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Nature Medicine
RAS family variants-most of which involve KRAS-are the most commonly occurring hotspot mutations in human cancers and are associated with a poor prognosis. For almost four decades, KRAS has been considered undruggable, in part due to its structure, which lacks small-molecule binding sites.
Anupriya Singhal +2 more
openaire +2 more sources
RAS family variants-most of which involve KRAS-are the most commonly occurring hotspot mutations in human cancers and are associated with a poor prognosis. For almost four decades, KRAS has been considered undruggable, in part due to its structure, which lacks small-molecule binding sites.
Anupriya Singhal +2 more
openaire +2 more sources
KRAS-Driven Tumorigenesis and KRAS-Driven Therapy in Pancreatic Adenocarcinoma
Molecular Cancer TherapeuticsAbstract Pancreatic ductal adenocarcinoma (PDAC) is associated with significant morbidity and mortality and is projected to be the second leading cause of cancer-related deaths by 2030. Mutations in KRAS are found in the vast majority of PDAC cases and plays an important role in the development of the disease.
Minh T. Than +3 more
openaire +2 more sources
1975
From the solid body of Asia a narrow peninsula runs south, ending in the island of Singapore and separating the Andaman Sea from the Gulf of Thailand and the South China Sea. In its northern end Burma and Thailand share the peninsula, Thailand at the eastern side.
openaire +1 more source
From the solid body of Asia a narrow peninsula runs south, ending in the island of Singapore and separating the Andaman Sea from the Gulf of Thailand and the South China Sea. In its northern end Burma and Thailand share the peninsula, Thailand at the eastern side.
openaire +1 more source
Targeting the MAPK Pathway in KRAS-Driven Tumors
Cancer Cell, 2020Matthias Drosten, Mariano Barbacid
exaly
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
Cell, 2018Chiara Ambrogio +2 more
exaly