Results 231 to 240 of about 151,900 (300)

Dinarski kras: Plitvi kras Zgornje Pivke

, 2018
openaire   +1 more source

Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights

Smart Molecules, EarlyView.
Molecular glues exert diverse core biological functions by inducing or stabilizing protein–protein interactions, extending far beyond the traditional scope of targeted protein degradation. Key breakthroughs include expanded cereblon substrate recognition, sustained G protein‐coupled receptor megacomplex signaling, and the first orthosteric molecular ...
Qingyun Guan, Xiaoyu Shi, Qian Yang, Xiangyi Jiang, Xinyong Liu, Peng Zhan   +5 more
wiley   +1 more source

Engineering metal‐organic framework‐based smart porous nanoplatforms for targeted therapy and theranostic applications

Smart Molecules, EarlyView.
MOFs offer high porosity and tunability for biomedical applications, especially in cancer therapy via ROS generation and targeted delivery. Though toxicity, stability, and scalability remain key clinical challenges. Drug loading in MOFs exceeds 60%–70% with controlled release behavior.
Jagabandhu Bag, Subhasis Banerjee, Sabyasachi Banerjee, Sourav De, S. K. Ashok Kumar, Yan‐Jye Shyong, Subhankar Mukhopadhyay   +6 more
wiley   +1 more source

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer. [PDF]

Cancer Rep (Hoboken)
Manav N, Kashyap A, Malhotra L, Rajegowda C, Prasad CP.   +4 more
europepmc   +1 more source

PFOA Exposure Elicits Quantitative Lipidomic Changes in the Pancreas in a Mouse Model of Pancreatic Cancer

Environmental Toxicology, EarlyView.
ABSTRACT Pancreatic cancer is the fourth leading cause of cancer deaths in the US and predicted to rise to second by 2030. Several risk factors have been identified as potential contributors to pancreatic cancer development including lifestyle factors and long‐term exposure to occupational and environmental carcinogens.
Barbara A. Hocevar, Lisa M. Kamendulis
wiley   +1 more source

Antitumor Activity of a Synthetic Small RNA Based on a <i>Maytenus hookeri</i> Sequence in Non-Small Cell Lung Cancer. [PDF]

Int J Mol Sci
Liu D, Yang X, Du S, Sun N, Lin Y, Dong Y, Jiang C.   +6 more
europepmc   +1 more source

Angiogenesis‐associated immune genes as prognostic markers and predictors of immunotherapy response in pancreatic ductal adenocarcinoma

VIEW, EarlyView.
Pancreatic ductal adenocarcinoma exhibits marked angiogenic and immune heterogeneity. We identified 28 angiogenesis‐associated immune genes and developed a seven‐gene AIGScore model comprising FGF2, ADGRB3, MMP2, TYMP, VASH1, VEGFD, and ITGAV. A high AIGScore was associated with poor survival, an immunosuppressive tumor microenvironment, and reduced ...
Qing Chang, Qian Wang, Xiumei Jiang, Yongmei Yang, Ailin Qu   +4 more
wiley   +1 more source

Anticancer effects of an XPO1 inhibitor (selinexor) with sotorasib following omeprazole preconditioning in KRAS G12C-mutant non-small cell lung cancer cells in vitro and in a mouse tumor xenograft. [PDF]

Neoplasia
González J, Cai X, Diao W, Roué G, València-Clua K, Olmo-González D, González-Cao M, Jain A, Jantus-Lewintre E, Giménez-Capitán A, Molina-Vila MA, Codony-Servat J, Cao P, Rosell R.   +13 more
europepmc   +1 more source

The Earliest Feathers from the Lower Cretaceous Dabeigou Formation of North Hebei: Implications for the Early Evolution of the Jehol Biota

Integrative Zoology, EarlyView.
This study reports two isolated feather fossils from the Lower Cretaceous Dabeigou Formation in northeastern China. Morphological analyses identified them as the earliest known feathered theropods (potentially including avian) in the Jehol Biota. This finding reveals a complex ecosystem at the dawn of the Jehol Biota, bridging the temporal and faunal ...
Qian Wu, Qian‐Nan Zhang, Dang‐Peng Xi   +2 more
wiley   +1 more source

Discovery of Highly Efficacious CRBN-Based KRAS Degraders Targeting Cancers with KRAS G12D and G12V Mutations. [PDF]

J Med Chem
Wang C, Ghosh P, Jin S, Bai L, Aguilar A, McEachern D, Wang M, Li Q, Wen B, Sun D, Wang S.   +10 more
europepmc   +1 more source