   +11 more
europepmc   +1 more source

DEVELOPMENT OF METAPLASTIC PRECURSOR LESIONS IN MURINE PANCREAS FOLLOWING MUTANT KRAS EXPRESSION IN ADULT PDX1-POSITIVE CELLS

, 2007
Ulysses Burley, Adrian Charles, Morgan R. Barron, Carolyn Pelham, Thomas E. Adrian, R. Bell, Raymond J. MacDonald, Guang–Yu Yang, Paul J. Grippo   +8 more
openalex   +1 more source