Results 221 to 230 of about 208,301 (303)

Detection of mutated KRAS, TP53, CDKN2A, and SMAD4 in tumor cell-free DNA of Brazilian pancreatic adenocarcinoma patients using next-generation sequencing. [PDF]

Sci Rep
Marin AM, Timoner BE, Araújo DD, Uno M, Alves MJF, Chammas R, Namur GN, Wosniaki DK, Canzian F, Blanes L, Zanette DL, Aoki MN.   +11 more
europepmc   +1 more source

Basal Cell Carcinoma and Syringocystoadenoma Papilliferum Arising in Naevus Sebaceous—A Narrative Review

ANZ Journal of Surgery, EarlyView.
ABSTRACT Naevus sebaceous (NS) is a congenital cutaneous hamartoma characterised by epidermal, follicular, sebaceous and apocrine components, with a rare but significant potential for malignant transformation, most commonly into basal cell carcinoma (BCC).
Yajat Dua, Chris Miller, Anand Ramakrishnan   +2 more
wiley   +1 more source

Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C. [PDF]

J Med Chem
Endres NF, Do S, Mroue R, Terrett JA, Saabye M, Oh A, Hunsaker T, Chan E, Tran JC, Nguyen LK, Lian Q, Ma TP, Garner T, Gerosa L, Beresini M, Boudreau A, Bronner SM, Cyr P, Ishisoko N, Izrayelit Y, Jiang F, Kellar T, La H, Labadie S, Lardy M, Liu L, Liu W, Miller S, Rudolph J, Plise E, Sellers BD, Shao C, Wang W, Wang Y, Wei W, Wong S, Yu C, Yu K, Yuen PW, Zang R, Zhang C, Zhou Y, Zhu X, Quinn JG, Ye X, Kiefer JR, Mao J, Evangelista M, Merchant M, Landry ML, Malhotra S, Purkey HE.   +51 more
europepmc   +1 more source

What Is the Evidence Base Regarding Early Onset Colorectal Cancer in Australia and New Zealand? A Scoping Review

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Early onset colorectal cancer (EoCRC), commonly defined as colorectal cancer diagnosed in people under 50 years of age, is increasing in incidence in Australia and New Zealand. The underlying cause of this remains unclear, despite its growing public health importance.
Tiffany J. Cherry, Dilshan Udayasiri, Ian P. Hayes   +2 more
wiley   +1 more source

Eosinophilic Biliary Cystic Neoplasm of the Liver: A Case Report of an Unrecognized Subtype of Intrahepatic Biliary Neoplasm. [PDF]

Pathol Int
Tanaka M, Koinuma D, Hinata M, Takeshita K, Yasunaga Y, Sakuma K, Takamoto T, Nishioka Y, Hasegawa K, Nakai Y, Ushiku T.   +10 more
europepmc   +1 more source

Circulating tumour cells (CTCs) in haematological malignancies: Advances in biology and clinical relevance with a focus on multiple myeloma

British Journal of Haematology, EarlyView.
Spatial heterogeneity limits the sensitivity of bone marrow biopsies, resulting in false‐negative findings. Circulating tumour cells (CTCs) provide a systemic, stratified monitoring approach, using flow cytometry for high tumour burden and EuroFlow or allele‐specific oligonucleotide PCR (ASO‐PCR) for minimal residual disease to enable early relapse ...
Chin‐Mu Hsu, Jui‐Feng Hsu, Jee‐Fu Huang, Yi‐Chang Liu   +3 more
wiley   +1 more source

Pan-KRAS inhibition: unlocking broad-spectrum targeted therapy for <i>KRAS</i>-mutant cancers. [PDF]

Cancer Biol Med
Feng J, Xiao X, Lian Z, Zhang A, Pang X.
europepmc   +1 more source

Real‐world treatment patterns and outcomes in accelerated and blast‐phase myeloproliferative neoplasms: Insights from a large multi‐centre cohort analysis in the United Kingdom

British Journal of Haematology, EarlyView.
Summary This UK‐based retrospective analysis describes real‐world treatment patterns and outcomes in 175 patients with accelerated (AP, n = 69) or blast‐phase (BP, n = 106) ‘Philadelphia‐negative’ myeloproliferative neoplasms (MPN‐AP/BP) diagnosed between 2013 and 2025. Median age at transformation was 71 years.
Alexandros Rampotas, Gabriel Naylor‐Layland, Clare Brown, Ahmad Alabdulkarim, Jennifer Ryan, Frances Wadelin, Samah Alimam, Phyo Wint Wint Tun, Jonathan Lambert, Jennifer O'Sullivan, Andrew J. Wilson, Laith Tafesh, Andrew McGregor, Simone Claudiani, Andrew Innes, Emily Booth, James Leveson, Steve Knapper, Mamta Garg, Mani Dubey, Theodora Vatopoulou, Charlotte Brierley, Wai Ka Natalie Leung, Graham Greenfield, Mary Frances McMullin, Alesia Khan, Kate Milne, Duncan Brian, Anna Godfrey, Claire N. Harrison, Bethan Psaila, Patrick Harrington, Amy Kirkwood, Tim C. P. Somervaille, Donal P. McLornan, on behalf of the UK Blood Cancer Research Network MPN Clinical Study Group   +35 more
wiley   +1 more source

Prognostic Implications of Codon-Specific <i>KRAS</i> Mutations in Localized and Advanced Stages of Pancreatic Cancer. [PDF]

JCO Precis Oncol
Raji S, Zaribafzadeh H, Jones T, Kanu E, Tong K, Fletcher A, Howell TC, McCall SJ, Marks JR, Rogers B, Niedzwiecki D, Allen PJ, Nussbaum DP, Kabiri Z.   +13 more
europepmc   +1 more source