Results 221 to 230 of about 151,900 (300)

Unexpected Long-Term Survival in Resected Pancreatic Ductal Adenocarcinoma Harboring KRAS G12R with an Ultra-Low-VAF SMAD4 Mutation: A Case Report and Mini-Review. [PDF]

Reports (MDPI)
Varzaru B, Croitoru AE, Iacob RA, Dima SO, Gheorghe C.   +4 more
europepmc   +1 more source

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

The Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot, Cibele Masotti, Claudia Corrò, Cédric Schraepen, Hannah L Williams, Thomas A Wright, Fiza Ishaqwala, Colin W Steele, Gertjan Rasschaert, Maxime W Lafarge, Enric Domingo, Inti Zlobec, Rodrigo Oliva Perez, Campbell SD Roxburgh, Timothy S Maughan, Sabine Tejpar, Thibaud Koessler, Viktor H Koelzer   +17 more
wiley   +1 more source

FOXD3 Is Functionally Linked to NF-κB Signaling in KRAS G12C-Mutant NSCLC Cells. [PDF]

Cells
Xu P, Peng J, Guo C, Liu Z, Cao Y, Sheng Q, Xu W, Li X.   +7 more
europepmc   +1 more source

Bortezomib‐based chemotherapy in Chinese pediatric patients with relapsed/refractory acute lymphoblastic leukemia: A single‐center retrospective study

Pediatric Investigation, EarlyView.
Bortezomib‐based chemotherapy achieved an 88.9% remission rate in Chinese pediatric patients with relapsed/refractory B‐cell acute lymphoblastic leukemia, enabling 62.5% of responders to bridge to transplantation, while T‐cell acute lymphoblastic leukemia showed no response.
Xingyu Zhao, Jian Wang, Liping Que, Dunhua Zhou, Jianpei Fang, Luhong Xu   +5 more
wiley   +1 more source

RAS–PI3Kα signaling regulates KrasG12D-induced lymphangiogenesis in complex lymphatic anomalies

Disease Models & Mechanisms
Lorenzo M. Fernandes, Jeffrey Tresemer, Angelica Vallejo, Alice Yao, Joshua P. Scallan, Michael T. Dellinger   +5 more
doaj   +1 more source

KRAS-driven cytokine-metabolic crosstalk shapes immune exclusion in pancreatic ductal adenocarcinoma. [PDF]

Front Genet
Huang C, Mai G, Li Y, Liu H, Huang W.
europepmc   +1 more source

Precision medicine in cancer: A comprehensive review of advanced cancer diagnosis technologies and personalized treatment strategies

Precision Medical Sciences, EarlyView.
The translational pipeline of precision medicine in clinical oncology. Schematic overview of the individualized cancer care workflow. (1) Input: Patient samples undergo multi‐omic profiling via NGS, single‐cell diagnostics, spatial maps, and epigenetic sequencing.
Asif Jan, Bushra Waheed, Rani Akbar, Daniel Dubwa   +3 more
wiley   +1 more source

Information‐Theoretic Framework for Allosteric Communication Pathway Prediction From Protein Structure

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Allosteric communication is fundamental to the function of proteins, but identifying the residue‐level pathways through which signals travel and their directionality is still a major challenge. Here we present a multi‐metric information‐theoretic framework that identifies candidate allosteric communication pathways from a single protein ...
Aysima Hacisuleyman, Dirk Fasshauer
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Integrated NGS and ddPCR analysis of RAS/RAF mutations in metastatic colorectal cancer among Kazakhstani patients: a pilot study. [PDF]

Front Med (Lausanne)
Kulmambetova G, Tarlykov P, Auganova D, Gusmaulemova A, Kurentay B, Mamlin M.   +5 more
europepmc   +1 more source